Determinant factors of recurrence atopic dermatitis symptoms in children: A cross-sectional study

Al-Adawiyah, Robiah; Putera, Azwin Mengindra; Astari, Linda; Ariyanto, Fis Citra

doi:10.1016/j.amsu.2021.102847

Cited by 8 publications

(5 citation statements)

References 30 publications

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“…The most substantial correlation with food allergies was observed in cases where there was a previous history of suspected food allergies. This aligns with the findings of previous studies (Yang et al 2020, Al-Adawiyah et al 2021. The findings imply that if children exhibit persistent respiratory or atopic dermatitis symptoms and have a previous history of suspected food allergies, it is advisable to consider the possibility that food allergies may be the underlying cause of these symptoms.…”

Section: Discussionsupporting

confidence: 89%

Preliminary Investigation of Risk Factors for Food Allergies in the Pediatric Population: Observations from a Survey Utilizing a Simplified Questionnaire in Gresik, East Java, Indonesia

Natalia Erica Jahja,

Zahrah Hikmah,

Azwin Mengindra Putera

et al. 2024

FMI

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Highlights:1. A questionnaire, comprising various risk factors associated with food allergies, is anticipated to provide reliable indications for determining the necessity of restrictive diets for patients within primary healthcare settings.2. Over time, the findings of this study can facilitate the development of a streamlined and cost-effective diagnostic tool, which will be particularly beneficial in remote regions due to its practical and efficient means of identifying food allergies. AbstractIn Gresik, Indonesia, limited resources have led to challenges in accurately diagnosing food allergies. This study aimed to identify risk factors for food allergies among children in Gresik using a questionnaire-based approach. The study’s ultimate goal was to develop a simple diagnostic tool in primary healthcare settings. Conducted at Petrokimia Gresik Hospital, this cross-sectional study enrolled children aged ≥6 months experiencing respiratory symptoms or atopic dermatitis for ≥1 week. The subjects (n = 247) underwent a two- to four-week restrictive diet for diagnostic purposes. The questionnaire demonstrated validity and reliability. Bivariate statistical analyses were performed to examine the correlations between risk factors and the incidence of food allergies (p < 0.05). A receiver operating characteristic (ROC) curve analysis was used to establish the cut-off values for the number of food allergies and atopic family members. The majority of the 247 children enrolled in this study were 6 to 12 years old. Respiratory symptoms (56.3%) were more common than atopic dermatitis (38.1%). The significant risk factors for food allergies included atopic dermatitis (p = 0.001; R = 0.203), previous history of suspected food allergies (p < 0.001; R = 0.747), and atopy in the family (p = 0.013; R = 0.157). The ROC curve analysis established the cut-off values for the number of atopic family members at 1.5 (p = 0.005; 95% CI 0.53-0.67) and the number of food allergies at 0.5 (p = 0.000; 95% CI 0.85-0.94). In conclusion, children are considered at risk of food allergies if they display persistent respiratory symptoms or atopic dermatitis, considering the history of suspected food allergies even to only one specific type of food.

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Section: Discussionsupporting

confidence: 89%

Preliminary Investigation of Risk Factors for Food Allergies in the Pediatric Population: Observations from a Survey Utilizing a Simplified Questionnaire in Gresik, East Java, Indonesia

Natalia Erica Jahja,

Zahrah Hikmah,

Azwin Mengindra Putera

et al. 2024

FMI

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“…In addition, the activity of hormones in atopic dermatitis (AD) has been demonstrated [ 52 ], with a different dermatological manifestation based on IgE sensitization only in male patients [ 53 ].…”

Section: Sex Differences In Autoimmune Diseases Inflammatory Disorder...mentioning

confidence: 99%

Sex, Allergic Diseases and Omalizumab

et al. 2022

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Gender differences are increasingly emerging in every area of medicine including drug therapy; however, specific gender-targeted studies are infrequent. Sex is a fundamental variable, which cannot be neglected. When optimizing therapies, gender pharmacology must always be considered in order to improve the effectiveness and safety of the use of drugs. Knowledge of gender differences promotes appropriate use of therapies and greater health protection for both genders. Further development of gender research would make it possible to report on differences in the assimilation and response of the female organism as compared to the male, in order to identify potential risks and benefits that can be found between genders. Furthermore, a better understanding of sex/gender-related influences, with regard to pharmacological activity, would allow the development of personalized “tailor-made” medicines. Here, we summarize the state of knowledge on the role of sex in several allergic diseases and their treatment with omalizumab, the first biologic drug authorized for use in the field of allergology.

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“…Other patients experience a persistent trajectory, but evidence for relapses, persistence, or onset in adulthood is growing. 2,3 Important pathophysiologic hallmarks are a T helper 2 (Type-2) polarization of the immune system and increased total serum immunoglobulin E (IgE) levels in about 80% of cases with frequent sensitizations against seasonal or perennial allergens. 4,5 Further important mechanistic factors include disturbed skin barrier function, which can be elicited or aggravated by Type-2-immune dysregulation and microbiome alteration with widespread Staphylococcus aureus colonization.…”

Section: Introductionmentioning

confidence: 99%

“…It commonly starts in early childhood and affects up to 25% of children, 1 but many AD patients outgrow the disease before adolescence with a remaining prevalence of 2%–8% in adults. Other patients experience a persistent trajectory, but evidence for relapses, persistence, or onset in adulthood is growing 2,3 . Important pathophysiologic hallmarks are a T helper 2 (Type‐2) polarization of the immune system and increased total serum immunoglobulin E (IgE) levels in about 80% of cases with frequent sensitizations against seasonal or perennial allergens 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Immunoglobulin E autoantibodies in atopic dermatitis associate with Type‐2 comorbidities and the atopic march

Kortekaas Krohn,

Badloe,

Herrmann

et al. 2023

Allergy

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BackgroundAutoreactive immunoglobulin E (IgE) antibodies to self‐peptides within the epidermis have been identified in patients with atopic dermatitis (AD). Prevalence, concomitant diseases, patient characteristics, and risk factors of IgE autoantibody development remain elusive. We aimed to determine IgE autoantibodies in serum samples (n = 672) from well‐characterized patients with AD and controls (1.2–88.9 years).MethodsAtopic dermatitis patients were sub‐grouped in AD with comorbid Type‐2 diseases (“AD + Type 2”; asthma, allergic rhinitis, food allergy, n = 431) or “solely AD” (n = 115). Also, subjects without AD but with Type‐2 diseases (“atopic controls,” n = 52) and non‐atopic “healthy controls” (n = 74) were included. Total proteins from primary human keratinocytes were used for the immunoassay to detect IgE autoantibodies. Values were compared to already known positive and negative serum samples.ResultsImmunoglobulin E autoantibodies were found in 15.0% (82/546) of all analyzed AD‐patients. “AD + Type 2” showed a higher prevalence (16.4%) than “solely AD” (9.6%). “Atopic controls” (9.6%) were comparable with “solely AD” patients, while 2.7% of healthy controls showed IgE autoantibodies. Of those with high levels of IgE autoantibodies, 15 out of 16 were patients with “AD + Type 2”. AD patients with IgE autoantibodies were younger than those without. Patients with IgE autoreactivity also displayed higher total serum IgE levels. Factors that affected IgE autoantibody development were as follows: birth between January and June, cesarean‐section and diversity of domestic pets.ConclusionsImmunoglobulin E autoantibodies in AD seem to associate with the presence of atopic comorbidities and environmental factors. The potential value of IgE autoantibodies as a predictive biomarker for the course of AD, including the atopic march, needs further exploration.

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Determinant factors of recurrence atopic dermatitis symptoms in children: A cross-sectional study

Cited by 8 publications

References 30 publications

Preliminary Investigation of Risk Factors for Food Allergies in the Pediatric Population: Observations from a Survey Utilizing a Simplified Questionnaire in Gresik, East Java, Indonesia

Preliminary Investigation of Risk Factors for Food Allergies in the Pediatric Population: Observations from a Survey Utilizing a Simplified Questionnaire in Gresik, East Java, Indonesia

Sex, Allergic Diseases and Omalizumab

Immunoglobulin E autoantibodies in atopic dermatitis associate with Type‐2 comorbidities and the atopic march

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