Determinação dos valores hematológicos e das concentrações séricas de ferro e ferritina em sangue de cordão umbilical de recém-nascidos de termo e pré-termo no Hospital Israelita Albert Einstein de São Paulo

Abstract

Determinaram-se os valores hematológicos (Hb, Ht, VCM, HCM, CHCM, reticulócitos) e as concentrações séricas de ferro e ferritina no sangue de cordão umbilical de recém-nascidos (RN) no Hospital Albert Einstein. A amostra continha 32 RN de termo (T) e 30 RN pré-termo (PT). Os RN apresentavam-se clinicamente sadios, sendo excluídos os que apresentaram intercorrências clínicas ou no momento do parto. O sangue foi colhido por punção da veia umbilical até 5 minutos após a dequitação e encaminhado ao laboratório de patologia clínica para processamento laboratorial. Os valores hematológicos encontram-se mais elevados no grupo de RNT em relação ao grupo de RNPT (p<0,05). Ajustando-se um modelo de regressão logística múltipla, o Ht tem valor preditivo para a prematuridade, observando-se uma relação inversamente proporcional entre o valor do Ht e a idade gestacional.

Erythrocyte indices and serum ferritin in newborns

“…Some of them classified newborns according to their weight-for-gestationalage-categories (3,5,9) while others did not. (6)(7)(8)10) Our results regarding RBC parameters were similar to those reported in some studies (3,8,10) and lower than those observed in others. (5,6,9) We also observed that our results were lower than those usually used as reference standards in neonatology.…”

“…Preterm AGA newborns, however, exhibited the lowest mean values of serum ferritin, similar to what was previously reported, (6) and this is mainly related to their low iron deposit. (24) Our study also evaluated RDW.…”

“…(14) Our findings of low mean values for Hb, RBC, Hct, and high mean values for MCV observed in preterm AGA newborns, are similar with those reported by other authors. (3,6) These characteristics of preterm newborns are related to physiologic immaturity of the erythropoietic system. (23,24) We evaluated serum ferritin levels at birth as an indicator of iron deposits in newborns.…”

“…(2)(3)(4)(5) Furthermore, studies have reported lower values for preterm AGA newborns. (3,6) Reference hematological values for cord blood have not been standardized, and routinely out of date values proposed in the literature are used. (7) In published studies, information on hematological values in cord blood is limited and inconsistent.…”

“…(7) In published studies, information on hematological values in cord blood is limited and inconsistent. The studies that we found (3)(4)(5)(6)(8)(9)(10) evaluated different subgroups of neonates and different hematological parameters. In particular, little data regarding hematological parameters of SGA newborns was found.…”