Deterioration of the circadian variation of heart rate variability in Brugada syndrome may contribute to the pathogenesis of ventricular fibrillation

Tokuyama, Takehito; Nakano, Yukiko; Awazu, Akinori; Uchimura-Makita, Yuko; Fujiwra, Mai; Watanabe, Yoshikazu; Sairaku, Akinori; Kajihara, Kenta; Motoda, Chikaaki; Oda, Noboru; Kihara, Yasuki

doi:10.1016/j.jjcc.2013.12.001

Cited by 13 publications

(22 citation statements)

References 33 publications

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“…Furthermore, the results confirm previous findings where symptomatic BS patients showed higher vagal [4,5,7] and reduced sympathetic [7] tones with respect to asymptomatic patients, supporting the idea that decreased sympathetic and increased vagal responses could be related to a worse prognosis in BS.…”

Section: Resultssupporting

confidence: 89%

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Time-frequency Analysis of the Autonomic Response to Head-up Tilt Testing in Brugada Syndrome

Calvo¹,

Rolle²,

Romero³

et al. 2017

Computing in Cardiology Conference (CinC)

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Cardiac events in Brugada syndrome (BS) usually occur at rest and mainly at nighttime, commonly relating changes in autonomic modulation to arrhythmogenesis. A major challenge today is to differentiate symptomatic and asymptomatic patients in order to optimize their therapy. Since autonomic assessment can be improved by the application of standard maneuveurs, this study analyzes and compares the autonomic response to head-up tilt (HUT) testing on 20 symptomatic and 45 asymptomatic BS patients. Their standard 12-lead ECG recordings were collected during a HUT test composed of the following three phases: (1) supine rest for 10 minutes, (2) tilting with an inclination of 60• for 45 minutes and (3) supine rest for 10 minutes. Spectral non-stationary heart rate variability indicators were extracted by means of a Smoothed Pseudo Wigner Ville distribution approach that adapts frequency bands to respiratory information. Symptomatic patients showed an increased parasympathetic tone and a reduced sympathovagal balance with respect to asymptomatic patients during tilting, and particularly before the 15 th minute of the test. The results provide new insights into the autonomic function in BS, with a potential impact on the use of timereduced HUT testing for risk stratification.

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Section: Resultssupporting

confidence: 89%

“…Thus, changes in the autonomic modulation captured by heart rate variability (HRV) analysis may provide valuable information for risk stratification. Indeed, previous studies have already analyzed the autonomic function in BS, but they are mostly based on longterm measurements leading to contradictory results [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Time-frequency Analysis of the Autonomic Response to Head-up Tilt Testing in Brugada Syndrome

Calvo¹,

Rolle²,

Romero³

et al. 2017

Computing in Cardiology Conference (CinC)

View full text Add to dashboard Cite

show abstract

“…They concluded that established single risk factors, such as family history of sudden death and EPS, displayed low specificities and low positive predictive values [18]. Several reports have noted the prognostic value of non-invasive ECG findings, such as firstdegree atrioventricular block [5], late potential [19], and heart rate variability [20]. In this study, we focused on another non-invasive examination and analyzed blood biomarkers.…”

Section: Discussionmentioning

confidence: 97%

Circulating heart-type fatty acid-binding protein levels predict ventricular fibrillation in Brugada syndrome

Daidoji

Arimoto

Iwayama

et al. 2016

Journal of Cardiology

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“…Indeed, previous works, focused on the analysis of the autonomic nervous system (ANS) function using positron emission tomography, have identified sympathetic dysfunctions on BS patients (Kies et al 2004, Wichter, et al 2002, Bigi, et al 2008, Paul, et al 2011. Also, many previous works have studied the autonomic function of BS patients through HRV analysis (Krittayaphong, et al 2003, Hermida, et al 2003, Kostopoulou, et al 2010, Nakazawa, et al 2003, Makimoto, et al 2010, Tokuyama, et al 2014, Pierre, et al 2007). However, these works are based on linear, time and frequency-domain methods, being unable to capture the complex, non-linear effects on heart rate (HR) regulation.…”

Section: Introductionmentioning

confidence: 99%

Heart rate complexity analysis in Brugada syndrome during physical stress testing

et al. 2017

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Abstract. Symptoms such as ventricular arrhythmias in Brugada syndrome (BS) typically occur at rest, especially during sleep, suggesting that the autonomic nervous system (ANS) function may be relevant in the arrhythmogenesis of the disease. The aim of this work was to assess the ANS response captured by a non-linear heart rate variability (HRV) measure in 69 patients diagnosed with BS, who underwent a standardized physical stress test. Heart rate complexity (HRC) was evaluated by the power-law scaling analysis (β slope) during rest, exercise, recovery and rest post-recovery, in order to discriminate between symptomatic and asymptomatic BS patients. Symptomatic patients showed a significant reduction in HRC in comparison to asymptomatic subjects, after exertion (p=0.015); during the whole recovery period (p=0.023), and, in particular within the passive recovery phase (p=0.025), as well as during rest post-recovery (p=0.022). Based on these results, symptoms could be associated with a lower ANS complexity during the stress test stages where parasympathetic activity is predominant. Therefore, the proposed HRV indicators could be of help in the risk stratification of asymptomatic patients.

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Deterioration of the circadian variation of heart rate variability in Brugada syndrome may contribute to the pathogenesis of ventricular fibrillation

Abstract: Lack of the circadian variation of autonomic function occurs in Brs, and this may contribute to the pathogenesis of VF.

Cited by 13 publications

References 33 publications

Time-frequency Analysis of the Autonomic Response to Head-up Tilt Testing in Brugada Syndrome

Time-frequency Analysis of the Autonomic Response to Head-up Tilt Testing in Brugada Syndrome

Circulating heart-type fatty acid-binding protein levels predict ventricular fibrillation in Brugada syndrome

Heart rate complexity analysis in Brugada syndrome during physical stress testing

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