Circulating heart-type fatty acid-binding protein levels predict ventricular fibrillation in Brugada syndrome

Daidoji, Hyuma; Arimoto, Takanori; Iwayama, Tadateru; Ishigaki, Daisuke; Hashimoto, Naoaki; Kumagai, Yu; Nishiyama, Satoshi; Takahashi, Hiroki; Shishido, Tetsuro; Miyamoto, Takuya; Watanabe, Tetsu

doi:10.1016/j.jjcc.2015.04.011

Cited by 4 publications

(4 citation statements)

References 30 publications

(33 reference statements)

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“…Moreover, with increasing FABP3 levels, the patients had higher rates of hypertension, diabetes mellitus, abnormal QTc interval, LVSD, and all-cause mortality, and higher levels of hs-CRP, WBC count, and visfatin. These findings are consistent with current evidence that FABP3 can be considered to be a prognostic marker for arrhythmia, heart failure, AMI, and pulmonary embolism, all of which are associated with poor clinical outcomes [31,[32][33][34], and that inflammation induced by FABP3 may lead to CVD [15]. Previous studies have shown that AF and premature ventricular contractions can induce FABP3 leakage [35,36], and ventricular cell loss caused by apoptosis has been confirmed in AF tachycardiainduced cardiomyopathy [37,38].…”

Section: Discussionsupporting

confidence: 90%

“…Hence, AF-induced apoptosis and sympathetic nervous system activation may contribute to FABP3 leakage in patients with AF. Furthermore, FABP3 has been reported to be elevated in patients with Brugada syndrome and ventricular fibrillation despite the absence of structural heart disease and cardiac dysfunction [32]. Therefore, assessing FABP3 could provide useful information in patients with arrhythmia.…”

Section: Discussionmentioning

confidence: 99%

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Elevated plasma fatty acid-binding protein 3 is related to prolonged corrected QT interval and reduced ejection fraction in patients with stable angina

Lu¹,

Lee²,

Hsuan³

et al. 2021

Int. J. Med. Sci.

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Background: Higher concentrations of plasma fatty acid-binding protein 3 (FABP3) play a role in the development of cardiovascular events, cerebrovascular deaths, and acute heart failure. However, little is known about the relationship between plasma FABP3 level and prolonged QT interval and reduced ejection fraction (EF). This study aimed to investigate the relationship between plasma FABP3 level and prolonged corrected QT (QTc) interval and reduced EF in patients with stable angina. Inflammatory cytokine and adipocytokine levels were also measured to investigate their associations with plasma FABP3. Methods: We evaluated 249 consecutive patients with stable angina. Circulating levels of FABP3 were measured by ELISA. In addition, 12-lead ECG and echocardiography recordings were obtained from each patient. Results: Multiple regression analysis showed that high-density lipoprotein cholesterol, high sensitivity C-reactive protein (hs-CRP), white blood cell (WBC) count, visfatin, adiponectin, FABP4, heart rate, QTc interval, left atrial diameter, left ventricular mass index, end-systolic volume, end-systolic volume index, fractional shortening, and EF were independently associated with FABP3 (all p<0.05). Patients with an abnormal QTc interval had a higher median plasma FABP3 level than those with a borderline and normal QTc interval. With increasing FABP3 tertiles, the patients had higher frequencies of abnormal QTc interval, left ventricular systolic dysfunction, and all-cause mortality, incrementally lower EF, higher WBC count, and higher levels of hs-CRP, visfatin, adiponectin, and FABP4. Conclusion: This study indicates that plasma FABP3 may act as a surrogate parameter of prolonged QTc interval and reduced EF in patients with stable angina, partially through the effects of inflammation or cardiomyocyte injury. Further studies are required to elucidate whether plasma FABP3 plays a role in the pathogenesis of QTc prolongation and reduced EF.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Elevated plasma fatty acid-binding protein 3 is related to prolonged corrected QT interval and reduced ejection fraction in patients with stable angina

Lu¹,

Lee²,

Hsuan³

et al. 2021

Int. J. Med. Sci.

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show abstract

“…Of note, this genetic disorder is defined by inherited sodium channel dysfunction with consequent risk of SCD [122]. Also in this high risk population serum H-FABP levels (>2.4 ng/mL), but not Troponin T levels, were an independent prognostic factor for appropriate ICD shocks due to VF (during a five-year follow up) indicating H-FABP as a promising biomarker for the prediction of malignant ventricular arrhythmias [93].…”

Section: Heart-type Fatty Acid Binding Protein (H-fabp)mentioning

confidence: 79%

Classic and Novel Biomarkers as Potential Predictors of Ventricular Arrhythmias and Sudden Cardiac Death

Shomanova

Ohnewein

Schernthaner

et al. 2020

JCM

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Sudden cardiac death (SCD), most often induced by ventricular arrhythmias, is one of the main reasons for cardiovascular-related mortality. While coronary artery disease remains the leading cause of SCD, other pathologies like cardiomyopathies and, especially in the younger population, genetic disorders, are linked to arrhythmia-related mortality. Despite many efforts to enhance the efficiency of risk-stratification strategies, effective tools for risk assessment are still missing. Biomarkers have a major impact on clinical practice in various cardiac pathologies. While classic biomarkers like brain natriuretic peptide (BNP) and troponins are integrated into daily clinical practice, inflammatory biomarkers may also be helpful for risk assessment. Indeed, several trials investigated their application for the prediction of arrhythmic events indicating promising results. Furthermore, in recent years, active research efforts have brought forward an increasingly large number of “novel and alternative” candidate markers of various pathophysiological origins. Investigations of these promising biological compounds have revealed encouraging results when evaluating the prediction of arrhythmic events. To elucidate this issue, we review current literature dealing with this topic. We highlight the potential of “classic” but also “novel” biomarkers as promising tools for arrhythmia prediction, which in the future might be integrated into clinical practice.

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“…It is important to identify patients at a high risk of a sudden cardiac death in order to determine the strict indication of prophylactic ICD use in clinical practice. In several previous reports, the importance of cTnT evaluation as a marker for worse prognosis has been assessed in various types of patients [17] , [18] , [19] , [20] , [21] , [22] . Sato et al demonstrated that elevation of serum cTnT levels was associated with higher mortality and myocyte degeneration in patients with idiopathic dilated cardiomyopathy [17] .…”

Section: Discussionmentioning

confidence: 99%

Cardiac troponin T as a predictor of cardiac death in patients with left ventricular dysfunction

Nakamura

Niwano

Fukaya

et al. 2017

Journal of Arrhythmia

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BackgroundCardiac troponin T (cTnT) has been reported to be associated with cardiac mortality.In the present study, we evaluated the role of routine assessment of cTnT as a predictor of future cardiac death in patients with left ventricular (LV) dysfunction.MethodsPatients who were eligible for prophylactic implantable cardioverter defibrillator (ICD) were included from cardiac catheterization database. Inclusion criteria were patients with LV ejection fraction of ≤ 35% and with New York Heart Association (NYHA) ≥class II. Exclusion criteria were patients with acute coronary syndrome, ICD for secondary prevention, NYHA class IV, and lack of data. The final study patients were divided into the following three groups in accordance with two quartile points of serum cTnT levels: low cTnT, intermediate cTnT, and high cTnT groups. The primary endpoint of this study was cardiac death.ResultsA total of 70 patients were included (mean age, 62±13 years; male individuals, 56; ischemic, 36; and non-ischemic, 34). During the observation period of 2.2 years, cardiac death was observed in 17 patients (fatal arrhythmic event, 9; heart failure, 7; myocardial infarction, 1). In the Kaplan–Meier analysis, the high cTnT group showed the highest risk among all the groups (p<0.001). Even in sub-analyses for ischemic and non-ischemic patients, the results were the same, and the high cTnT group showed the highest event rate (p<0.05). In contrast, no cardiac death was observed in the low cTnT group.ConclusionThe cTnT levels in a stable state were associated with cardiac death in patients with LV dysfunction, even in those with non-ischemic diseases.

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Circulating heart-type fatty acid-binding protein levels predict ventricular fibrillation in Brugada syndrome

Abstract: Evaluating myocardial damage using H-FABP may be a promising tool for predicting ventricular arrhythmia in patients with Brugada syndrome who have received ICDs.

Cited by 4 publications

References 30 publications

Elevated plasma fatty acid-binding protein 3 is related to prolonged corrected QT interval and reduced ejection fraction in patients with stable angina

Elevated plasma fatty acid-binding protein 3 is related to prolonged corrected QT interval and reduced ejection fraction in patients with stable angina

Classic and Novel Biomarkers as Potential Predictors of Ventricular Arrhythmias and Sudden Cardiac Death

Cardiac troponin T as a predictor of cardiac death in patients with left ventricular dysfunction

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