Deterioration of Peritoneal Membrane Permeability in a Patient on Antituberculous Treatment

Grzegorzewska, A.; Baczyk, K; Szymaczek-Meyer, L

doi:10.1177/089686088600600312

Cited by 3 publications

(3 citation statements)

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“…Pyrazinamide's influence cannot be explained by alterations in blood flow, drain volume rate, lymphatic absorption, or some other known action of the drug on the membrane's integrity. Therefore, this fraction of our results — the diminished urate excretion — agrees with previous observations by Grzegorzewska and her team, extending them, however, with data on urea and creatinine kinetics (4,17).…”

Section: Discussionsupporting

confidence: 93%

“…Pyrazinamide and PB are well-known modulators of renal urate transport, but their influence on peritoneal urate transport in vivo has not been investigated. However, hyperuricemia was observed by Grzegorzewska et al in a patient on intermittent peritoneal dialysis (IPD) while he was being treated with PZA as part of an antituberculous regimen (17). Sub- In the present study, oral administration of PZA resulted in decreases of both peritoneal clearances and MTACs of urea, creatinine, and urate.…”

Section: Discussionsupporting

confidence: 41%

“…However, hyperuricemia was observed by Grzegorzewska et al . in a patient on intermittent peritoneal dialysis (IPD) while he was being treated with PZA as part of an antituberculous regimen (17). Subsequent in vitro studies in human and rabbit peritoneum confirmed a decrease in urate clearance after PZA administration (4).…”

Section: Discussionmentioning

confidence: 99%

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Effect of Pyrazinamide and Probenecid on Peritoneal Urate Transport Kinetics during Continuous Ambulatory Peritoneal Dialysis

Spaia¹,

Magoula

Tsapas

et al. 2000

Perit Dial Int

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Objective We administered pyrazinamide (PZA) and probenecid (PB) — two well-known modulators of urate transport via the proximal tubules — to evaluate their impact on urate transport through the peritoneal membrane and to clarify mechanisms affecting peritoneal transport. Setting A continuous ambulatory peritoneal dialysis (CAPD) unit in 2nd Hospital of IKA (Social Services Institute), Greece. Patients In 20 stable CAPD patients, on the study day, a 4-hour, 2-L, 1.36% glucose exchange was performed (control exchange). Pyrazinamide 3 g was given orally and another identical exchange was performed (study exchange). The same protocol was repeated with 2 g PB. Kt/V, peritoneal clearances of urea, creatinine, and urate for each exchange, and mass transfer area coefficients (MTAC) for the three solutes and their dialysate-to-plasma concentration (D/P) ratios were used to estimate peritoneal transport. Results Administration of PZA resulted in decreased clearances and MTAC values for the three solutes. The D/P ratio decreased significantly only for urate, indicating a more intense influence of PZA on urate. After PB administration, clearances of urea, creatinine, and urate were increased. MTAC and D/P ratio increased significantly only for urate ( p < 0.05), demonstrating an action similar to that exerted on renal tubules. Conclusions These findings provide evidence that unrestricted diffusion is not the only transport mechanism in the case of urate, and demonstrate the existence of an active mechanism in peritoneal urate transport with a reabsorptive and, probably, a secretive component that resembles that of renal tubule urate transport. Attention should be given in the case of CAPD patients undergoing antituberculous (PZA) treatment: it might have a negative impact on urea, creatinine, and urate peritoneal transport rates.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 41%

See 1 more Smart Citation

Effect of Pyrazinamide and Probenecid on Peritoneal Urate Transport Kinetics during Continuous Ambulatory Peritoneal Dialysis

Spaia¹,

Magoula

Tsapas

et al. 2000

Perit Dial Int

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Change in the Transport of Uric Acid under the Influence of Pyrazinoic Acid: In Vitro Studies with Human and Rabbit Peritoneum

Czyżewska¹,

Grzegorzewska

Knapowski³

1989

Perit Dial Int

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Bidirectional transport of uric acid (UA) through human and rabbit peritoneum, and its change under the influence of pyrazinoic acid (PA) was investigated in vitro. Fragments of parietal peritoneum were taken from the region of anterior abdominal wall from rabbits (the animal series) and from patients undergoing abdominal operations (the human series). Under control conditions, higher values of the UA transport were found in the rabbit peritoneum in comparison with the human peritoneum, but in both series it was maintained at a constant level throughout the experiment lasting 120 min. In rabbit as well as in human peritoneum it was found that PA depressed about 50% of the UA transport from the interstitial to the mesothelial side, leaving the opposite direction intact. The results obtained in vitro are in agreement with previous observations in a patient undergoing peritoneal dialysis that showed decreased peritoneal UA excretion evoked by pyrazinamide. The comparative analysis proves the rabbit peritoneum to be a good experimental model for further investigations of peritoneal urate transport in man.

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Case Forum

Vas¹,

Twardowski

Schreiber

et al. 1997

Perit Dial Int

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Deterioration of Peritoneal Membrane Permeability in a Patient on Antituberculous Treatment

Cited by 3 publications

References 1 publication

Effect of Pyrazinamide and Probenecid on Peritoneal Urate Transport Kinetics during Continuous Ambulatory Peritoneal Dialysis

Effect of Pyrazinamide and Probenecid on Peritoneal Urate Transport Kinetics during Continuous Ambulatory Peritoneal Dialysis

Change in the Transport of Uric Acid under the Influence of Pyrazinoic Acid: In Vitro Studies with Human and Rabbit Peritoneum

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