Deteksi Kadar Transforming Growth Factor (Tgf-Β) Pada Luka Akut

Wulandari, Pratidina; Hutagalung, Magda Rosalina; Perdanakusuma, David S

doi:10.20473/jre.v6i1.28225

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…In this study the concentration of TGF-β tended to decrease on H-14 compared to D-7. These results are different from the report of Wulandari et al [29], who reported that there was an increase in TGF-β on H-21 compared to H-5 in acutely injured rats. Oskeritzian [30], stated that an increase in TGF-β causes the activation of fibroblast proliferation which is necessary for collagen synthesis.…”

Section: Groupscontrasting

confidence: 99%

Wound Healing Activity of Transdermal Patches of Carica Papaya, Chromolaena Odorata, and Averrhoa Bilimbi Leaves on Incision Wounds of Hyperglycemic Rat

Santi,

Siregar,

Sutriana

et al. 2023

Trends Sci

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Transdermal patches have been used for drug delivery to accelerate the wound healing process with minimum negative effect. This study evaluated the wound healing potential of transdermal patches containing Carica papaya, Chromolaena odorata, and Averrhoa bilimbi leaves extract on hyperglycemic rat as a diabetic wound model. For this purpose, a total of 40 Wistar rats aged 2 - 3 months were randomly distributed into 10 groups. The first 5 groups (P1, P2, P3, P4 and P5) consisted of normal rats which received normal dressing, TP Dermafix, TP of C. papaya, TP of C. odorata, and TP of A. bilimbi, respectively. The second 5 groups (P6, P7, P8, P9 and P10) were hyperglycemic rats that received normal dressing, TP Dermafix, TP of C. papaya, TP of C. odorata, and TP of A. bilimbi, respectively. Skin incisions were made perpendicular to the spine in the thickest part of the skin with an incision length of 2 cm and a depth of 0.5 cm. Patches were applied to the incisions according to the test group and replaced every 2 days for a period of 13 days. Wound healing activity was determined by evaluating the Clinical Sign of Inflammation (CSI) score, wound closure, TGF-β1 concentration, and histology of skin tissue. Data were analyzed using oneway analysis of variance (ANOVA). The results showed that for each parameter observed, the rats intervened with transdermal patches loaded with extract leaves had higher healing potential and different from the control group (normal dressing without intervene) both in normal and hyperglycemic rats. This made us concluded that the TP loaded with C. papaya, C. odorata, and A. bilimbi extract leaves have potential as wound healing agents and could be considered as alternate to the synthetic transdermal patches. HIGHLIGHTS The use of drugs-loaded transdermal patches has been widely studied for the treatment of diabetic wounds, however, the potency of one’s containing Carica papaya, Chromolaena odorata, and Averrhoa bilimbi leaf extracts have not been studied. The present study reports the effectiveness of Carica papaya, Chromolaena odorata, and Averrhoa bilimbi impregnated transdermal patches in treating diabetic rat wounds based on CSI score, histological feature of rat skin and TGF- β concentration. GRAPHICAL ABSTRACT

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Section: Groupscontrasting

confidence: 99%

Wound Healing Activity of Transdermal Patches of Carica Papaya, Chromolaena Odorata, and Averrhoa Bilimbi Leaves on Incision Wounds of Hyperglycemic Rat

Santi,

Siregar,

Sutriana

et al. 2023

Trends Sci

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“…36 TGF-β is a growth factor that plays a key role in wound healing by stimulating fibroblasts and is predominantly involved in increasing collagen synthesis. 37 In vivo studies have shown that curcumin mediates the infiltration of fibroblasts into the wound site, which naturally differentiates into myofibroblasts during granulation tissue formation. Treatment with curcumin also promotes the differentiation of fibroblasts into myofibroblasts, marking the initiation of wound contraction.…”

Section: Discussionmentioning

confidence: 99%

The effect of 5% Curcuma xanthorrhiza extract gel on diabetic rat socket: A fibroblast analysis

Anggayanti,

Purbasari,

Wahyuni

2024

Dent. J.

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Background: Predominant advanced glycation end products (AGEs) in diabetes mellitus (DM) patients lead to increased reactive oxygen species, causing oxidative stress and cell apoptosis, which hinders wound healing. Curcuma xanthorrhiza contains active compounds such as curcumin, flavonoids, and saponins, which can increase fibroblast cell production, the primary indicator of wound healing, and serve as AGE inhibitors. Purpose: This study aimed to determine the effect of 5% C. xanthorrhiza extract gel on the number of fibroblasts in diabetic Wistar rats during the healing of tooth extraction over a specific duration. Methods: The left mandibular incisor was extracted after using alloxan to induce diabetes in the rats. The socket was then treated with different compounds, including 5% C. xanthorrhiza extract gel, placebo CMC-Na, or Gengigel. A histopathological examination of the socket was conducted to assess the presence of fibroblasts on days one, three, and five after treatment. Results: The number of fibroblasts in the sockets treated with 5% C. xanthorrhiza extract gel was lower than in the Gengigel group but higher than in the placebo group (p < 0.05). Conclusion: 5% C. xanthorrhiza extract gel can increase the number of fibroblasts, thereby potentially accelerating wound healing in DM.

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“…(Susetyowati et al, 2010). Gizi terutama kandungan kolagen meningkatkan penyembuhan luka (Wulandari et al, 2021). Faktor penghambat penyembuhan luka perlu dikendalikan, diantaranya faktor penghambatnya adalah diabetes melitus, sehingga edukasi diabetes melitus diharapkan dapat mengendalikan kadar glukosa darah (Lede et al, 2018).…”

Section: Metodeunclassified

Penguatan Pelayanan Kesehatan Nci Centre Kalimantan melalui Digitalisasi Pemasaran pada Masa Pandemi Covid-19

Sukmana

Hamka²,

Muldani

et al. 2023

Creat J. Cumn Enga

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ABSTRAK Pada masa pandemi covid-19 terjadi perubahan strategi pelayanan kesehatan khususnya UMKM bidang kesehatan. NCI Center salah satu UMKM bidang kesehatan telah memberikan pelayanan perawatan luka, stoma, dan inkontinesia selama pandemi ini melakukan perubahan pada manajemen keuangan disituasi pandemi, adaptasi dalam rekam asuhan keperawatan dan digitalisasi pemasaran. Perubahan ini dilakukan agar lebih adaptif memberikan pelayanan kesehatan dalam situasi pandemi. Pengabdian masyarakat ini bertujuan meningkatkan kualitas rekam asuhan keperawatan, meningkatkan kualitas manajemen keuangan, dan digitalisasi marketing melalui peningkatan layanan digital. Tahapan kegiatan pengabdian masyarakat meliputi: analisis masalah dan kebutuhan di NCI Centre, pengambilan data rekam riwayat kesehatan, analisis menajemen keuangan dan pembuatan produk digitalisasi pemasaran. Pengambilan data rekam riwayat kesehatan pasien, Pengumpulan data melalui observasi, wawancara baik yang berhubungan dengan manajemen sistem penjualan dan sistem pembukuan keuangan secara syariah. manajemen sistem penjualan dan sistem pembukuan keuangan secara syariah. Digitalisasi marketing melalui lima video yang dipublish pada media sosial, tiga Katalog, dan 100 flayer media marketing. Edukasi sikap caring dalam merawat pasien luka. Pembuatan aplikasi Food Recall 24 Jam dan pendaftaran Hak Merek Logo NCI Centre. Pengabdian masyarakat melalui kegiatan rekam asuhan keperawatan, manajemen keuangan, dan digitalisasi marketing dapat meningkatkan pelayanan fasilitas kesehatan di NCI Centre pada masa pandemi covid-19. NCI Centre dapat meningkatkan pelayanan kesehatan melalui pengembangan website. Kata Kunci: UMKM, NCI Centre, Digitalisasi Marketing ABSTRACT During the Covid-19 pandemic, there was a change in the strategy of health services, especially MSMEs in the health sector. The NCI Center, one of the UMKM in the health sector, has provided wound, stoma, and incontinence care services during this pandemic, making changes to financial management in a pandemic situation, adapting nursing care records, and digitizing marketing. This change was made to be more adaptive in providing health services in a pandemic situation. This community service aims to improve the quality of nursing care records, improve the quality of financial management, and digitize marketing through improving digital services. Stages of community service activities include: analysis of problems and needs at the NCI Center, retrieval of medical history data, analysis of financial management, and manufacture of marketing digitalization products. The results of the activities include retrieval of patient medical history record data, data collection through observation, and interviews both related to the management of the sales system and the sharia financial accounting system. sales system management and syariah financial accounting system. Digitizing marketing through five videos published on social media, three catalogs, and 100 media marketing flyers. Caring attitude education in caring for injured patients. Making the 24-hour Food Recall application and registering the NCI Center Logo Brand Rights. Community service through nursing care recording activities, financial management, and digital marketing can improve health facility services at the NCI Center during the Covid-19 pandemic. The NCI Center can improve health services through website development. Keyword: UMKM, NCI Centre, digitalisasi marketing

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Deteksi Kadar Transforming Growth Factor (Tgf-Β) Pada Luka Akut

Cited by 3 publications

References 2 publications

Wound Healing Activity of Transdermal Patches of Carica Papaya, Chromolaena Odorata, and Averrhoa Bilimbi Leaves on Incision Wounds of Hyperglycemic Rat

Wound Healing Activity of Transdermal Patches of Carica Papaya, Chromolaena Odorata, and Averrhoa Bilimbi Leaves on Incision Wounds of Hyperglycemic Rat

The effect of 5% Curcuma xanthorrhiza extract gel on diabetic rat socket: A fibroblast analysis

Penguatan Pelayanan Kesehatan Nci Centre Kalimantan melalui Digitalisasi Pemasaran pada Masa Pandemi Covid-19

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