DETECTION OF WEAK AND "INCOMPLETE" Rh AGGLUTININS: A NEW TEST

Incidence of Kell blood group in Kashmiri population attending blood bank SKIMS as donors

“…The K gene and its antigenic product are almost entirely confined to the white or Caucasian people, and Jsa to the Negroid or African ones. [7] The Kell blood group system is an interesting mix of high-frequency and low-frequency antigens. It consists of 25 antigens, which include six pairs of triplets of antithetical antigens.…”

“…People without Kell antigens (K0) must be transfused with blood donors who are also K0 to prevent hemolysis. [7][8][9][10] The importance of the association of Kell and XK was deduced from studies on the K0-null, McLeod phenotypes and recognition of the clinical symptoms that accompany the McLeod phenotype. Isolation of Kell and XK proteins from red blood cells, with specific allo-immune antibodies, demonstrated that Kell antigens are carried on a 93 kDa protein and KX on a protein that migrates on SDS-PAGE as a 37 kDa polypeptide.…”

Renal Failure after Administration of Apparently Compatible Blood

“…However, when the red-cell suspensions were prepared with AB serum instead of saline there was agglutination of the Rh-positive but not of the Rh-negative cells. Although no agglutination of the Rhpositive cells occurred in the saline suspension, these cells showed that they had been sensitized by a rhesus antibody when tested by the indirect anti-human globulin reaction (Coombs et al, 1945).…”

Serological Investigations into Sequelae of Scarlet Fever with Particular Reference to Rheumatic Fever

“…Coombs test was carried out (Coombs, Mourant and Race, 1945). Atypical anti-erythrocyte agglutinins: agglutinating and conglutinating (in 6% dextran solution) auto-and isoantibodies at +40, +220 and +37°C.…”