Incidence of Kell blood group in Kashmiri population attending blood bank SKIMS as donors

Shah, Mohd Younus; Shah, Faisal Younis; Shah, Faizan Younus

doi:10.4103/1755-6783.116508

Cited by 2 publications

(5 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results match with those of Shah et al (91.70% vs. 85.18%) and Ashraf et al who also observed K to be significantly frequent among blood group A as compared to B. 11,14 While Rani et al in India observed no marked difference (3.49% vs. 3.23%). 15 To conclude, we observed Kell antigens K and k in 3.6% and 96.3% of blood donors respectively presenting at blood banks of Sheikh Zayed Hospital, Lahore and Jinnah Hospital, Lahore.…”

Section: Discussionsupporting

confidence: 92%

“…Shah et al in 2013 also observed similar male predominance among blood donors (85% Males; vs. 15% Females) in Kashmir. 11 On the other hand, Mustafa et al in 2014 reported nearly equal proportion of donors from both genders (54% Males vs.46% Females) in Saudi Arabia. 12 This male predominance in our society can be attributable to poor nutritional and health status of women in general along with myths and phobias about the blood donation and educational status of population.…”

Section: Discussionmentioning

confidence: 98%

“…Shah et al however observed O (35.6%) to be the most common blood group among Kashmiri population followed by B (32.1%), A (24.1%) and AB (8.2%). 11 This difference can be due to genotypic differences among populations. k antigen (Cellano) was found in 185 (96.3%) donors.…”

Section: Discussionmentioning

confidence: 99%

“…Compared to Shah et al (0.3%) in Kashmir, we observed much higher frequency of K antigen in Pakistani donors. 11 This higher frequency of K in local population and lack of screening and matching can partly explain the increased frequency of hemolytic transfusion reactions noticed in the common practice. It can be thus advocated on the basis of our study, that Kell blood group antigens should be routinely screened and cross-matched; to reduce the risk of such transfusion related reactions in future practice.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Kell Blood Group Antigens in the Blood Donors Attending Blood Banks of Tertiary Care Hospitals of Lahore, Pakistan.

Fatima¹,

Aziz²,

Rehman³

et al. 2019

TPMJ

View full text Add to dashboard Cite

Introduction: Among the complications of blood transfusion, Hemolytic transfusion reactions (HTRs) and Hemolytic disease of the newborn (HDN) are particularly important. Literature reports frequency of HTRs and related mortality up to 1/76,000 and 1/1.8 million units transfused respectively. These hemolytic reactions are caused by incompatibility between the donor and recipient blood and in cases of HDN, due to feto-maternal incompatibility due to maternal antibodies attacking the fetal red cells. Anti-K antibody is the most common antibody encountered in blood banks after the ABO and Rh antibodies. So routine screening and matching of these blood antigens along with ABO and Rh can further reduce the risk of HTRs and HDN. Existing literature on Kell blood system reports varying frequency of K and k antigens among various populations. Objectives: The objectives of this study were to determine the prevalence of Kell blood group antigens in the blood donor population at Shaikh Zayed and Jinnah Hospitals Lahore and the association of Kell blood group antigens with different ABO blood groups of Lahore population. Study Design: It is a descriptive cross-sectional study. Setting: Research was conducted at the Blood banks of Sheikh Zayed Hospital, Lahore and Jinnah Hospital, Lahore. Period: 6 months after the approval of synopsis from 15/06/2015 to 15/12/2015. Material and Methods: This study included 192 donors; 96 from Sheikh Zayed Hospital, Lahore and 96 from Jinnah Hospital, Lahore. A written informed consent was taken from every donor. Kell blood group antigens K and k were determined. Results: There were 192 donors, 96 each from Shaikh Zayed Hospital, Lahore and Jinnah Hospital, Lahore. Out of these donors 186 (96.9%) were males and 6 (3.1%) were females. The most frequent ABO blood group antigen observed was B, which was seen in 82 (42.7%) donors, followed by O in 68 (35.4%), A in 36 (18.8%) and AB in 06 (3.1%) donors. Kell antigen k was found in 185 (96.3%) donors while K was found in 07 (3.6%) donors. When stratified, there was no statistically significant difference in the frequency of Kell antigens between genders (p=0.08) and ABO blood groups (0.09). The frequency of k antigen was higher among those with blood group B (43.2% vs. 17.8%) as compared to A, and the frequency of K antigen was higher among those with blood group A (42.8% vs. 28.5%) as compared to B, however, this was statistically insignificant. Conclusion: The frequency of k was observed to be 96.3%. It was higher in donors with antigen B while the frequency of K was found to be 3.6% and it was higher in donors with antigen A.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Kell Blood Group Antigens in the Blood Donors Attending Blood Banks of Tertiary Care Hospitals of Lahore, Pakistan.

Fatima¹,

Aziz²,

Rehman³

et al. 2019

TPMJ

View full text Add to dashboard Cite

show abstract

“…Kell blood group system is the next most clinically significant after the ABO and Rhesus blood group system [ 27 ]. Antibodies to the Kell antigen have been incriminated in HDFN and in haemolytic transfusion reactions [ 28 – 30 ]. Anti-K typically presents as IgG class alloantibody.…”

Section: Resultsmentioning

confidence: 99%

Distribution of Kell phenotype among pregnant women in Sokoto, North Western Nigeria

Erhabor¹,

Ladan²,

Zama³

et al. 2015

Pan Afr Med J

View full text Add to dashboard Cite

IntroductionKell antigen is highly immunogenic and is the common cause of antibody production in mismatched blood transfusions, haemolytic transfusion reaction (HTR) and maternal alloimmunization, which causes severe anaemia in neonates. The aim of this study is to determine the prevalence and ethnic variation of the Kell phenotype among pregnant women in Sokoto, Nigeria.MethodsKell antigen status of 150 pregnant women aged 18-45 years and mean age 27.19 ±4.69 years attending antenatal clinic in UDUTH Sokoto Nigeria was determined using the conventional tube method and anti-Kell reagents (Lorne Laboratories, UK).ResultsAmong the 150 subjects studied, 3 (2.0%) of subjects were positive and 147 (98.0) were negative for K antigen. Of the 150 pregnant subjects; 32 (21.3%) were primigravidae while 118 (78.7%) were multigravidae. Kell phenotype was more prevalent among primigravidae (3.1%) compared to multigravidae (1.7%) women. The distribution of Kell phenotype among the pregnant subjects was compared based on ethnicity. The prevalence of Kell antigen was significantly higher among the Hausa ethnic group (3.2%) compared to other ethnic groups which indicated zero prevalence (p = 0.001). Kell negative phenotype was ≥ 96.8% among all the ethnic groups.ConclusionOur observed prevalence of Kell phenotype is consistent with previous studies among Blacks and Asians but significantly lower than values observed in previous studies among Caucasians. We recommend that all pregnant women should be screened for the presence clinically significant red cell antigens including Kell antigen on their first antenatal visit. Kell negative red cell should be routinely provided for all pregnant women and women with child bearing potential to reduce the risk of Kell-associated HDFN. There is need to introduce routine screening of pregnant women for clinically significant red cell antibodies to facilitate the effective management of HDFN as well as prevent HTR. There is also need for sustained health education of pregnant women in the area to encourage early booking for antenatal care.

show abstract

Incidence of Kell blood group in Kashmiri population attending blood bank SKIMS as donors

Abstract: Purpose:To determine anti-Kell in Kashmiri population. Material and Methods: Prospective study of One Year.Result: Six patients were tested positive. Conclusion: The incidence of Kell is very low i.e., 0.03% and correlates to the incidence of Japanese.

Cited by 2 publications

References 6 publications

Kell Blood Group Antigens in the Blood Donors Attending Blood Banks of Tertiary Care Hospitals of Lahore, Pakistan.

Kell Blood Group Antigens in the Blood Donors Attending Blood Banks of Tertiary Care Hospitals of Lahore, Pakistan.

Distribution of Kell phenotype among pregnant women in Sokoto, North Western Nigeria

Contact Info

Product

Resources

About