Detection of Thoracolumbar Vertebral Body Destruction with Lateral Spine Radiography Part I

Haller, J O; André, Michael P.; Resnick, D; Miller, Craig W.; Howard, Brian A.; Mitchell, Michael J.; Schils, Jean; Sartoris, David J.; Trudell, Debra

doi:10.1097/00004424-199005000-00008

Cited by 13 publications

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“…Leaving osteoporotic fractures out of consideration, Doyle et al [5] found none of the criteria mentioned in the introduction (above) reliable for assessing changes in bone density in the course of osteoporosis in vivo. Experimental studies in which focal lesions were produced in vertebral bodies to explore the detectability of osteolytic lesions confirmed the difficulties in identifying focal bone loss even when the surrounding tissue was normal [1,10,11]. This further underscores the relatively poor sensitivity of plain radiography for detecting bone loss.…”

Section: Discussionmentioning

confidence: 73%

Interobserver variation in the detection of osteopenia by radiography and comparison with dual X-ray absorptiometry of the lumbar spine

et al. 1994

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In 100 patients (20 male, 80 female) radiographs of the lumbar spine were obtained in both planes, anteroposterior and lateral. Nine readers independently and without specific criteria or training assessed the radiographs for presence of osteopenia in the form of a binary decision. A posteranterior dual x-ray absorptiometry (PA DXA) measurement of the lumbar spine was performed in all patients using the Hologic QDR 1000 bone densitometer. A bone mineral density (BMD) of 0.83 g/cm2 (T-score about 2 SD and 2.5 SD lower than BMD in normal young female and male subjects respectively) was used as a threshold for the diagnosis of osteopenia. Complete agreement amongst the 9 readers was achieved in 43 patients. In 26 more patients at least 8 readers agreed. kappa-coefficients for interobserver variation ranged from 0.458 to 0.691 for reader pairs. For agreement between the observer ratings and the DXA results, kappa-coefficients ranging between 0.347 and 0.555 were found. The vast majority of readers agreed in the diagnosis of osteopenia in cases where the BMD was less than 0.73 g/cm2. Where the BMD was between 0.73 and 1.03 g/cm2 a substantial disagreement was found between reader evaluation and DXA measurement, and also amongst the readers. We conclude from our results that osteopenia can reliably be detected from lumbar spine radiographs by all readers only after a substantial amount of BMD is lost. On the other hand, a diagnosis based solely on PA DXA measurement of the spine may also lack accuracy, due to a substantial influence of degenerative changes of the lumbar spine and aortic calcification.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 73%

Interobserver variation in the detection of osteopenia by radiography and comparison with dual X-ray absorptiometry of the lumbar spine

et al. 1994

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“…We chose to compare the femoral neck with the region of the mandibular body because the anatomical structure of the femoral neck is more corticalized and in this respect resembles the mandible, whereas the vertebral structures are predominantly trabecular. 14,15 Bone scintigraphy examination In order to observe any possible functional abnormalities related to remodeling 12 a bone scintigraphy examination was performed. Hence, around 1 ml of radiolabeled agent containing MDP-99m Tc equivalent to 30 mCi was administered endovenously.…”

Section: Bone Densitometry Examinationmentioning

confidence: 99%

Use of the plasma CTX for assessing the bone activity of the mandible among osteopenic and osteoporotic patients

et al. 2010

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The aim of this study was to determine whether the plasma CTX bone remodeling marker is useful for indicating the bone metabolic activity level of the mandible. Thirty-six patients were selected; all were postmenopausal and aged 50 years or over. In accordance with the WHO criteria for osteoporosis, a control group was set up (n = 10) in which the T-score was greater than -1 and a diseased group with Tscore less than -1. Using MDP-99m Tc samples, the radioisotope uptake in the femoral neck (R 2 ) and mandibular body (R 1 ) was analyzed. A third examination was performed using the plasma CTX biochemical bonemodeling marker. The inferential results for the diseased group showed that Ln(R 1 ) presented a statistically significant linear relationship with Ln(CTx) (p = 0.067) and with the T-score (p = 0.018). The plasma CTX bone remodeling marker is useful for monitoring the bone metabolic activity of the mandible.

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“…Plain radiography has a very low sensitivity in the diagnosis of osteoporosis given that bone mineral loss of approximately 30%-50% is required for positive radiographic findings. [4][5][6] The most common radiographic finding in osteoporosis is generalized osteopenia, a nonspecific term that is manifest as increased radiolucency. 7,8 Other common radiographic features of osteoporosis include cortical thinning, accentuation of the weightbearing trabeculae, and vertebral deformity (collapse, anteroposterior wedging, and concave end-plate deformities).…”

Section: E T H O D S F O R T H E M E a S U R E M E N T O F B O N E mentioning

confidence: 99%

Imaging modalities in the assessment of osteoporosis

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Sartoris

2002

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Detection of Thoracolumbar Vertebral Body Destruction with Lateral Spine Radiography Part I

Cited by 13 publications

References 0 publications

Interobserver variation in the detection of osteopenia by radiography and comparison with dual X-ray absorptiometry of the lumbar spine

Interobserver variation in the detection of osteopenia by radiography and comparison with dual X-ray absorptiometry of the lumbar spine

Use of the plasma CTX for assessing the bone activity of the mandible among osteopenic and osteoporotic patients

Imaging modalities in the assessment of osteoporosis

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