Use of the plasma CTX for assessing the bone activity of the mandible among osteopenic and osteoporotic patients

Abstract

The aim of this study was to determine whether the plasma CTX bone remodeling marker is useful for indicating the bone metabolic activity level of the mandible. Thirty-six patients were selected; all were postmenopausal and aged 50 years or over. In accordance with the WHO criteria for osteoporosis, a control group was set up (n = 10) in which the T-score was greater than -1 and a diseased group with Tscore less than -1. Using MDP-99m Tc samples, the radioisotope uptake in the femoral neck (R 2 ) and mandibular body (R 1 ) was analyzed. A third examination was performed using the plasma CTX biochemical bonemodeling marker. The inferential results for the diseased group showed that Ln(R 1 ) presented a statistically significant linear relationship with Ln(CTx) (p = 0.067) and with the T-score (p = 0.018). The plasma CTX bone remodeling marker is useful for monitoring the bone metabolic activity of the mandible.

Managing the care of patients receiving antiresorptive therapy for prevention and treatment of osteoporosis

“…Some studies advocate the use of sCTx for predicting the risk of developing ARONJ, 101,[128][129][130][131][132] while others question its utility. [133][134][135][136][137] Because some recommendations address the use of sCTx, this section will examine the limitations of sCTx as a risk predictor for ARONJ; and will discuss why the panel does not recommend the use of sCTx for ARONJ risk assessment.…”

Aplicações da teriparatida sobre osteonecrose dos maxilares associada ao uso de bifosfanatos na implantodontia: uma revisão integrativa

“…Com a terapia farmacêutica de teriparatida, os níveis de CTX foram reduzidos. (39,40) Atualmente, não há padrão de tratamento para a osteonecrose dos maxilares associada ao uso de bifosfanatos, porém a teriparatida é a medicação que pode ser uma solução promissora. Em dois anos de terapia medicamentosa, o esqueleto repara os microdanos acumulados e recuperando totalmente a estrutura óssea, preservando a anatomia, estética e função total.…”

La prueba CTX como evaluador de riesgo en el diagnóstico y tratamiento de osteonecrosis de los maxilares inducida por el uso de bifosfonatos

“…Avolio et al (22) realizaron un estudio para determinar si el CTX serológico es útil para indicar el nivel de actividad metabólica del hueso mandibular. Seleccionaron treinta y seis pacientes, de los cuales 10 se encontraban sanas y 26 enfermas, todas eran posmenopáusicas y mayores de 50 años o más.…”