Detection of sulfadimethoxine using optical images of liquid crystals

Du, Jiayin; Jiang, Qifeng; Lü, Xing; Chen, Long-Cong; Zhang, Yan; Xiong, Xingliang

doi:10.1039/c8an02049c

Cited by 29 publications

(10 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is used as feed additive for the prevention and treatment of various animal diseases because of its broad-spectrum antibacterial activity. However, the misuse of SDM is associated to severe health hazards; for example, acute haemolytic anemia [124]. Consequently, concerns for SDM residue detection in animal-derived food, especially milk, honey, eggs, meat and other foodstuffs, have been raised.…”

Section: Sulfadimethoxine (Sdm)mentioning

confidence: 99%

Advances in Gold Nanoparticles-Based Colorimetric Aptasensors for the Detection of Antibiotics: An Overview of the Past Decade

Zahra

Ali

et al. 2021

Nanomaterials

View full text Add to dashboard Cite

Misuse of antibiotics has recently been considered a global issue because of its harmful effects on human health. Since conventional methods have numerous limitations, it is necessary to develop fast, simple, sensitive, and reproducible methods for the detection of antibiotics. Among numerous recently developed methods, aptasensors are fascinating because of their good specificity, sensitivity and selectivity. These kinds of biosensors combining aptamer with colorimetric applications of gold nanoparticles to recognize small molecules are becoming more popular owing to their advantageous features, for example, low cost, ease of use, on-site analysis ability using naked eye and no prerequisite for modern equipment. In this review, we have highlighted the recent advances and working principle of gold nanoparticles based colorimetric aptasensors as promising methods for antibiotics detection in different food and environmental samples (2011–2020). Furthermore, possible advantages and disadvantages have also been summarized for these methods. Finally, the recent challenges, outlook, and promising future perspectives for developing novel aptasensors are also considered.

show abstract

Section: Sulfadimethoxine (Sdm)mentioning

confidence: 99%

Advances in Gold Nanoparticles-Based Colorimetric Aptasensors for the Detection of Antibiotics: An Overview of the Past Decade

Zahra

Ali

et al. 2021

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Subsequently, various detection methods were also investigated. Some studies employed the image processing technique (for example, gray values of POM images) [ 15 ], dielectric properties of LC molecules [ 16 , 17 ] and UV-vis/reflection spectra [ 18 , 19 ] to analyze the variations in LC-based biosensors and to replace the naked eye observation. However, sensitivities of these reported works still need to be significantly improved.…”

Section: Introductionmentioning

confidence: 99%

Liquid crystal-amplified optofluidic biosensor for ultra-highly sensitive and stable protein assay

et al. 2021

View full text Add to dashboard Cite

Protein assays show great importance in medical research and disease diagnoses. Liquid crystals (LCs), as a branch of sensitive materials, offer promising applicability in the field of biosensing. Herein, we developed an ultrasensitive biosensor for the detection of low-concentration protein molecules, employing LC-amplified optofluidic resonators. In this design, the orientation of LCs was disturbed by immobilized protein molecules through the reduction of the vertical anchoring force from the alignment layer. A biosensing platform based on the whispering-gallery mode (WGM) from the LC-amplified optofluidic resonator was developed and explored, in which the spectral wavelength shift was monitored as the sensing parameter. The microbubble structure provided a stable and reliable WGM resonator with a high Q factor for LCs. It is demonstrated that the wall thickness of the microbubble played a key role in enhancing the sensitivity of the LC-amplified WGM microcavity. It is also found that protein molecules coated on the internal surface of microbubble led to their interactions with laser beams and the orientation transition of LCs. Both effects amplified the target information and triggered a sensitive wavelength shift in WGM spectra. A detection limit of 1 fM for bovine serum albumin (BSA) was achieved to demonstrate the high-sensitivity of our sensing platform in protein assays. Compared to the detection using a conventional polarized optical microscope (POM), the sensitivity was improved by seven orders of magnitude. Furthermore, multiple types of proteins and specific biosensing were also investigated to verify the potential of LC-amplified optofluidic resonators in the biomolecular detection. Our studies indicate that LC-amplified optofluidic resonators offer a new solution for the ultrasensitive real-time biosensing and the characterization of biomolecular interactions.

show abstract

“…Owing to orientational behavior and the low anchoring energy of LCs, they have been extensively exploited to amplify and transduce the interaction between aptamer and its target into optical signals through a cross-polarizer, which can be observed under a polarized optical microscope [10][11][12][13][14][15][16]. LC biosensing approaches are label-free and can Molecules 2021, 26, 2893 2 of 12 detect various analytes with a simple readout, thus avoiding the problems related to present diagnostic techniques and offering several advantages over other conventional sensing techniques [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Aptamer Laden Liquid Crystals Biosensing Platform for the Detection of HIV-1 Glycoprotein-120

2021

View full text Add to dashboard Cite

We report a label-free and simple approach for the detection of glycoprotein-120 (gp-120) using an aptamer-based liquid crystals (LCs) biosensing platform. The LCs are supported on the surface of a modified glass slide with a suitable amount of B40t77 aptamer, allowing the LCs to be homeotropically aligned. A pronounced topological change was observed on the surface due to a specific interaction between B40t77 and gp-120, which led to the disruption of the homeotropic alignment of LCs. This results in a dark-to-bright transition observed under a polarized optical microscope. With the developed biosensing platform, it was possible to not only identify gp-120, but obtained results were analyzed quantitatively through image analysis. The detection limit of the proposed biosensing platform was investigated to be 0.2 µg/mL of gp-120. Regarding selectivity of the developed platform, no response could be detected when gp-120 was replaced by other proteins, such as bovine serum albumin (BSA), hepatitis A virus capsid protein 1 (Hep A VP1) and immunoglobulin G protein (IgG). Due to attributes such as label-free, high specificity and no need for instrumental read-out, the presented biosensing platform provides the potential to develop a working device for the quick detection of HIV-1 gp-120.

show abstract

Detection of sulfadimethoxine using optical images of liquid crystals

Abstract: An aptamer based liquid crystal biosensor was firstly developed for sulfadimethoxine detection achieving a lower detection limit of 10 μg L−1.

Cited by 29 publications

References 32 publications

Advances in Gold Nanoparticles-Based Colorimetric Aptasensors for the Detection of Antibiotics: An Overview of the Past Decade

Advances in Gold Nanoparticles-Based Colorimetric Aptasensors for the Detection of Antibiotics: An Overview of the Past Decade

Liquid crystal-amplified optofluidic biosensor for ultra-highly sensitive and stable protein assay

Aptamer Laden Liquid Crystals Biosensing Platform for the Detection of HIV-1 Glycoprotein-120

Contact Info

Product

Resources

About