Detection of Subclinical Keratoconus by Using Corneal Anterior and Posterior Surface Aberrations and Thickness Spatial Profiles

Abstract

PURPOSE. To assess the suitability of corneal anterior and posterior surface aberrations and thickness profile data for discrimination between eyes with early keratoconus (KC), fellow eyes of eyes with early KC, and normal eyes. METHODS. Thirty-two eyes (group 1) of 25 patients were newly diagnosed with KC; 17 eyes of 17 patients (group 2) were asymptomatic fellow eyes without clinical signs of KC. One hundred twenty-three healthy eyes of 69 patients were negative control eyes (group 3). Zernike coefficients from anterior and posterior surfaces, data from corneal thickness spatial profiles, and output values of discriminant functions based on wavefront and pachymetry data were assessed by receiver operating characteristic (ROC) curve analysis for their usefulness in discriminating between KC (groups 1, 2) eyes and control eyes. RESULTS. Vertical coma (C(3)(-1)) from the anterior surface was the coefficient with the highest ability to discriminate between groups 2 and 3 (area under the ROC curve [A(z)ROC] = 0.980; cutoff, -0.2 microm). For posterior wavefront coefficients and pachymetry data, A(z)ROC values were lower. Constructing discriminant functions from Zernike coefficients increased A(z)ROC values. The function containing first-surface data reached an A(z)ROC of 0.993; the functions containing posterior surface or pachymetry data had lower A(z)ROC values (0.932 and 0.903, respectively). The function with anterior, posterior, and pachymetry data reached an A(z)ROC of 1.0. CONCLUSIONS. Corneal wavefront and pachymetry data enabled highly accurate distinction of eyes with subclinical keratoconus from normal eyes. Posterior aberrations and thickness spatial profile data did not markedly improve discriminative ability over that of anterior wavefront data alone.

Characterization of corneal structure in keratoconus

“…It may be especially useful for the detection of keratoconus in its incipient stages, although some evidence demonstrates that posterior aberrations as well as thickness of the spatial profile do not markedly improve discriminative ability over that of anterior wavefront alone. 71 It is preferable to use corneal wavefront aberrometry for keratoconus detection rather than total ocular aberration analysis. Total ocular aberrations (global aberrometry) are difficult if not impossible to measure accurately in highly aberrated eyes.…”

A combination of topographic and pachymetric parameters in keratoconus diagnosis

“…In recent years, several topography based diagnostic algorithms have been developed to detect eyes with early keratoconus or forme fruste keratoconus, and the Scheimpflug technology has gained importance for the diagnosis, treatment planning and postoperative follow-up in the area of keratorefractive surgery [9][10][11][12].…”

Four discriminant models for detecting keratoconus pattern using Zernike coefficients of corneal aberrations

“…Thus, these instruments have disadvantages, but parameters from these instruments might classify an unknown subject more precisely by using data of the anterior and posterior corneal surface and corneal thickness maps as explanatory variables. Many measurement parameters are collected, and it must be determined which one will be effective in detecting early KC [38][39][40]. Therefore, we suggest that the methodology of evaluating explanatory variables and discriminant models is also important.…”