Detection of subclinical atherosclerosis in familial hypercholesterolemia using non-invasive imaging modalities

Caballero, Paloma; Alonso, Rodrigo; Rosado, P.; Mata, Nelva; Fernández‐Friera, Leticia; Jiménez-Borreguero, Luis Jesús; Badimon, Lina; Mata, Pedro

doi:10.1016/j.atherosclerosis.2012.02.043

Cited by 44 publications

(29 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Inflamed vulnerable plaques have been associated with a higher prevalence of coronary heart disease 42,43 in the general population and increased circulating Lp-PLA2 levels have been associated with higher plaque vulnerability 8 . Concerning FH, Caballero et al 44 found an increased prevalence of lipid-rich atherosclerotic plaques in FH using magnetic resonance imaging. Moreover, Van Den Oord et al 45 found that FH subjects more frequently exhibited atherosclerotic plaques neovascularization, a sign of plaque vulnerability.…”

Section: Discussionmentioning

confidence: 99%

Lipoprotein-associated phospholipase A₂ activity is increased in patients with definite familial hypercholesterolemia compared with other forms of hypercholesterolemia

Mattina

Rosenbaum

Bittar

et al. 2018

Nutrition, Metabolism and Cardiovascular Diseases

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Lipoprotein-associated phospholipase A₂ activity is increased in patients with definite familial hypercholesterolemia compared with other forms of hypercholesterolemia

Mattina

Rosenbaum

Bittar

et al. 2018

Nutrition, Metabolism and Cardiovascular Diseases

View full text Add to dashboard Cite

“…Our case has drawn attention due to the fact that atherosclerotic lesions were not observed in the aorta, this being the primary site of lesions in patients with FH [12]. Caballero et al [19] observed that all patients with plaques in carotid arteries (5/36) also had plaques in the aorta and, on the other hand, the two FH cases without plaques in the aorta had no plaques in carotid arteries.…”

Section: Discussionmentioning

confidence: 88%

A Case of Severe Carotid Stenosis in a Patient with Familial Hypercholesterolemia without Significant Coronary Artery Disease

Barros¹,

Ferreira-Fernandes

Barros

et al. 2014

Case Reports in Cardiology

View full text Add to dashboard Cite

Familial hypercholesterolemia (FH) is an inherited metabolic disorder characterized by elevated low-density lipoprotein cholesterol levels in the blood. In its heterozygous form, it occurs in 1 in 500 individuals in the general population. It is an important contributor to the early onset of coronary artery disease (CAD), accounting for 5–10% of cases of cardiovascular events in people younger than 50 years. Atherogenesis triggered by hypercholesterolemia generally progresses faster in the coronary arteries, followed by the subsequent involvement of other arteries such as the carotids. Thus, symptoms of CAD commonly appear before the onset of significant carotid stenosis. Herein, we report the case of a patient with untreated FH who had severe carotid atherosclerosis at the age of 46 years but had no evidence of significant CAD.

show abstract

“…The release of inflammatory cytokines and other markers such as Interleukin-1β (IL-1 β ), IL-6, Tumor Necrosis Factor-α, and C-reactive protein may also be reversible. [11,[20][21][22] The Elevated Plus Maze (EPM) test is widely used to investigate the psychological bases of anxiety. Usually an animal without any treatment tends to remain for a longer time in the closed arms that represents an exposition to naturally threatening situations, which in the The presence of substances that reduce anxiety makes the animal feel calmer and consider the environment less threatening.…”

Section: Discussionmentioning

confidence: 99%

Dypteryx Alata Vogel Seeds May Improve Anthropometric and Behavioral Profile of Wistar Rats

Barbalho¹

2017

WJPR

View full text Add to dashboard Cite

Dipteryx alata Vogel (DA), popularly known as baru, is a native tree from the Brazilian Cerrado and belongs to the family Fabaceae. It possesses a seed (almond), covered by a sweet yellow pulp and a brown shell that is rich in proteins, with an important amount of essential amino acids, unsaturated fatty acids, mainly oleic acid, fiber, vitamins and minerals. The objective of this research was to investigate the effects of baru almonds on the anthropometric profile and behavioral of Wistar rats. Animals weighting 180g-220g were divided randomly in G1 (n=10) that was fed water and rat food ad libitum and G2 (n=10) that was fed water and rat food supplemented with DA 40% ad libitum for 40 days. Our results showed that Dipteryx alata reduce food intake and may help prevent the increase in body weight and deposition of visceral fat as well as it may help in the reduction of the anxiety behavior. Baru seeds may play an important role in the agro-

show abstract

Detection of subclinical atherosclerosis in familial hypercholesterolemia using non-invasive imaging modalities

Cited by 44 publications

References 20 publications

Lipoprotein-associated phospholipase A₂ activity is increased in patients with definite familial hypercholesterolemia compared with other forms of hypercholesterolemia

Lipoprotein-associated phospholipase A₂ activity is increased in patients with definite familial hypercholesterolemia compared with other forms of hypercholesterolemia

A Case of Severe Carotid Stenosis in a Patient with Familial Hypercholesterolemia without Significant Coronary Artery Disease

Dypteryx Alata Vogel Seeds May Improve Anthropometric and Behavioral Profile of Wistar Rats

Contact Info

Product

Resources

About