Detection of Stromal Invasion in Breast Cancer: The Myoepithelial Markers

Yaziji, Hadi; Gown, Allen M.; Sneige, Nour

doi:10.1097/00125480-200007020-00005

Cited by 96 publications

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“…However, NGFR expression in myofibroblasts was never as strong as that seen in myoepithelial cells and not as diffuse as that observed with a-smooth muscle actin. 19,21 In the stromal compartment of normal breast and benign and malignant breast lesions, the distribution of NGFR is strikingly similar to that described for CD34. 39,45,46 In fact, NGFR was consistently expressed by intralobular (myo)fibroblasts, stromal cells of benign biphasic neoplasms and in pseudoangiomatous stromal hyperplasias, but largely negative in the stromal compartment of invasive tumours.…”

Section: Discussionsupporting

confidence: 62%

“…Out of these cases, 10 showed expression of basal/myoepithelial markers (ie, Ck5/6, Ck14, Ck17 and EGFR). 19,21,26,27,30,31 Although NGFR showed no prognostic significance in this cohort, when its expression was analysed in a cohort of 37 basal-like breast carcinomas, 26 NGFR showed a statistically significant association with lack of lymph node metastasis. In addition, initial analysis in 37 basal-like breast carcinomas has revealed statistically significant associations between NGFR expression and longer disease-free and overall survival.…”

Section: Discussionmentioning

confidence: 77%

“…For example, distinguishing ductal carcinoma in situ (DCIS) vs invasive ductal carcinoma, radial scar vs infiltrating tubular carcinoma, cancerisation of sclerosing adenosis by DCIS mimicking invasive breast carcinoma, adenoid cystic carcinoma vs collagenous spherulosis or cribriform DCIS, papillary carcinoma vs papilloma, and nipple adenoma vs invasive ductal carcinoma. [18][19][20][21] In recent years, several myoepithelial markers have been described, most of them either related to the basal nature of myoepithelial cells or to the smooth muscle apparatus of these cells. [18][19][20][21][22] However, the development of novel myoepithelial markers is not only important for diagnostic purposes but also for prognostication.…”

mentioning

confidence: 99%

“…[18][19][20][21] In recent years, several myoepithelial markers have been described, most of them either related to the basal nature of myoepithelial cells or to the smooth muscle apparatus of these cells. [18][19][20][21][22] However, the development of novel myoepithelial markers is not only important for diagnostic purposes but also for prognostication. There are several lines of evidence to suggest that highgrade breast carcinomas expressing basal/myoepithelial markers have distinct pathological features, expression profiles and, most importantly, clinical behaviour when compared to high-grade breast carcinomas devoid of basal-like differentiation.…”

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confidence: 99%

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Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue

et al. 2006

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Nerve growth factor receptor (NGFR) is a transmembrane glycoprotein without intrinsic tyrosine kinase activity, whose expression is not restricted to neural cells. NGFR is reported to act as a tumour suppressor, negatively regulating cell growth and proliferation. NGFR expression was immunohistochemically analysed in normal breast tissue and in 140 benign, biphasic and preinvasive breast lesions, in 22 tumours with myoepithelial differentiation and in two cohorts of breast cancer patients: a series of 245 invasive breast carcinomas studied with tissue microarrays and 37 high-grade invasive ductal carcinomas with basal-like immunophenotype. NGFR consistently displayed membrane reactivity in myoepithelial cells arranged as a continuous layer around normal ducts and lobular units, intralobular fibroblasts, vascular adventitia and nerve bundles. Myoepithelial cells of benign proliferations and pre-invasive lesions were consistently positive for NGFR. Scattered NGFRpositive cells were observed in solid areas of six out of nine cases of hyperplasia of usual type, whereas in flat atypia, lobular carcinoma in situ and virtually all cases of ductal carcinoma in situ (97.5%), NGFR was restricted to the myoepithelial layer. Positivity for NGFR was observed in 11 out of 245 (4.5%) breast carcinomas, nine out of 20 (45%) metaplastic breast carcinomas and 14 out of 37 (38%) basal-like breast carcinomas. NGFR expression in invasive tumours significantly correlated with that of cytokeratins 5/6 (Po0.05), 14 (Po0.0001) and 17 (Po0.0005) and EGFR (Po0.0001) and displayed an inverse correlation with oestrogen and progesterone receptors (both, Po0.0001). NGFR showed a statistically significant association with longer disease-free (Po0.05) and overall survival (Po0.01) in the cohort of patients with basal-like carcinomas. This study demonstrates the usefulness of NGFR as a new adjunct marker to identify myoepithelial cells in preinvasive lesions and myoepithelial differentiation in breast carcinomas. Furthermore, provisional data in a small number of basal-like breast carcinomas suggest that NGFR may identify a subgroup of basal-like breast carcinomas with good prognosis.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 77%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue

et al. 2006

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“…Normal breast glands and ducts are composed of 3 cell types that express different subsets of proteins: luminal, basal, and myoepithelial [1,2]. The luminal and basal cell types express different cytokeratins (CKs); myoepithelial cells (MECs) express basal cell-type CKs and other more specific markers, such as smooth muscle actin, calponin, and p63.…”

Section: Introductionmentioning

confidence: 99%

Comparative Immunohistochemical Study of P63, SMA, CD10 and Calponin in Distinguishing In Situ from Invasive Breast Carcinoma

Abdallah¹,

Deeb²

2017

J Mol Biomark Diagn

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Breast ductal carcinoma in situ with microinvasion

Mascarel

MacGrogan

Mathoulin‐Pélissier

et al. 2002

Cancer

101

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BACKGROUND The significance of microinvasion is still debated and clinical management is controversial. The authors defined ductal carcinoma in situ with microinvasion (DCIS‐MI) as DCIS with infiltration of the periductal stroma by a few tumor cells, singly (type 1) or in clusters (type 2). With this definition, the authors attempted to evaluate the clinical significance of microinvasion. METHODS The authors compared the clinical, pathologic features, and survival (median follow‐up, 7.3 years) of 1248 patients with, respectively, DCIS (722 patients), DCIS‐MI with microinvasion type 1 and type 2 (243 patients), and invasive ductal carcinoma in situ with a predominant DCIS component greater than or equal to 80% of the tumor (IDC‐DCIS, 283 patients). RESULTS Microinvasion was associated with DCIS histologic type, grade, and extent (respectively, P < 10−8, P < 10−3, P < 10−4). Axillary lymph node metastases were observed in a few patients with DCIS and DCIS‐MI type 1 (respectively, 1.4% and none), in 10.1% with DCIS‐MI type 2 and in 27.6% with IDC‐DCIS. Metastasis free and overall survival probabilities were significantly different between three groups in the following order from best to worst prognosis: 1) the group comprising DCIS and DCIS‐MI type 1, 2) the DCIS‐MI type 2 group, and 3) the IDC‐DCIS group. CONCLUSIONS The authors' results suggest there are two types of DCIS‐MI: 1) type 1 that behaves like DCIS and should be managed as such; 2) type 2 that is less pejorative than IDC‐DCIS but is more so than type 1. Cancer 2002;94:2134–42. © 2002 American Cancer Society. DOI 10.1002/cncr.10451

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Detection of Stromal Invasion in Breast Cancer: The Myoepithelial Markers

Cited by 96 publications

References 0 publications

Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue

Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue

Comparative Immunohistochemical Study of P63, SMA, CD10 and Calponin in Distinguishing In Situ from Invasive Breast Carcinoma

Breast ductal carcinoma in situ with microinvasion

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