“…Caveolin-1, a major component of caveolar membranes consistently expressed in myoepithelial cells (Hurlstone et al, 1999;Jones et al, 2004b), which is reported to have both tumour suppressive and oncogenic properties depending on the context (Hurlstone et al, 1999;Hnasko and Lisanti, 2003;Williams and Lisanti, 2005), has been shown to be expressed in a subset of basal-like and BRCA1 tumours (Charafe-Jauffret et al, 2006;Pinilla et al, 2006). Other interesting proteins preferentially expressed in myoepithelial cells and basal-like tumours are fascin (Rodriguez-Pinilla et al, 2006), osteonectin (Jones et al, 2004b;Lakhani et al, 2005), p-cadherin (Arnes et al, 2005;Jacquemier et al, 2005;CharafeJauffret et al, 2006), 14-3-3 sigma (Simpson et al, 2004), maspin (Jones et al, 2004b), alpha-beta-crystallin (Jones et al, 2004b;Moyano et al, 2006) and p75 nerve growth factor receptor (NGFR) (Reis-Filho et al, 2006d); the latter two markers appear to identify prognostically significant subgroups of basal-like breast cancers. Alpha-b-crystallin is expressed in basal-like breast cancers with pathological features suggestive of a more aggressive clinical behaviour (Moyano et al, 2006), whereas NGFR has recently been shown to be expressed in a subset of basal-like breast carcinomas with less frequent lymph node metastasis and a longer overall survival (Reis-Filho et al, 2006d).…”