Detection of smoke‐induced pulmonary lesions by hyperpolarized ¹²⁹Xe diffusion kurtosis imaging in rat models

Abstract

DKI with hyperpolarized xenon exhibited sensitivity in the detection of pulmonary lesions induced by smoke, including moderate emphysema and small airway diseases. The critical b value was rarely exceeded in DKI of the lungs due to the limited gradient strength of the MRI scanner used in our study. Magn Reson Med 78:1891-1899, 2016. © 2016 International Society for Magnetic Resonance in Medicine.

Lung morphometry using hyperpolarized 129Xe multi‐b diffusion MRI with compressed sensing in healthy subjects and patients with COPD

“…Furthermore, with a combination of CS and PI techniques in the future, the scan time could be reduced further, and the image resolution could also be improved. In addition, the method could also be combined with other models such as the q‐space, stretched exponential, and diffusion kurtosis imaging (DKI) models to probe lung microstructure. Hence, HP 129 Xe multi‐ b diffusion MRI with CS has great potential for clinical applications, and it could be applied perfectly well in subjects with lung diseases who may be unable to hold their breath for a long time.…”

Quantitative evaluation of lung injury caused by PM2.5 using hyperpolarized gas magnetic resonance

“…Eight b values (4, 8, 12, 16, 20, 24, 28, and 32 s/cm 2 ) were used to fit the nonmonoexponential signal decay. In order to correct the influence of decreased xenon signal caused by radiofrequency excitation and T 1 relaxation on the diffusion‐weighted images, interleaved sampling strategy was used, and the images were acquired for a given line of k‐space in the order of b = 0, x, 0 s/cm 2 . Accordingly, for each b value, 3 images were collected in a single breath‐hold with a duration of 4 seconds after lungs were flushed once using hyperpolarized xenon gas.…”

“…A standard test grid was overlaid on the image; septal thickness was determined as the average of the total truncated length . For each rat, 18 images were used to automatically calculate alveolar septal thickness by Image‐Pro Plus software (Media Cybernetics, Buckinghamshire, UK) …”

“…Generally, hyperpolarized 129 Xe ventilation imaging could be utilized to quantify pulmonary ventilation defects in the lungs . By applying models of diffusion, changes in the pulmonary microstructure caused by lung diseases, such as COPD, can be quantified by multi‐ b diffusion‐weighted imaging (DWI) and diffusion kurtosis imaging . Additionally, hyperpolarized 129 Xe MR has unique advantages in exploring the gas exchange function of the lungs attributed to the increased chemical sensitivity to its surrounding environment and high solubility in tissue and blood.…”