Detection of Sheep-Associated Malignant Catarrhal Fever Virus Antibodies by Complement Fixation Tests.

Sentsui, Hiroshi; Nishimori, Tomoko; Nagai, Izumi; Nishioka, Nobuyoshi

doi:10.1292/jvms.58.1

Cited by 14 publications

(14 citation statements)

References 14 publications

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“…Interviews with farmers revealed that no previous investigations on this pathogen had been carried out in any of the randomly selected sampling units for this study. Thus, this research provides The seroprevalence of OvHV-2 infection reported in the present study (37.66%) was lower when compared to that of the previous study conducted in Japan (64.3%) [22]. In the U.S.A., OvHV-2 was associated with 53 to 59% of serologically positive sheep [12], while seropositivity in Germany was reported prevalence as 75% [7], and that of the Middle East, which was greater than 70 to 95% [5].…”

Section: Malignant Catarrhal Fever (Mcf) Is An Infectious Disease Of contrasting

confidence: 63%

“…Only one previous study showed the presence of OvHV-2 in sheep in Japan [22], and this study reported a seroprevalence of 64.3% in 238 samples from sheep originating from 10 farms in the Hokkaido prefecture. No further investigation has been reported.…”

Section: Malignant Catarrhal Fever (Mcf) Is An Infectious Disease Of mentioning

confidence: 49%

“…The lower prevalence reported in this study might be due to use of the SN test, which is different from the tests used in other studies. For example, the complement fixation test was used in the previous study conducted in Japan [22], an enzyme-linked immunosorbent assay was used to detect OvHV-2 antibodies in the studies performed in the U.S.A. and Germany [7,12], and PCR was used to detect OvHV-2 antibodies in a study performed in Israel [5]. Ideally, a comparison with other tests would increase information about the reliability of the infection rate obtained using the SN assay, but this was outside the scope of this study.…”

Section: Malignant Catarrhal Fever (Mcf) Is An Infectious Disease Of mentioning

confidence: 99%

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Serological Survey to Determine the Occurrence of Malignant Catarrhal Fever Infection in the Japanese Small Ruminant Population from Northern Districts

Giangaspero

Savini

Osawa

et al. 2013

The Journal of Veterinary Medical Science

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ABSTRACT. Ovine herpesvirus 2 (OvHV-2) causes sheep-associated malignant catarrhal fever (SA-MCF), and is responsible for economic losses in cattle and other susceptible species around the world. A survey of 154 serum samples from 14 flocks in 3 Japanese prefectures (Hokkaido, Aomori and Iwate) was undertaken between 2007 and 2008 to test for antibodies to OvHV-2. OvHV-2 was present in 56 sheep and 2 goats, with 37.66% of samples having a positive reaction using a serum neutralization test. The immune reaction reported in goats could result from Caprine herpesvirus-2. These results indicate that sheep are reservoirs for OvHV-2 in the field in Japan, and they might transmit the virus to susceptible cattle and wild fauna.

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Section: Malignant Catarrhal Fever (Mcf) Is An Infectious Disease Of contrasting

confidence: 63%

Section: Malignant Catarrhal Fever (Mcf) Is An Infectious Disease Of mentioning

confidence: 49%

Section: Malignant Catarrhal Fever (Mcf) Is An Infectious Disease Of mentioning

confidence: 99%

See 1 more Smart Citation

Serological Survey to Determine the Occurrence of Malignant Catarrhal Fever Infection in the Japanese Small Ruminant Population from Northern Districts

Giangaspero

Savini

Osawa

et al. 2013

The Journal of Veterinary Medical Science

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“…Plenty of diagnostic methods have been established to detect viral DNA in tissues and blood or specific antibodies against MCFVs in serum. (Baxter, Pow, Bridgen, & Reid, ; Collins et al, ; Crawford, Li, & O'Toole, ; Cunha, Otto, Taus, Knowles, & Li, ; Dewals et al, ; Fraser, Nettleton, Dutia, Haig, & Russell, ; Hua, Li, & Crawford, ; Kleiboeker et al, ; Li, McGuire, Muller‐Doblies, & Crawford, ; Li et al, ; Muller‐Doblies, Li, Hauser, Adler, & Ackermann, ; Powers et al, ; Sentsui, Nishimori, Nagai, & Nishioka, ; Tomkins, Jonsson, Young, Gordon, & McColl, ; Traul et al, ; VanDevanter et al, ). Although a previous established multiplex real‐time PCR for a panel of five MCFVs proved to be rapid and reliable, in our diagnostic practice and retrospective investigation, a nested pan‐herpesvirus PCR protocol was applied to the samples in the clinic for the following reasons.…”

Section: Discussionmentioning

confidence: 99%

Malignant catarrhal fever: An emerging yet neglected disease in captive sika deer ( Cervus nippon ) herds in China

Zhu

Sun

et al. 2019

Transbound Emerg Dis

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Malignant catarrhal fever (MCF) is a fatal lymphoproliferative disease that represents a serious problem in the deer‐rearing industry. To better understand an MCF‐like disease that has emerged in northern China since 2015, we investigated ten cases by documenting clinical and epidemiological data and analysing causative agents and histopathological changes. In addition, a retrospective screen for Macavirus DNA and a questionnaire‐based survey were conducted. Epizootic MCF in Chinese sika deer herds has emerged with a low morbidity of 3.8% (95% CI: 2.5%–5.1%) and a high mortality of 93.2% (95% CI: 86.6%–99.9%). The disease course varied from 3 to 12 days. Aetiologically, OvHV‐2 was predominant in the MCFV, accounting for most MCF cases (21/23). In contrast, only two CpHV‐2 isolates were phylogenetically closely related to CpHV‐2. Diarrhoea and nasal discharges were the most frequent manifestations, although clinical signs varied in some cases. Pathologically typical lesions of haemorrhage, necrosis and lymphoid cell infiltration were readily observed in a variety of organs. Vasculitis caused by vascular and perivascular lymphoid cell infiltration was common. The retrospective survey suggested a low positive rate (3/275) of MCFV DNA in peripheral blood lymphocytes (PBL). The questionnaire‐based survey suggested the disease was neglected by local veterinarians, who did not acknowledge the risk of co‐rearing deer with reservoir species. Collectively, the emerging epizootic MCF in Chinese sika deer herds remains neglected, emphasizing the urgency of initiating full‐field diagnoses and control strategies.

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“…Sera were tested by ELISA and agar gel immunodiffusion (AGID). The Chiba strain of parapoxvirus, originally isolated from a cow [25], was used as antigen in both assays as described previously [22,26,27]. The significance of the serological test results in relation to age and sex was analysed using χ# and Fisher's exact tests.…”

Section: Discussionmentioning

confidence: 99%

Serological survey of parapoxvirus infection in wild ruminants in Japan in 1996–9

et al. 2001

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The prevalence of parapoxvirus infection was examined in free-ranging wild ruminants in Japan, Japanese serow (Capricornis crispus) and Japanese deer (Cervus nippon centralis), in 1996-9. We collected a total of 151 serum samples from 101 Japanese serows and 50 Japanese deer and tested for antibodies against parapoxvirus by an enzyme-linked immunosorbent assay and an agar gel immunodiffusion test. Overall seroprevalences among Japanese serows were 5/25 (20.0%) in 1996, 4/14 (28.6%) in 1997, 5/32 (15.6%) in 1998 and 2/30 (6.7%) in 1999, respectively. The seroprevalence increased with age but was not affected by sex. No antibodies were detected from any of 50 serum samples taken from Japanese deer. Our results in this study suggest that parapoxvirus infection is widespread among the population of Japanese serows, however, Japanese deer appear to be still free of the disease.

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Detection of Sheep-Associated Malignant Catarrhal Fever Virus Antibodies by Complement Fixation Tests.

Cited by 14 publications

References 14 publications

Serological Survey to Determine the Occurrence of Malignant Catarrhal Fever Infection in the Japanese Small Ruminant Population from Northern Districts

Serological Survey to Determine the Occurrence of Malignant Catarrhal Fever Infection in the Japanese Small Ruminant Population from Northern Districts

Malignant catarrhal fever: An emerging yet neglected disease in captive sika deer ( Cervus nippon ) herds in China

Serological survey of parapoxvirus infection in wild ruminants in Japan in 1996–9

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