Detection of Respiratory Viruses and Atypical Bacteria in Children's Tonsils and Adenoids

Abstract

The tonsils and adenoids of 44 children were analyzed for the detection of respiratory syncytial virus, influenza virus, parainfluenza virus, adenovirus, Chlamydophila pneumoniae, and Mycoplasma pneumoniae. Viruses were detected in 47.7% of the children and 37.3% of the specimens, with adenovirus and parainfluenza viruses being the most frequently detected microorganisms.

Risk factors for bacteremia during and after adenoidectomy and/or adenotonsillectomy

“…30 On the other hand, previous studies have shown that the tonsils in acute rTF are a reservoir for bacteria, even in children who have received repeated courses of theoretically proper antibiotic therapy. 31,32 Our microbiological data are in line with those reported in the literature. In particular, they confirm previous findings of the importance of H. influenzae in causing post-tonsillectomy bacteremia and its frequent presence in the tonsils of children with rTF.…”

Evaluation of amoxicillin plasma and tissue levels in pediatric patients undergoing tonsillectomy

“…Our data are in agreement with previous studies published by independent groups; in particular, Ozdemir, by using the 133Xe clearance technique, showed a statistically significant decrease in blood flow in chronic tonsillitis compared to healthy controls [24], while Blenk reported an insufficient amoxicillin tissue concentration after oral administration in patients with tonsillitis [19]. A fibrous capsule and therefore impaired antibiotic penetration could also explain huge discrepancies in tissue levels between right and left tonsil and, in addition to other pathogenetic factors previously shown, namely biofilm, SBEGA internalization into cells of mucosa and atypical pathogens [25][26][27][28], favour the establishment of chronic tonsillitis.…”

“…Department of ''Amedeo Avogadro'' University of Eastern Piedmont in Novara for elective tonsillectomy. All tonsils were removed by cold dissection tonsillectomy, with a mean surgery time of 20 min (range [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. Previously, patients were treated with 3 doses of amoxicillinclavulanic acid given orally the day before plus a further dose given 2 h before admittance into the operating theatre.…”

The possibilities for the rational pharmacotherapy of adenoiditis in the children

“…А в исследовании L. Drago ии соавт. [17] в 44 образцах ткани аденоидов Chlamydophila pneumoniae обнаружены только в 4,8% слу-чаев, а Mycoplasma pneumoniae не обнаружены вовсе.…”