Detection of Radiographic Abnormalities in Mammograms by Means of Optical Scanning and Computer Analysis

Winsberg, Fred; Elkin, Milton; Macy, Josiah; Bordaz, Victoria; Weymouth, William

doi:10.1148/89.2.211

Cited by 198 publications

(64 citation statements)

References 3 publications

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“…13 The most important work in the computer analysis of mammograms has been in the detection of two important classes of mammographic abnormality: microcalcifications and masses. A great deal of effort has been put into the development of these techniques and they can be made extremely sensitive.…”

Section: Computer Aids For Mammographymentioning

confidence: 99%

Impact of computer-aided detection prompts on the sensitivity and specificity of screening mammography

Taylor

Champness²,

Given-Wilson³

et al. 2005

Health Technol Assess

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTAImpact of computer-aided detection prompts on the sensitivity and specificity of screening mammography This report should be referenced as follows:Taylor P, Champness J, Given-Wilson R, Johnston K, Potts H. Impact of computer-aided detection prompts on the sensitivity and specificity of screening mammography. Health Technol Assess 2005;9(6). Health Technology Assessment is indexed and abstracted in NHS R&D HTA ProgrammeT he research findings from the NHS R&D Health Technology Assessment (HTA) Programme directly influence key decision-making bodies such as the National Institute for Clinical Excellence (NICE) and the National Screening Committee (NSC) who rely on HTA outputs to help raise standards of care. HTA findings also help to improve the quality of the service in the NHS indirectly in that they form a key component of the 'National Knowledge Service' that is being developed to improve the evidence of clinical practice throughout the NHS.The HTA Programme was set up in 1993. Its role is to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined to include all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care, rather than settings of care.The HTA programme commissions research only on topics where it has identified key gaps in the evidence needed by the NHS. Sugge...

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Section: Computer Aids For Mammographymentioning

confidence: 99%

Impact of computer-aided detection prompts on the sensitivity and specificity of screening mammography

Taylor

Champness²,

Given-Wilson³

et al. 2005

Health Technol Assess

View full text Add to dashboard Cite

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“…6Y9 Efforts were made as early as 1967 to develop a CAD system for mammography. 10 These systems are designed to help radiologists make earlier and more accurate detection of such features as suspicious masses (MAs) and microcalcifications (MCs) as well as architectural distortions during screening mammography. Funovics et al 11 showed that the sensitivity for breast cancer detection increases significantly when a radiologist uses a CAD system.…”

Section: Introductionmentioning

confidence: 99%

Effect of Breast Density on Computer Aided Detection

et al. 2005

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Purpose: This study was conducted to assess the clinical impact of breast density and density of the lesion's background on the performance of a computer-aided detection (CAD) system in the detection of breast masses (MA) and microcalcifications (MC). Materials and Methods: A total of 200 screening mammograms interpreted as BI-RADS 1 and suspicious mammograms of 150 patients having a histologically verified malignancy from 1992 to 2000 were selected by using a sampler of tumor cases. Excluding those cases having more than one lesion or a contralateral malignancy attributable to statistical reasons, 127 cases with 127 malignant findings were analyzed with a CAD system (Second Look 5.0, CADx Systems, Inc., Beavercreek, OH). Of the 127 malignant lesions, 56 presented as MC and 101 presented as MA, including 30 cases with both malignant signs. Overall breast density of the mammogram and density of the lesion's background were determined by two observers in congruence (density a: entirely fatty, density b: scattered fibroglandular tissue, density c: heterogeneously dense, density d: extremely dense). Results: Within the unsuspicious group, 100/ 200 cases did not have any CAD MA marks and were therefore truly negative (specificity 50%), and 151/200 cases did not have any CAD MC marks (specificity 75.5%). For these 200 cases, the numbers of marks per image were 0.41 and 0.37 (density a), 0.38 and 0.97 (density b), 0.44 and 0.91 (density c), and 0.58 and 0.68 (density d) for MC and MA marks, respectively (Fisher's t-test: n.s. for MC, p G 0.05 for MA). Malignant lesions were correctly detected in at least one view by the CAD system for 52/56 (92.8%) MC and 91/101 (90.1%) MA. Detection rate versus breast density was: 4/6 (66.7%) and 18/19 (94.7%) (density a), 32/33 (97.0%) and 49/51 (96.1%) (density b), 14/15 (93.3%) and 23/28 (82.1%) (density c), and 2/2 (100%) and 1/3 (33.3%) (density d) for MC and MA, respectively. Detection rate versus the lesion's background was: 19/21 (90.5%) and 36/38 (94.7%) (density a), 34/36 (94.4%) and 59/62 (95.2%) (density b), 8/9 (88.9%) and 20/24 (83.3%) (density c), and 9/10 (90%) and 4/8 (50%) (density d) for groups 2 and 3, respectively. Detection rates differed significantly for masses in heterogeneously dense and extremely dense tissue (overall or lesion's background) versus all other densities (Fisher's t-test: p G 0.05). A significantly lowered FP rate for masses was found on mammograms of entirely fatty tissue. Conclusion: Overall breast density and density at a lesion's background do not appear to have a significant effect on CAD sensitivity or specificity for MC. CAD sensitivity for MA may be lowered in cases with heterogeneously and extremely dense breasts, and CAD specificity for MA is highest in cases with extremely fatty breasts. The effects of overall breast density and density of a lesion's background appear to be similar. KEY WORDS: CAD, breast density, cancer detection INTRODUCTIONM ammography is a well-established method for the early detection of breast cancer. Because ...

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“…The concept of computer-aided diagnosis in mammography has now been around for more than 40 years [1]. Much of the earlier research as well as the first FDA-approved clinical system introduced in 1998 were based on digitized film-screen mammograms.…”

Section: Computer-aided Diagnosismentioning

confidence: 99%

“…As early as 1967, Fred Winsberg from the University of Chicago proposed an algorithm for computer-aided breast cancer detection using digitized film mammograms [1]. Although film digitization can produce high-quality digital mammograms, this process is not only labor intensive and expensive, but primarily does not solve the limitations inherent to film mammography, mainly the narrow dynamic range caused by the non-linear characteristic curve of film.…”

Section: Introductionmentioning

confidence: 99%