Detection of radiation-induced, accelerated atherosclerosis in patients with osteoradionecrosis by panoramic radiography

Friedlander, Arthur H.; Eichstaedt, Ralph M.; Friedlander, Ida K.; Lambert, Paul M.

doi:10.1016/s0278-2391(98)90712-1

Cited by 22 publications

(14 citation statements)

References 27 publications

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“…Friedlander studied panoramic radiographs of 61 patients aged 41 -77 years (mean age: 60.5 years) who had undergone radiotherapy 36 months prior to the study and 61 cases were considered as the control group. Prevalence of atheroma in the group that had radiotherapy was 27.9% which is close to the results of Beckstrom and in control group was 4.9%, somewhat similar to the results of this study [27].…”

Section: Discussionsupporting

confidence: 91%

Evaluation of Positive Predictive Value for Digital Panoramic Radiography in Comparison to Ultrasound in the Diagnosis of Calcified Carotid Atheroma

Ezoddini-Ardakani¹,

Mirzaei²,

Nayer³

et al. 2014

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Aim: Detection of calcified carotid atheroma (CCA) has an important role in reducing the incidence of Cerebro Vascular Accident (CVA). The aim of this study was to evaluate efficacy of panoramic digital radiography in detecting atherosclerosis. Methods: It is descriptive-analytical diagnostic study. The people (22 to 62 years old) were referred to a radiology clinic to perform panoramic radiography for diagnosis of CCA. Individuals who were suspected were introduced to the radiology department of dental school to undergo ultrasound evaluation to CCA. For the 41 patients (55 sides), ultrasound was performed. For data analysis, the Chi-square and Fisher's exact test were used. Results: The prevalence of CCA was 2.43%. The PPV of digital panoramic was 45.5%. There was no significant relationship between age (P = 0.14) and sex (P = 0.539) and PPV of digital panoramic. The PPV of digital panoramic was significantly associated with hypertension (P = 0.032). Conclusion: It seems that panoramic can be used to screen patients with a history of hypertension for atherosclerosis.

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Section: Discussionsupporting

confidence: 91%

Evaluation of Positive Predictive Value for Digital Panoramic Radiography in Comparison to Ultrasound in the Diagnosis of Calcified Carotid Atheroma

Ezoddini-Ardakani¹,

Mirzaei²,

Nayer³

et al. 2014

Health

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“…Increased risk of accelerated atherosclerosis progression after radiation therapy for malignancy has been reported. [23][24][25][26][27] Further, a recent report has shown that continuous low-dose rate irradiation delivered by radioactive stent promotes "atheromatous" neointimal formation. 28 Therefore, a question still remains to be elucidated: Does endovascular radiation have any influence on the progression of atherosclerosis, especially in the adjacent nontarget irradiated segments?…”

Section: Study Limitationsmentioning

confidence: 99%

Three-Dimensional Intravascular Ultrasound Assessment of Noninjured Edges of β-Irradiated Coronary Segments

et al. 2000

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Background-The "edge effect," late lumen loss at the margins of the treated segment, has become an important issue in the field of coronary brachytherapy. The aim of the present study was to assess the edge effect in noninjured margins adjacent to the irradiated segments after catheter-based intracoronary ␤-irradiation. Methods and Results-Fifty-three vessels were assessed by means of 3-dimensional intravascular ultrasound after the procedure and at 6-to 8-month follow-up. Fourteen vessels (placebo group) did not receive radiation (sham source), whereas 39 vessels were irradiated. In the irradiated group, 48 edges (5 mm in length) were identified as noninjured, whereas 18 noninjured edges were selected in the placebo group. We compared the volumetric intravascular ultrasound measurements of the noninjured edges of the irradiated vessels with the fully irradiated nonstented segments (IRS, nϭ27) (26-mm segments received the prescribed 100% isodose) and the noninjured edges of the vessels of the placebo patients. The lumen decreased (6 mm 3 ) in the noninjured edges of the irradiated vessels at follow-up (Pϭ0.001). We observed a similar increase in plaque volume in all segments: noninjured edges of the irradiated group (19.6%), noninjured edges of the placebo group (21.5%), and IRS (21.0%). The total vessel volume increased in the IRS in the 3 groups. No edge segment was subject to repeat revascularization. Conclusions-The edge effect occurs in the noninjured margins of radiation source train in both irradiated and placebo patients. Thus, low-dose radiation may not play an important role in this phenomenon, whereas nonmeasurable device injury may be considered a plausible alternative explanation.

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“…Dental researchers have observed that 21% of patients (n = 33) receiving RT with 50 Gy for a head and neck malignancy have a calcified atheroma on their radiograph 30 months after irradiation 28 and 28% of patients receiving 40 Gy or more and developing osteoradionecrosis of the mandible have evidence of a calcified atheroma on the radiograph 36 months after irradiation. By comparison, only 5% of matched patients attending the same clinics demonstrated calcified atheromas on their panoramic radiographs 29 …”

Section: Discussionmentioning

confidence: 93%

Radiation‐associated carotid artery atherosclerosis: case report and review of contemporaneous literature

Friedlander

Federico²,

Yueh

et al. 2009

Special Care in Dentistry

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Radiation therapy (RT) is a component of the treatment of patients with head and neck malignancies. This therapy may damage the nearby carotid arteries, thereby initiating or accelerating the atherosclerotic process (atheroma formation). Dentists treating patients who have been irradiated should examine the patient's panoramic radiograph for evidence of atheroma-like calcifications, which appear 1.5 to 2.5 cm posterior and inferior to the angle of the mandible. Patients with evidence of such lesions should be referred to their primary care physician with the suggestion that an ultrasound examination of the carotid arteries is indicated.

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Detection of radiation-induced, accelerated atherosclerosis in patients with osteoradionecrosis by panoramic radiography

Cited by 22 publications

References 27 publications

Evaluation of Positive Predictive Value for Digital Panoramic Radiography in Comparison to Ultrasound in the Diagnosis of Calcified Carotid Atheroma

Evaluation of Positive Predictive Value for Digital Panoramic Radiography in Comparison to Ultrasound in the Diagnosis of Calcified Carotid Atheroma

Three-Dimensional Intravascular Ultrasound Assessment of Noninjured Edges of β-Irradiated Coronary Segments

Radiation‐associated carotid artery atherosclerosis: case report and review of contemporaneous literature

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