Detection of Purine Metabolite Uric Acid with Picolinic-Acid-Functionalized Metal–Organic Frameworks

Qu, Shumei; Li, Zheng; Jia, Qingxuan

doi:10.1021/acsami.9b07442

Cited by 71 publications

(42 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, Jia and co-workers designed a fluorescent biosensor based on 2-picolinic acid-modified UiO-66-NH 2 with rapid response, high selectivity and sensitivity for direct detection of uric acid. [86] In this system, the fluorescence of 2-picolinic acid-modified UiO-66-NH 2 was quenched by uric acid via hydrogen bonding, coordination, and π-π interactions. This biosensor could detect uric acid within a linear detection range of 0.01-400 µM and a detection limit of 2.3 nM.…”

Section: Others Biosensingmentioning

confidence: 95%

“…This work provides a promising way for the diagnosis of tumors in clinical laboratory by MOF‐based biosensors. Recently, Jia and co‐workers designed a fluorescent biosensor based on 2‐picolinic acid‐modified UiO‐66‐NH 2 with rapid response, high selectivity and sensitivity for direct detection of uric acid 86. In this system, the fluorescence of 2‐picolinic acid‐modified UiO‐66‐NH 2 was quenched by uric acid via hydrogen bonding, coordination, and π–π interactions.…”

Section: Biomedical Applications Of Mofsmentioning

confidence: 99%

“…In this review article, we will summarize the recent developments of MOF‐based composite materials including the synthesis and functionalization8–15 and their biomedical applications in the delivery of cargos including drugs, nucleic acids, proteins, and dyes ( Table 1 ),19,21–23,25–29,31b,d,34–41 bioimaging ( Table 2 ),43–45,47–54 antimicrobial ( Table 3 ),57,60–67 biosensing ( Table 4 ),69–73,75–86 and biocatalysis ( Table 5 ). 91–95 Moreover, the potential of MOFs for biomedical applications has been clarified through the analysis of recent examples reported in literature.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Metal–Organic Frameworks for Biomedical Applications

Yang

2020

Small

593

376

View full text Add to dashboard Cite

Metal–organic frameworks (MOFs) are an interesting and useful class of coordination polymers, constructed from metal ion/cluster nodes and functional organic ligands through coordination bonds, and have attracted extensive research interest during the past decades. Due to the unique features of diverse compositions, facile synthesis, easy surface functionalization, high surface areas, adjustable porosity, and tunable biocompatibility, MOFs have been widely used in hydrogen/methane storage, catalysis, biological imaging and sensing, drug delivery, desalination, gas separation, magnetic and electronic devices, nonlinear optics, water vapor capture, etc. Notably, with the rapid development of synthetic methods and surface functionalization strategies, smart MOF‐based nanocomposites with advanced bio‐related properties have been designed and fabricated to meet the growing demands of MOF materials for biomedical applications. This work outlines the synthesis and functionalization and the recent advances of MOFs in biomedical fields, including cargo (drugs, nucleic acids, proteins, and dyes) delivery for cancer therapy, bioimaging, antimicrobial, biosensing, and biocatalysis. The prospects and challenges in the field of MOF‐based biomedical materials are also discussed.

show abstract

Section: Others Biosensingmentioning

confidence: 95%

Section: Biomedical Applications Of Mofsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Metal–Organic Frameworks for Biomedical Applications

Yang

2020

Small

593

376

View full text Add to dashboard Cite

show abstract

“…In healthy people, normal levels of UA vary function of the nature of analyzed samples between 0.13 and 0.46 mM in serum, ten times higher 1.49-4.50 mM in urine, and in the range from120 µM to 400 µM in the saliva [2,3].…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Uric Acid Optical Detection Using as Sensitive Materials an Amino-Substituted Porphyrin and Its Nanomaterials with CuNPs, PtNPs and Pt@CuNPs

et al. 2021

View full text Add to dashboard Cite

Hybrid nanomaterials consisting in 5,10,15,20-tetrakis(4-amino-phenyl)-porphyrin (TAmPP) and copper nanoparticles (CuNPs), platinum nanoparticles (PtNPs), or both types (Pt@CuNPs) were obtained and tested for their capacity to optically detect uric acid from solutions. The introduction of diverse metal nanoparticles into the hybrid material proved their capacity to improve the detection range. The detection was monitored by using UV-Vis spectrophotometry, and differences between morphology of the materials were performed using atomic force microscopy (AFM). The hybrid material formed between porphyrin and PtNPs hasthe best and most stable response for uric acid detection in the range of 6.1958 × 10−6–1.5763 × 10−5 M, even in the presence of very high concentrations of the interference species present in human environment.

show abstract

“…Jain et al synthesized the electrochemical sensor based on butylamine capped CZTS for nanoparticles the detection of UA [11]. Moreover, two-dimensional carbon sheets [12], metallic sensors [13] and nanocomposite [14] materials has been synthesized as effective sensors for the detection of uric acid.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Sensing Behavior of Graphdiyne Nanoflake Toward Uric Acid; A Quantum Chemical Approach

Asif

Sajid

Ayub

et al. 2021

Preprint

View full text Add to dashboard Cite

Though, the gas sensing applications of graphdiyne have widely reported; however, the biosensing utility of graphdiyne needs to be explored. This study deals with the sensitivity of graphdiyne nanoflake (GDY) towards the uric acid (UA) within the density functional framework. The uric acid is allowed to interact with graphdiyne nanoflake from all the possible orientations. Based on these interacting geometries, the complexes are differentiated with naming i.e., UA1@GDY, UA2@GDY, UA3@GDY and UA4@GDY (Figure 1). The essence of interface interactions of UA on GDY is derived by computing geometric, energetic, electronic and optical properties. The adsorbing affinity of complexes is evaluated at ωB97XD/6-31+G(d,p) level of theory. The stabilities of the complexes are quantified through the interaction energies (Eint) with reasonable accuracy. The calculated Eint of the UA1@GDY, UA2@GDY, UA3@GDY and UA4@GDY complexes are -31.13, -25.87, -20.59 and -16.54 kcal/mol, respectively. In comparison with geometries, it is revealed that the higher stability of complexes is facilitated by π-π stacking. Other energetic analyses including symmetry adopted perturbation theory (SAPT0), noncovalent interaction index (NCI) and quantum theory of atoms in molecule (QTAIM) provided the evidence of dominating dispersion energy in stabilizing the resultant complexes. The HOMO-LUMO energies, NBO charge transfer and UV-vis analysis justify the higher electronic transition in UA1@GDY, plays a role of higher sensitivity of GDY towards the π-stacked geometries over all other possible interaction orientations. The present findings bestow the higher sensitivity of GDY towards uric acid via π-stacking interactions.

show abstract

Detection of Purine Metabolite Uric Acid with Picolinic-Acid-Functionalized Metal–Organic Frameworks

Cited by 71 publications

References 58 publications

Metal–Organic Frameworks for Biomedical Applications

Metal–Organic Frameworks for Biomedical Applications

A Comparison of Uric Acid Optical Detection Using as Sensitive Materials an Amino-Substituted Porphyrin and Its Nanomaterials with CuNPs, PtNPs and Pt@CuNPs

Electrochemical Sensing Behavior of Graphdiyne Nanoflake Toward Uric Acid; A Quantum Chemical Approach

Contact Info

Product

Resources

About