“…DMT, bufotenine and 5-MeODMT have been detected in higher levels in blood and urine samples from cases of acute schizophrenia than in samples from non-schizophrenics or chronic schizophrenics (Fischer & Spatz, 1970;Tanimukai, Ginther, Spaide, Bueno & Himwich, 1970; Narasimhachari, Heller, Spaide, Haskovec, Fujimori, Tabushi & Himwich, 1971;Narasimhachari, Heller, Spaide, Haskovec, Meltzer, Strahilevitz & Himwich, 1971). An enzyme capable of synthesizing N,N-dimethylated tryptamines from tryptamine or 5-HT has been demonstrated in rat brain and in human brain (Mandell, Buckingham & Segal, 1971;Saavedra & Axelrod, 1972); the O-methylation of 5-hydroxytryptamine in the pineal body is well known (Axelrod & Weissbach, 1961), and recently, Green, Koslow & Costa (1973) demonstrated the presence in rat hypothalamus of 5-MeOT, apparently originating outside the pineal, since pinealectomy had little effect on the brain concentrations.…”