Detection of polymorphisms in the promoters of matrix metalloproteinases 2 and 9 genes in breast cancer in South Brazil: preliminary results

Roehe, Adriana Vial; Frazzon, Ana Paula Guedes; Agnes, Grasiela; Damin, Andréa Pires Souto; Hartman, Antonio A; Graudenz, Marcia S

doi:10.1007/s10549-006-9273-1

Cited by 39 publications

(41 citation statements)

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“…Notably, the -1306 T-allele frequency differs across ethnicities: Saudi (0.10), Chinese (0.12), Brazilian (0.18), Greek (0.18), Australian (0.24), Polish (0.24), Mexican (0.26), Swedish (0.26) (Grieu et al 2004;Zhou et al 2004;Lei et al 2007;Roehe et al 2007;Delgado-Enciso et al 2008;Beeghly-Fadiel et al 2009;Ledwoń et al 2013;Saeed et al 2013a;Zagouri et al 2013). However, when subgroup analysis by ethnicity was performed, we could only find that CC was associated with a significant increase in breast susceptibility among Latin-Americans in the dominant model and the association disappeared in other models.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 9 case-control studies were eligible Lei et al 2007;Roehe et al 2007;DelgadoEnciso et al 2008;Beeghly-Fadiel et al 2009;Ledwoń et al 2013;Saeed et al 2013a;Slattery et al 2013;Zagouri et al 2013). The flow chart of study selection is shown in Figure 1.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…The total number of sample size of each study ranged from 182 to 7775. For ethnicity distribution, there were 3 studies of Europeans (Lei et al 2007;Ledwoń et al 2013;Zagouri et al 2013), 2 studies of East Asians Beeghly-Fadiel et al 2009), 2 studies of Latin-Americans (Roehe et al 2007;Delgado-Enciso et al 2008), 1 study of Arabians (Saeed et al 2013a) and 1 study of mixed people (Slattery et al 2013). All the studies were reported in full text.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Lack of Association Between the Matrix Metalloproteinase-2 -1306C>T Polymorphism and Breast Cancer Susceptibility: a Meta-analysis

Yang¹,

Wang

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Lack of Association Between the Matrix Metalloproteinase-2 -1306C>T Polymorphism and Breast Cancer Susceptibility: a Meta-analysis

Yang¹,

Wang

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…A study in Chinese population showed that the -1306 CC genotype to double breast cancer probability (Zhou et al, 2004). Contrarily, Roehe et al (2007) reported that, no association between -1306 C>T polymorphism and breast cancer. Studies in a Swedish population reported that, no association was found between the MMP-2 promoter polymorphisms and CRC (Elander et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Matrix Metalloproteinase-2 (-1306 C>T) Promoter Polymorphism and Risk of Colorectal Cancer in the Saudi Population

Saeed

Alanazi²,

Parine³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity against matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism (SNP) at -1306, which disrupts a Sp1-type promoter site (CCACC box), results in strikingly lower promoter activity with the T allele. In the present study, we investigated whether this MMP-2 genetic polymorphism might be associated with susceptibility to colorectal cancer (CRC) in the Saudi population. We also analyzed MMP-2 gene expression level sin CRC patients and 4 different cancer cell lines. Materials and Methods: TaqMan allele discrimination assays and DNA sequencing techniques were used to investigate the C -1306 T SNP in the MMP-2 gene of Saudi colorectal cancer patients and controls. The MMP-2 gene expression level was also determined in 12 colon cancer tissue samples collected from unrelated patients and histologically normal tissues distant from tumor margins. Results and Conclusions: The MMP-2 C -1306 T SNP in the promoter region was associated with CRC in our Saudi population and the MMP-2 gene expression level was found to be 10 times higher in CRC patients. The MMP-2 C -1306 T SNP is significantly associated with CRC in the Saudi population and this finding suggested that MMP-2 variants might help predict CRC progression risk among Saudis. We propose that analysis of this gene polymorphism could assist in identification of patient subgroups at risk of a poor disease outcome.

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“…Lei et al studies show no effect of genotype on the increased risk of breast cancer and subsequent prognosis of survival for the T/T genotype [30]. Roehe and colleagues who have examined this polymorphism, in turn, report no dependence between the risk and clinicopathological features of breast cancer [41]. Beeghly-Fadiel and colleagues also studied other SNPs for MMP-9 gene, but their results do not indicate a relationship with the risk of breast cancer [52].…”

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confidence: 97%

Genetic polymorphism of matrix metalloproteinases in breast cancer

Wieczorek¹,

Reszka²,

Gromadzińska³

et al. 2012

neo

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The family of human matrix metalloproteinases (MMPs) consists of 24 zinc-and calcium-dependent proteolytic enzymes. MMPs are divided into six subgroups, in terms of differences in the substrate specificity with structural domain architecture. These enzymes are involved in many physiological processes, such as skeletal development, wound healing, scar formation, as well as carcinogenesis. MMPs, fulfilling its function of degradation of extracellular matrix components, are involved in one of the stages of angiogenesis enabling the development, growth and spread of the primary tumor. Therefore, the search for the common polymorphic variants of MMPs, new genetic markers as prognostic factors in breast cancer progress seems to be understandable.The minireview presents the results of 19 case-control or prospective studies concerning the association of SNPs of genes encoding nine MMPs: MMP-1, -2, -3, -7, -8, -9, -12, -13, -21 with the breast cancer risk, progression and survival. Key words: matrix metalloproteinases, genetic polymorphism, breast cancerBreast cancer, one of the leading civilization diseases, has for a number of years already focused attention of clinicians and researchers. It is the most commonly diagnosed cancer in women and is the major cause of death among female cancer patients. GLOBCAN estimates that, among the 12.7 million cancer cases worldwide in 2008, 2.9 million were women with breast cancer, and a million died of this cancer [1]. It is estimated that approximately 10% of the incidence of breast cancer is genetically-related and in most of the cases results from mutations in the genes BRCA1, BRCA2, p53, ATM. Attention should also be paid to a number of environmental factors related to diet and occupational exposure, including tobacco smoking, alcohol intake, obesity, shift work at night. Factors considered in the etiology of breast cancer include also endogenous hormonal factors, such as age of occurrence of menarche, menopause, number of births, and exogenous hormonal factors such as use of hormonal contraceptives or hormonal replacement [2,3]. Currently, a description of cancer cases includes clinical stage and Tumor Nodus Metastases (TNM) clinical classification, hormone receptor status and BRCA1, BRCA2 mutations. All these indicators are still not sufficient to predict the course of the cancer and, therefore, it is important to search for new markers that will enable the patient's prognosis and new predictive markers of cancer risk. As the majority of breast cancer deaths are caused by the invasion of cancer to other, sometimes distant organs, it is believed that it is appropriate to study the role of the enzyme gene polymorphisms that affect the process of angiogenesis largely responsible for the development, growth and metastatic capacity of the primary tumor. Key enzymes involved in these processes include the matrix metalloproteinases (MMPs) participating in an important stage of angiogenesis, namely the degradation of extracellular matrix (ECM) components.Matrix metalloproteinases. MM...

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Detection of polymorphisms in the promoters of matrix metalloproteinases 2 and 9 genes in breast cancer in South Brazil: preliminary results

Cited by 39 publications

References 3 publications

Lack of Association Between the Matrix Metalloproteinase-2 -1306C>T Polymorphism and Breast Cancer Susceptibility: a Meta-analysis

Lack of Association Between the Matrix Metalloproteinase-2 -1306C>T Polymorphism and Breast Cancer Susceptibility: a Meta-analysis

Matrix Metalloproteinase-2 (-1306 C>T) Promoter Polymorphism and Risk of Colorectal Cancer in the Saudi Population

Genetic polymorphism of matrix metalloproteinases in breast cancer

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