Detection of Newly Described Astrovirus MLB1 in Stool Samples from Children

Bányai, Krisztiàn; Meleg, Edina; Moschidou, P.; Martella, Vito

doi:10.3201/eid1601.091120

Cited by 17 publications

(13 citation statements)

References 5 publications

(13 reference statements)

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“…Interspecies transmission of AstV has been documented on more occasions (De Battisti et al., ; De Benedictis, Schultz‐Cherry, Burnham, & Cattoli, ; Mihalov‐Kovacs et al., ; Nagai et al., ). Also, novel human AstVs (MLB1, MLB2, VA1, HMO‐C, HMO‐B, HMO‐A, VA‐2) have been identified that are genetically unrelated to “classical” human AstVs (Banyai, Meleg, Moschidou, & Martella, ; Finkbeiner, Holtz, et al., ; Finkbeiner, Le, Holtz, Storch, & Wang, ; Finkbeiner, Li, et al., ; Kapoor et al., ) and closer to animal AstVs. The origin of animal‐like human AstVs has not been deciphered yet.…”

Section: Discussionmentioning

confidence: 99%

Detection and phylogenetic characterization of astroviruses in insectivorous bats from Central‐Southern Italy

Amoroso

Russo

Lanave

et al. 2018

Zoonoses and Public Health

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In recent years, bats have been found to harbour many viruses, raising several questions about their role as reservoirs and potential disseminators of zoonotic viruses. We investigated the presence of six virus families in bats in three regions of Central-Southern Italy. Astroviruses were identified in seven of 13 bat species. Sequence analysis revealed marked genetic heterogeneity among the astroviruses identified, with nucleotide identity ranging between 60.26% and 87.62%. Astrovirus diversity was not associated with the bat species, the geographic areas or the bat colony, suggesting the circulation of several astrovirus strains in Italian ecosystems. Genetic diversification and interspecies transmission appear common in bat astroviruses and could provide, potentially, the bases for transmission to humans and other mammals. Yet overemphasizing this risk might have detrimental consequences for bat conservation and preservation of the important ecosystem services bats provide.

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Section: Discussionmentioning

confidence: 99%

Detection and phylogenetic characterization of astroviruses in insectivorous bats from Central‐Southern Italy

Amoroso

Russo

Lanave

et al. 2018

Zoonoses and Public Health

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“…AstV-MLB1 is not yet a well-established AD agent and its role in human health remains unknown. A recent control case study conducted in India could not determine the association between AstV-MLB1 and AD [ 43 ]. Another important point is the fact that a large number of samples remain without an etiologic agent, drawing attention to other pathogens that may be involved.…”

Section: Discussionmentioning

confidence: 99%

Surveillance of Human Astrovirus Infection in Brazil: The First Report of MLB1 Astrovirus

et al. 2015

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Human astrovirus (HAstV) represents the third most common virus associated with acute diarrhea (AD). This study aimed to estimate the prevalence of HAstV infection in Brazilian children under 5 years of age with AD, investigate the presence of recently described HAstV strains, through extensive laboratory-based surveillance of enteric viral agents in three Brazilian coastal regions between 2005 and 2011. Using reverse transcription-polymerase chain reaction (RT-PCR), the overall HAstV detection rate reached 7.1% (207/2.913) with percentage varying according to the geographic region: 3.9% (36/921) in the northeast, 7.9% in the south (71/903) and 9.2% in the southeast (100/1.089) (p < 0.001). HAstV were detected in cases of all age groups. Detection rates were slightly higher during the spring. Nucleotide sequence analysis of a 320-bp ORF2 fragment revealed that HAstV-1 was the predominant genotype throughout the seven years of the study. The novel AstV-MLB1 was detected in two children with AD from a subset of 200 samples tested, demonstrating the circulation of this virus both the in northeastern and southeastern regions of Brazil. These results provide additional epidemiological and molecular data on HAstV circulation in three Brazilian coastal regions, highlighting its potential to cause infantile AD.

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“…These novel human AstVs are distantly related to "classic" human AstV types 1 to 8, and more similar genetically to some animal AstVs. [23][24][25] Antibodies to one such novel AstV, strain MAstV/GII.B/Hu/THA/2001/NE-3010, have been detected in 20% to 36% of the sera of children. 26 These findings suggest recent interspecies transmission events of AstVs from animals to humans and, more importantly, widespread exposure of humans to these viruses.…”

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confidence: 99%