Detection of New Babesia microti-like Parasites in a Rhesus Monkey (Macaca mulatta) with a Suppressed Plasmodium cynomolgi Infection

Wel, Annemarie Voorberg-v.d.; Kocken, Clemens H. M.; Zeeman, Anne‐Marie; Thomas, Alan W.

doi:10.4269/ajtmh.2008.78.643

Cited by 13 publications

(8 citation statements)

References 14 publications

(17 reference statements)

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“…Similar co-infection with both agents were reported from experiments using animal models of malaria, the rhesus monkey imported from Guangxi, P.R. China with a suspected infection of B. microti -like that originated from a primate-breeding facility [ 22 ]. Two cases of febrile patients who were co-infected with Plasmodium and Babesia in malaria endemic areas were detected in our laboratory using molecular epidemiology survey, but the dominant parasite was unclear and to detect species of Plasmodium or Babesia by microscopy in co-infection cases was more difficult [ 16 ].…”

Section: Reviewsupporting

confidence: 68%

“…This indicates that B. microti- infections were not the predominant species in Xinjiang Uygur Autonomous Region [ 43 ]. In 2008, B. microti -like parasites were identified in one rhesus monkey ( Macaca mulatta ) imported from Guangxi Zhuang Autonomous Region and the suspected infection of B. microti originated from a primate-breeding facility [ 22 ]. This provided anecdoctal evidence of the presence of natural foci of B. mciroti in Guangxi Zhuang Autonomous Region.…”

Section: Reviewmentioning

confidence: 99%

“…A et al . [ 22 ] Henan Xinyang N/A Rattus norvegicus 9.1 (1/11) No Zhao X et al . [ 44 ] Zhejiang Hangzhou N/A R. tanezumi, R.norvegcus 2.8 (3/106) Yes Jiang LP et al .…”

Section: Reviewmentioning

confidence: 99%

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Human babesiosis, an emerging tick-borne disease in the People’s Republic of China

Zhou

Shang²,

Huang

et al. 2014

Parasites Vectors

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Babesiosis is a typical zoonotic, emerging disease caused by a tick-borne intraerythrocytic protozoan of Babesia spp. that also can be transmitted by blood transfusion. Babesiosis imposes an increasing public-health threat. We reviewed and mapped epidemiological studies on Babesia in vectors and/or rodents in the People’s Republic of China (P.R. China) and found that B. microti was the predominant species detected in the investigated regions such as Heilongjiang, Zhejiang, Fujian provinces and Taiwan island. We reviewed a series of sporadic human babesiosis cases collected from 1940’s to 2013, in Yunnan, Inner Mongolia, Taiwan and Zhejiang and other regions including a main endemic area of malaria on the China-Myanmar border areas in P.R. China. Clinical manifestations of human babesiosis were also reviewed. Human babesiosis may have previously been overlooked in P.R. China due to a lack of medical awareness and the limitation of clinical diagnostic methods.Electronic supplementary materialThe online version of this article (doi:10.1186/s13071-014-0509-3) contains supplementary material, which is available to authorized users.

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Section: Reviewsupporting

confidence: 68%

Section: Reviewmentioning

confidence: 99%

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Human babesiosis, an emerging tick-borne disease in the People’s Republic of China

Zhou

Shang²,

Huang

et al. 2014

Parasites Vectors

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“…Co-infection with both agents was reported in another rhesus monkey imported from Guangxi, P.R. China and the suspected infection of B. microti -like originated from primate-breeding facility [34]. Here, we detected two cases of febrile patients who were co-infected with Plasmodium spp.…”

Section: Discussionmentioning

confidence: 74%

Co-infections with Babesia microti and Plasmodium parasites along the China-Myanmar border

Zhou

Chen

et al. 2013

Infect Dis Poverty

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BackgroundBabesiosis is an emerging health risk in several parts of the world. However, little is known about the prevalence of Babesia in malaria-endemic countries. The area along the China-Myanmar border in Yunnan is a main endemic area of malaria in P.R. China, however, human infection with Babesia microti (B. microti) is not recognized in this region, and its profile of co-infection is not yet clear.MethodsTo understand its profile of co-infections with B. microti, our investigation was undertaken in the malaria-endemic area along the China-Myanmar border in Yunnan between April 2012 and June 2013. Four parasite species, including B. microti, Plasmodium falciparum (P. falciparum), P. vivax, and P. malariae, were identified among 449 suspected febrile persons detected by nested polymerase chain reaction (PCR) assay based on small subunit ribosomal ribonucleic acid (RNA) genes of B. microti and Plasmodium spp.ResultsOf all the collected samples from febrile patients, mono-infection with B. microti, P. vivax, P. falciparum, and P. malariae accounted for 1.8% (8/449), 9.8% (44/449), 2.9% (13/449), and 0.2% (1/449), respectively. The rate of mixed infections of B. microti with P. falciparum or P. vivax are both 0.2% (1/449), and mixed infections of P. falciparum and P. vivax accounted for 1.1% (5/449).ConclusionsThis report supports the hypothesis that babesiosis caused by B. microti is emerging along the China-Myanmar border in the Yunnan province, P.R. China, but it was ignored because of low parasitemia or mixed infection with Plasmodium spp. More sensitive and specific diagnosis methods are needed to find the rapid response mechanism of emergency for babesiosis and malaria co-prevalence areas.

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“…During recovery from anemia, the parasitemia decreased to less than 5%. The piroplasm was identified by PCR and subsequent 18S ribosomal RNA gene sequencing [3] as a rhesus monkey B. microti -like parasite [7], showing 100% identity to Genbank Accession No. EU168705.1.…”

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confidence: 99%

Persistent babesiosis in a Rhesus macaque (Macaca mulatta) infected with a simian–human immunodeficiency virus

Zlobec

Gill

Holman

et al. 2014

J of Medical Primatology

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Detection of New Babesia microti-like Parasites in a Rhesus Monkey (Macaca mulatta) with a Suppressed Plasmodium cynomolgi Infection

Cited by 13 publications

References 14 publications

Human babesiosis, an emerging tick-borne disease in the People’s Republic of China

Human babesiosis, an emerging tick-borne disease in the People’s Republic of China

Co-infections with Babesia microti and Plasmodium parasites along the China-Myanmar border

Persistent babesiosis in a Rhesus macaque (Macaca mulatta) infected with a simian–human immunodeficiency virus

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