Detection of Mucosal Human Papillomavirus Types 6/11 in Cutaneous Lesions from Transplant Recipients

Soler, C; Chardonnet, Y; Allibert, P.; Euvrard, Sylvie; Schmitt, Daniel; Mandrand, Bernard

doi:10.1111/1523-1747.ep12365211

Cited by 54 publications

(37 citation statements)

References 22 publications

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“…Concerning the type of virus, HPV 16/18 is detected with the same percentage in the two groups of patients (41% in immunocompetent and 42% in immunosuppressed patients), HPV 6/11 is detected in only 11% of immunocompetent patients as compared to 37% of immunosuppressed patients. This last result is in agreement with reports of the literature showing a high rate of this type of mucous HPV (ordinarily non-oncogenic) in tumours of transplanted patients [44, 46]. We did not find any study in the literature comparing the rates of HPV detection specifically in BD for immunocompetent and immunosuppressed patients.…”

Section: Discussionsupporting

confidence: 93%

“…Thus, in kidney or heart transplant patients, HPV has been found in skin tumours, with a great variety of types [1, 2, 4, 5, 6, 11, 16, 18, 31, 33], often with viral co-infections (cytomegalovirus, herpes simplex virus, etc.) in many cases [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 41, 43, 44, 45, 46, 47]. Several studies have reported a high prevalence of HPV DNA in transplant squamous cell carcinoma ranging from 69 to 91% [1, 2, 3, 7, 9, 11, 41].…”

Section: Discussionmentioning

confidence: 99%

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Human Papillomavirus and Extragenital in situ Carcinoma

Quéreux

Nguyen

Dréno³

2004

Dermatology

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Background: The relation between human papillomavirus (HPV) and extragenital Bowen’s disease (BD) is controversial. Methods: This study used in situ hybridisation to evaluate the rate of HPV in extragenital cutaneous BD and investigated possible relations with immune status and exposure of skin to light. Results: HPV DNA was detected in 58% of 69 samples from 50 patients. The percentage of HPV detection was not significantly higher in exposed (55%) than unexposed areas (65%), and no difference in HPV rate was found between immunosuppressed and immunocompetent patients. Conclusion: Thus, this study confirms the high rate of HPV detection in extragenital cutaneous BD and suggests that there is no apparent relation concerning exposed areas and immune status.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus and Extragenital in situ Carcinoma

Quéreux

Nguyen

Dréno³

2004

Dermatology

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“…However, in agreement with the findings of other studies [10, 12, 13], HPV-16 seems to be present in only a small number of cutaneous SCCs and is therefore not generally involved in SCC development. There are a few reports on the presence of HPV-6 and HPV-11 in SCC samples [12, 13, 28]. HPV-6 was also detected in basal-cell carcinoma and keratoacanthoma lesions [11, 14], but, similarly to HPV-16, in all studies only a small number of specimens was positive.…”

Section: Discussionmentioning

confidence: 95%

Frequency and Spectrum of HPV Types Detected in Cutaneous Squamous-Cell Carcinomas Depend on the HPV Detection System: A Comparison of Four PCR Assays

et al. 2000

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Background: The association of human papillomavirus (HPV) with cutaneous squamous-cell carcinomas (SCCs) has been described recently, but the frequency and spectrum of HPV types identified differed substantially in distinct studies. Objective: Comparison of different PCR assays with respect to sensitivity and range of HPV types detected. Method: Cutaneous SCC were analyzed for HPV DNA using both consensus PCR assays with degenerate primers and PCR assays with nondegenerate primers derived from HPV types 5 and 8. Results: HPV DNA was found in 50% of SCC specimens using degenerate primers. The rate of HPV-DNA-positive specimens increased to 69% when PCR assays with nondegenerate primers were applied in addition. The spectrum of HPV types detected with each of the PCR assays differed considerably. Conclusions: The frequency and spectrum of HPV types detected in cutaneous SCC strongly depends on the HPV detection system used and urges the need for standardization of HPV detection and typing in skin lesions in order to characterize HPV types predominating in distinct tumors.

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“…The presence of HPV 6/11 in benign or malignant skin lesions of transplant patients has been reported only rarely [28]. HPV 6 [3], 11 [7], and both types together [28] have also been noted in malignant skin lesions of nonimniunosuppressed subjects.…”

Section: Discussionmentioning

confidence: 99%

“…HPV 6 [3], 11 [7], and both types together [28] have also been noted in malignant skin lesions of nonimniunosuppressed subjects. It is noteworthy that, in our study, HPV 6/11 was not found in any benign lesion in the control population.…”

Section: Discussionmentioning

confidence: 99%

Frequency of mucosal HPV DNA detection (types 6/11, 16/18, 31/35/51) in skin lesions of renal transplant patients

Mansat-Krzyzanowska¹,

Dantal

Hourmant

et al. 1997

Transplant Int

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Human papillomaviruses (HPV) probably play a role in the development of skin cancer in renal transplant recipients. Since some mucosal HPV are strongly related to cervical cancer, we compared the frequency of HPV DNA detection (mucosal types 6/1 I , 16/18, and 31/ 33/51) in skin cancer of renal transplant recipients (21 lesions) with that in normal subjects without immunodeficiency (21 lesions) and studied the frequency of these same HPV in benign lesions of renal transplant recipients (34 lesions) and normal subjects (30 lesions). An in situ hybridization technique employing cold biotin probes was used. HPV DNA was not significantly ( P = 0.09.5) more frequent in malignant skin cancer in renal transplant recipients (42.9 %) than in normal subjects (19.04 %), but was significantly more frequent in benign lesions in renal transplant recipients (32.4 YO) than in controls (10 YO; P < 0.0.5). These results on a limited number of skin lesions do not allow one to confirm the predominant role of mucosal HPV in the development of skin cancer in renal transplant recipients. HPV interaction with other factors related to the immunosuppressive state may play a role.

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Detection of Mucosal Human Papillomavirus Types 6/11 in Cutaneous Lesions from Transplant Recipients

Cited by 54 publications

References 22 publications

Human Papillomavirus and Extragenital in situ Carcinoma

Human Papillomavirus and Extragenital in situ Carcinoma

Frequency and Spectrum of HPV Types Detected in Cutaneous Squamous-Cell Carcinomas Depend on the HPV Detection System: A Comparison of Four PCR Assays

Frequency of mucosal HPV DNA detection (types 6/11, 16/18, 31/35/51) in skin lesions of renal transplant patients

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