Detection of &lt;i&gt;Chlamydia pneumoniae&lt;/i&gt; DNA in the Coronary Arteries and Bypass in Three Patients with Diffuse Coronary Artery Disease

Zorc, Marjeta; Vraspir-Porenta, Olga; Keše, Darja; Petrovič, Danijel; Legan, Mateja

doi:10.1159/000083436

Cited by 2 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is supported by the work of Bartels et al, who observed a strong correlation between elevated Cpn IgG titers and the detection of Cpn in occluded vein grafts [ 11 ]. Similar data were shown by Zorc et al, implicating a possible relationship between Cpn presence and occluded arterial bypass grafts [ 12 ]. These studies suggest that Cpn is present in occluded grafts, however, experimental evidence for this is currently lacking.…”

Section: Introductionsupporting

confidence: 88%

“…Cpn is an obligatory intracellular Gram-negative bacterium that was first isolated as a respiratory pathogen. This micro-organism has also been isolated from coronary arteries of patients with acute coronary syndrome [ 12 ], as well as from carotid arteries [ 19 ], the aorta and peripheral arteries [ 20 ]. These observations in combination with multiple in vitro findings [ 7 ] demonstrating a stimulating effect of Cpn on SMC proliferation, supported a role for Cpn in obstructive vascular disease.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Chlamydia pneumoniae aggravates vein graft intimal hyperplasia in a rat model

et al. 2007

View full text Add to dashboard Cite

Background: Along with angioplasty, autologus vein grafts are commonly used for artery bypass grafting in patients with advanced arterial stenosis and drug-resistant angina pectoris. Although initially a successful procedure, long-term functionality is limited due to proliferation and migration of smooth muscle cells. Like in atherosclerosis, common chronic infections caused by viruses and bacteria may contribute to this process of vein graft failure. Here we investigated the possible role of Chlamydia pneumoniae (Cpn) in the pathogenesis of venous graft failure in an experimental animal model. In 2 groups (n = 10 rats/group), an epigastric vein-to-common femoral artery interposition graft was placed. Immediately thereafter, rats were infected with Cpn (5*10 8 IFU) or injected with control solutions. Rats were sacrificed three weeks after surgery and the grafts were harvested for morphometrical and immunohistochemical analysis.

show abstract

Section: Introductionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Chlamydia pneumoniae aggravates vein graft intimal hyperplasia in a rat model

et al. 2007

View full text Add to dashboard Cite

show abstract

“…This is supported by the work of Bartels et al, who observed a strong correlation between elevated C. pneumoniae IgG titers and the detection of C. pneumoniae in occluded vein grafts . Similar data were shown by Zorc et al, implicating a possible relationship between C. pneumoniae presence and occluded arterial bypass grafts (Zorc 2005). These studies suggest that C. pneumoniae is present in occluded grafts, however, experimental evidence for this is currently lacking.…”

Section: Most Compelling Evidence Comes From Data Concerning the Intracellular Pathogensupporting

confidence: 80%

“…pneumoniae in occluded vein grafts . Similar data were shown by Zorc et al, suggesting an etiological role for C. pneumoniae in arterial bypass failure (Zorc 2005 Although presence of C. pneumoniae antibodies in patients with venous bypass failure has been reported in literature, again no experimental studies have been published yet shedding light on a possible causal relationship. One could however speculate that mechanisms resembling those previously discussed in the interplay between C. pneumoniae and restenosis may play a similar role in venous bypass failure.…”

Section: Chlamydia Pneumoniae and Venous Bypass Failuresupporting

confidence: 79%

“…pneumoniae is an obligatory intracellular Gram-negative bacterium that was first isolated as a respiratory pathogen. This micro-organism has also been isolated from coronary arteries of patients with acute coronary syndrome (Zorc 2005), as well as from carotid arteries (Johnston 2005), the aorta and peripheral arteries (Gutierrez 2001). These observations in combination with multiple in vitro findings ) demonstrating a stimulating effect of C. pneumoniae on SMC proliferation, supported a role for C. pneumoniae in obstructive vascular disease.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Role of infections on intimal hyperplasia : focus on Cytomegalovirus and Chlamydia pneumoniae

Kloppenburg¹

View full text Add to dashboard Cite

People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal.If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the "Taverne" license above, please follow below link for the End User Agreement:

show abstract

Detection of <i>Chlamydia pneumoniae</i> DNA in the Coronary Arteries and Bypass in Three Patients with Diffuse Coronary Artery Disease

Cited by 2 publications

References 9 publications

Chlamydia pneumoniae aggravates vein graft intimal hyperplasia in a rat model

Chlamydia pneumoniae aggravates vein graft intimal hyperplasia in a rat model

Role of infections on intimal hyperplasia : focus on Cytomegalovirus and Chlamydia pneumoniae

Contact Info

Product

Resources

About