Detection of IgE anti-parvovirus B19 and increased CD23+ B cells in parvovirus B19 infection: relation to Th2 cytokines

Bluth, Martin H.; Norowitz, Kevin B.; Chice, Seto; Shah, V.; Nowakowski, Maja; Josephson, Alan S.; Durkin, Helen G.; Smith‐Norowitz, Tamar A.

doi:10.1016/s1521-6616(03)00098-6

Cited by 21 publications

(29 citation statements)

References 37 publications

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“…Thus, this report may suggest a possible mechanism to explain the prolonged duration of protective immunity against parvovirus reinfection in the human population. Previous studies in our laboratory were the first to demonstrate the presence of IgE anti-parvovirus B19 antibodies 7 months after infection in a nonimmunodeficient patient [5]. The fact that this study demonstrates the presence and persistence of IgE anti-parvovirus B19 antibodies as late as 3 years after presentation of symptoms and in both healthy and immunodeficient patients elucidates a unique characteristic of IgE biology.…”

Section: Discussionsupporting

confidence: 61%

“…Previous studies in our laboratory were the first to demonstrate that IgE anti-parvovirus B19 is produced by a parvovirus B19 -infected child [5]. The presence of virus-specific IgE has been demonstrated in several viral infections.…”

Section: Discussionmentioning

confidence: 91%

“…IgE. The presence of IgE anti-parvovirus B19 antibodies was determined as previously described [5]. Briefly, parvovirus B19 Western blot strips (Mikrogen, Martinsried, Germany) were incubated with sera diluted 1:100 in washing/diluting buffer (Tris-buffered saline, NaCl, Tween-20, 0.01% methylisothiazolone [Mikrogen], 0.1% oxypyrion, protein [Mikrogen]) on a shaker for 20 hours at room temperature.…”

Section: Detection Of Parvovirus B19 Antibodies In Serummentioning

confidence: 99%

“…Total cellular RNA (2 g/mL) was extracted from PBMC by polymerase chain reaction (PCR) as previously described [5] with TriZol reagent (Gibco/BRL), according to manufacturer's recommendation. Pellets were dissolved in TE buffer (10 mM Tris HCl (Sigma Chemical Company, St. Louis, MO, USA), pH 7.5, 1 mM EDTA, Sigma), and stored at Ϫ70°C in a Bio-Freezer (Forma Scientific, Marietta, OH, USA).…”

Section: Detection Of Cytokine-specific and Epsilon-specific Mrnamentioning

confidence: 99%

“…IgE anti-human immunodeficiency virus type 1 (HIV-1) [2][3][4], parvovirus B19 [5], parainfluenza [6], and respiratory syncytial virus [7,8] have been described. Studies in our laboratory were the first to describe a functional role for IgE anti-HIV-1 in that IgE anti HIV-1 antibodies strongly suppress virus replication in vitro [3], and possibly may contribute to nonprogressor status.…”

Section: Introductionmentioning

confidence: 99%

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IgE, CD8+CD60+ T Cells and IFN-α in Human Immunity to Parvovirus B19 in Selective IgA Deficiency

et al. 2005

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 91%

Section: Detection Of Parvovirus B19 Antibodies In Serummentioning

confidence: 99%

Section: Detection Of Cytokine-specific and Epsilon-specific Mrnamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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IgE, CD8+CD60+ T Cells and IFN-α in Human Immunity to Parvovirus B19 in Selective IgA Deficiency

et al. 2005

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A review of blood diseases and cytopenias associated with human parvovirus B19 infection

Kerr

2015

Reviews in Medical Virology

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Parvovirus B19 is a single-stranded DNA virus which preferentially targets the erythroblast resulting in red cell aplasia, which is temporary in immunocompetent persons. Since the discovery of B19 virus in 1975, a wide variety of blood diseases and cytopenias affecting several blood cell lineages have been documented during or following B19 infection. These include cytopenias affecting the erythroid, megakaryoblastoid, myeloid and lymphoid lineages, as well as a variety of bicytopenias, pancytopenia, bone marrow necrosis / fat embolism syndrome, myelodysplastic syndrome, leucoerythroblastopenia, and hemophagocytic lymphohistiocytosis. B19 infection may also complicate and precede the course of acute leukemia, the significance of which remains to be determined. This review describes the current state of knowledge of the abnormalities of individual blood cell lineages encountered during parvovirus B19 infection, over the almost 40 years since its discovery, and reveals some very interesting themes, which improve our understanding of the pathogenesis of B19 infection with particular reference to the bone marrow.

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Increased seroprevalence of Enterovirus 71 IgE antibodies in asthmatic compared with non-asthmatic children

et al. 2016

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Detection of IgE anti-parvovirus B19 and increased CD23+ B cells in parvovirus B19 infection: relation to Th2 cytokines

Cited by 21 publications

References 37 publications

IgE, CD8+CD60+ T Cells and IFN-α in Human Immunity to Parvovirus B19 in Selective IgA Deficiency

IgE, CD8+CD60+ T Cells and IFN-α in Human Immunity to Parvovirus B19 in Selective IgA Deficiency

A review of blood diseases and cytopenias associated with human parvovirus B19 infection

Increased seroprevalence of Enterovirus 71 IgE antibodies in asthmatic compared with non-asthmatic children

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