IgE, CD8+CD60+ T Cells and IFN-α in Human Immunity to Parvovirus B19 in Selective IgA Deficiency

Bluth, Martin H.; Norowitz, Kevin B.; Chice, Seto; Shah, V.; Nowakowski, Maja; Durkin, Helen G.; Smith‐Norowitz, Tamar A.

doi:10.1016/j.humimm.2005.07.009

Cited by 10 publications

(19 citation statements)

References 45 publications

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“…Immunoglobulin (Ig) E is involved in non‐atopic diseases and may play an important role in immunity to viruses, as well as to specific spirochetes. Previous studies in our laboratory were the first to demonstrate the existence of IgE anti‐parvovirus B19 in serum of a parvovirus B19‐infected child, and its persistence in serum 7 months post‐infection [1], as well as in IgA deficiency [2]. Earlier studies in our laboratory were the first to identify the presence and function of IgE anti‐HIV in serum of a subset of HIV‐1 seropositive, non‐progressor paediatric patients [3, 4], and that specific IgE anti‐HIV‐1 antibodies (Abs) may protect against HIV‐1 disease progression by suppressing virus production [3–5].…”

Section: Introductionmentioning

confidence: 99%

IgE Anti‐Borrelia burgdorferi Components (p18, p31, p34, p41, p45, p60) and Increased Blood CD8⁺CD60⁺ T Cells in Children with Lyme Disease

et al. 2007

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Immunoglobulin (Ig) E may provide immunity against Borrelia burgdorferi infection (Lyme disease) in children which lasts throughout adulthood. We investigated the presence and persistence of IgE anti‐B. burgdorferi antibodies (Abs) in paediatric patients infected with Lyme disease over time. Serum immunoglobulin levels, presence of IgG and IgE anti‐B. burgdorferi components, and distributions of blood T, B and natural killer lymphocyte subsets were studied in B. burgdorferi‐infected and ‐uninfected children (nephelometry, UniCAP Total IgE Fluoroenzymeimmunoassay, Western blot, flow cytometry). Total serum IgM, IgG, IgE and IgA levels, and distributions of blood lymphocytes (CD4+, CD8+, CD19+) of both groups, excluding CD8+CD60+ T cells, were within normal ranges. However, infected, but not uninfected children made IgG anti‐B. burgdorferi proteins p18, p31, p34, p41, p45, but not IgG anti‐p60, and IgE anti‐B. burgdorferi proteins p31, p34, p41, p45, p60, but not IgE anti‐p18. These proteins were also detected in an infected child 1 year post‐infection. Interestingly, CD8+CD60+ T‐cell numbers were significantly increased (fourfold) in infected, compared with uninfected, patients (P = 0.001). These results demonstrate that specific IgE anti‐B. burgdorferi Abs are generated and persist in children with Lyme disease and that CD8+CD60+ T cells may play an important role in these responses.

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Section: Introductionmentioning

confidence: 99%

IgE Anti‐Borrelia burgdorferi Components (p18, p31, p34, p41, p45, p60) and Increased Blood CD8⁺CD60⁺ T Cells in Children with Lyme Disease

et al. 2007

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“…Furthermore, the existence of individuals with HIV and hyper‐IgE serum indicates that IgE can confer protection against HIV replication . The importance of IgE has also been documented in parvovirus B19 infection . While it is possible that the presence of IgE against DENV in the sera of individuals with SLE could have contributed to the virus neutralization effects, especially in sera with low IgG titers, we did not investigate this because of limitations in availability of serum samples.…”

Section: Discussionmentioning

confidence: 99%

Sera of patients with systemic lupus erythematosus cross‐neutralizes dengue viruses

Zainal

Tan

Johari

et al. 2018

Microbiology and Immunology

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Dengue is the most prevalent mosquito‐borne disease in Southeast Asia, where the incidence of systemic lupus erythematosus (SLE) is approximately 30 to 53 per 100,000. Severe dengue, however, is rarely reported among individuals with SLE. Here, whether sera of patients with SLE cross‐neutralize dengue virus (DENV) was investigated. Serum samples were obtained from individuals with SLE who were dengue IgG and IgM serology negative. Neutralization assays were performed against the three major DENV serotypes. Of the dengue serology negative sera of individuals with SLE, 60%, 61% and 52% of the sera at 1/320 dilution showed more than 50% inhibition against dengue type‐1 virus (DENV‐1), DENV‐2 and DENV‐3, respectively. The neutralizing capacity of the sera was significantly greater against DENV‐1 (P < 0.001) and DENV‐3 (P < 0.01) than against DENV‐2 (P < 0.05). Neutralization against the DENV correlated with dengue‐specific IgG serum titers below the cut‐off point for dengue positivity. Depletion of total IgG from the sera of patients with SLE resulted in significant decreases of up to 80% in DENV inhibition, suggesting that IgG plays an important role. However, some of the SLE sera was still able to neutralize DENV, even with IgG titers <0.1 OD absorbance. Our findings suggest that sera of patients with SLE contain IgG, and possibly other type of antibodies, that can cross‐neutralize DENV, which may explain the rarity of severe dengue in individuals with SLE. Further studies, are needed to further substantiate this finding and to elucidate the specific neutralizing epitopes recognized by the sera of individuals with SLE.

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“…IgE is involved in atopic and non‐atopic diseases [25] and has been shown to play a role in parasite, viral, spirochete and bacterial infections [26]. Previous studies in our laboratory were the first to demonstrate that IgE is important in parvovirus B19 immunity [12, 22], selective IgA immunodeficiency [12] and HIV‐1 progression [27, 28]. In this study we found IgE+ cells in the placental membrane as well as CD8+CD60+ T cells in the chorionic villi.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies in our laboratory have been the first to demonstrate an increase in numbers of blood CD8+CD60+ T cells in Parvovirus B19 infection [12]. A number of functions have been ascribed to CD60+ T cells.…”

Section: Introductionmentioning

confidence: 99%

CD8+CD60+ T Cells, Cells Expressing Epsilon Specific mRNA and Th1/Th2 Cytokines in Cord Blood and at 7 Months of Age

et al. 2008

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IgE levels in cord blood have been investigated as predictors of atopy, but no definitive findings have been made. Other factors, including cells and/or cytokines may serve as predictors of this disease. Cord blood and peripheral blood was obtained at birth and at 7 months of age, respectively, from children (n = 2) with a family history of allergy. Cells in cord blood and peripheral blood were phenotyped and levels of serum immunoglobulins (IgM, IgG, IgA and IgE) were determined. In addition, placentas from these pregnancies were obtained and stained for IgE+ cells and CD8+CD60+ T cells. We found immunoglobulin levels were within normal ranges although IgE levels were negligible in cord blood and at 7 months of age. Similar numbers of CD8+ T cells and CD19+ B cells were detected in cord blood and at 7 months of age. However, CD4+ T cells increased (twofold) and CD16+/CD56+ natural killer precursor cells decreased (twofold) at 7 months of age. CD8+ T cells in their cord blood and at 7 months of age comprised of >50% CD8+CD60+ T cells. Cord blood cells expressed epsilon‐specific mRNA and mRNA for interleukin‐2 (IL‐2), IL‐4, IL‐10 and interferon‐γ (IFN‐γ) but not IL‐6. At 7 months of age, peripheral blood mononuclear cells expressed epsilon‐specific mRNA and mRNA for all cytokines. In the placental membrane, we detected IgE+ cells, while CD8+CD60+ T cells were detected in the chorionic villi. CD8+CD60+ T cells, cells expressing epsilon‐specific and IL‐6‐specific mRNA may contribute to the pathobiology and provide important prognostic indicators of atopy.

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IgE, CD8+CD60+ T Cells and IFN-α in Human Immunity to Parvovirus B19 in Selective IgA Deficiency

Cited by 10 publications

References 45 publications

IgE Anti‐Borrelia burgdorferi Components (p18, p31, p34, p41, p45, p60) and Increased Blood CD8⁺CD60⁺ T Cells in Children with Lyme Disease

IgE Anti‐Borrelia burgdorferi Components (p18, p31, p34, p41, p45, p60) and Increased Blood CD8⁺CD60⁺ T Cells in Children with Lyme Disease

Sera of patients with systemic lupus erythematosus cross‐neutralizes dengue viruses

CD8+CD60+ T Cells, Cells Expressing Epsilon Specific mRNA and Th1/Th2 Cytokines in Cord Blood and at 7 Months of Age

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IgE, CD8+CD60+ T Cells and IFN-α in Human Immunity to Parvovirus B19 in Selective IgA Deficiency

Cited by 10 publications

References 45 publications

IgE Anti‐Borrelia burgdorferi Components (p18, p31, p34, p41, p45, p60) and Increased Blood CD8+CD60+ T Cells in Children with Lyme Disease

IgE Anti‐Borrelia burgdorferi Components (p18, p31, p34, p41, p45, p60) and Increased Blood CD8+CD60+ T Cells in Children with Lyme Disease

Sera of patients with systemic lupus erythematosus cross‐neutralizes dengue viruses

CD8+CD60+ T Cells, Cells Expressing Epsilon Specific mRNA and Th1/Th2 Cytokines in Cord Blood and at 7 Months of Age

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Resources

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IgE Anti‐Borrelia burgdorferi Components (p18, p31, p34, p41, p45, p60) and Increased Blood CD8⁺CD60⁺ T Cells in Children with Lyme Disease

IgE Anti‐Borrelia burgdorferi Components (p18, p31, p34, p41, p45, p60) and Increased Blood CD8⁺CD60⁺ T Cells in Children with Lyme Disease