Detection of hypervascular hepatocellular carcinoma by using spiral volumetric CT: Comparison of US and MR imaging

Ueda, Kazuhiko; Kitagawa, Kiyotaka; Kadoya, Masumi; Matsui, Osamu; Takashima, Tsutomu; Yamahana, Teruo

doi:10.1007/bf01256709

Cited by 30 publications

(24 citation statements)

References 35 publications

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“…In previous studies, the sensitivity for HCC was 72-75% with dynamic MRI and 47-50% with spin-echo MRI (8,9,15). In the present study, the conventional MRI showed similar sensitivity while the SENSE MRI showed higher sensitivity (91.7%) compared with the previous studies.…”

Section: Discussionsupporting

confidence: 60%

Double arterial phase dynamic MRI with sensitivity encoding (SENSE) for hypervascular hepatocellular carcinomas

Yoshioka

Takahashi

Yamaguchi

et al. 2002

Magnetic Resonance Imaging

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Purpose:To investigate the efficacy of SENSE MRI, including the double arterial phase dynamic study, to detect hypervascular hepatocellular carcinomas (HCCs). Materials and Methods:MRI of the liver was performed in 40 consecutive patients (20 by conventional MRI and 20 by SENSE MRI). The SENSE technique was used to obtain breath-hold T1-weighted FSE images (TR/TE ϭ 556/12 msec), respiratory-triggered T2-weighted FSE images (TR/ TE ϭ 1800/90 msec) with and without fat suppression, and dynamic MR images (TR/TE/FA ϭ 160 -168/4.6 msec/70°). In each arterial dominant phase and portal dominant phase, two scans were consecutively performed with one breathhold, leading to the double arterial phase and double portal phase images with SENSE. Results:The sensitivity of SENSE MRI for HCCs diagnosed from all MR images, including dynamic study, T1-weighted images, and T2-weighted images, was 91.7%, while that of conventional MRI was 76.3%. The positive predictive value of SENSE MRI for HCCs was 91.7%, while that of conventional MRI was 87.9%. In terms of HCCs Յ 10 mm, the sensitivity and positive predictive values of SENSE MRI were 78.6% and 78.6%, respectively, while those of conventional MRI were 27.3% and 60.0%, respectively. The number of detected HCCs Յ 10 mm was significantly larger in SENSE MRI than in conventional MRI (P Ͻ 0.05). The cause of false-positive lesions on SENSE MR images was an arterioportal shunt.Conclusion: SENSE MRI with double arterial phase dynamic study showed higher sensitivity compared to the conventional technique. Therefore, SENSE MRI is a promising method for the detection of HCC.

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Section: Discussionsupporting

confidence: 60%

Double arterial phase dynamic MRI with sensitivity encoding (SENSE) for hypervascular hepatocellular carcinomas

Yoshioka

Takahashi

Yamaguchi

et al. 2002

Magnetic Resonance Imaging

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“…13,14,38 Tumor vascularity is usually high in HCC compared to other liver tumors. 39,40 We speculate that hypovascular HCCs are difficult to PCNA, proliferating cell nuclear antigen * P Ͻ 0.01; ** P Ͻ 0.05 a Mean value of microvessel count detect by conventional imaging and to treat by chemoembolization or other therapy, and that treatment selection is therefore limited. In patients in whom repeated hepatectomy is impossible, survival in those patients with hypovascular HCC would be poorer after recurrence.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical analysis of tumor biological factors in hepatocellular carcinoma: relationship to clinicopathological factors and prognosis after hepatic resection

Nanashima

Yano

Yamaguchi

et al. 2004

Journal of Gastroenterology

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“…We have been following a large number of patients with chronic viral liver disease at regular intervals for early detection. After the installment of the helical computed tomography (CT) combined with angiography system in 2000, we have been carrying out helical CT angiography, namely CT arterial portography (CTAP) and CT hepatic arteriography (CTHA), whenever suspicion of HCC arises in patients; it is well established that helical CT angiography is highly diagnostic for hypervascular HCC 8,9 . We have so far found small HCC less than 2 cm in diameter in 29 patients.…”

Section: Introductionmentioning

confidence: 99%

Computed tomography angiographic findings in hepatocellular carcinoma less than 2 cm detected during follow‐up in 29 patients

Iwamoto¹,

Sanefuji²,

Okuda

2003

J of Gastro and Hepatol

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Detection of hypervascular hepatocellular carcinoma by using spiral volumetric CT: Comparison of US and MR imaging

Abstract: We suggest that the combination of precontrast SVCT and CT-ADP is an essential modality to screen for HCC in patients with chronic liver disease. CT-EP did not contribute to the detection of hypervascular HCC.

Cited by 30 publications

References 35 publications

Double arterial phase dynamic MRI with sensitivity encoding (SENSE) for hypervascular hepatocellular carcinomas

Double arterial phase dynamic MRI with sensitivity encoding (SENSE) for hypervascular hepatocellular carcinomas

Immunohistochemical analysis of tumor biological factors in hepatocellular carcinoma: relationship to clinicopathological factors and prognosis after hepatic resection

Computed tomography angiographic findings in hepatocellular carcinoma less than 2 cm detected during follow‐up in 29 patients

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