Detection of human pathogenic Ehrlichia muris-like agent in Peromyscus leucopus

Castillo, Caroline; Eremeeva, Marina E.; Paskewitz, Susan M.; Sloan, Lynne M.; Lee, Xia; Irwin, William E.; Tonsberg, Stefan; Pritt, Bobbi S.

doi:10.1016/j.ttbdis.2014.11.006

Cited by 23 publications

(19 citation statements)

References 8 publications

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“…I. scapularis was demonstrated experimentally to be a vector of E. muris eauclarensis [20,66], supporting earlier reports of natural infection in I. scapularis from Minnesota and Wisconsin [65,67,68]. E. muris eauclarensis has been detected in naturally infected white-footed mice collected in these two states [69], and reservoir competence was demonstrated in the laboratory [66]. …”

Section: The Number Of Recognized Human Disease Agents Transmitted Bysupporting

confidence: 65%

The Blacklegged Tick, Ixodes scapularis : An Increasing Public Health Concern

Eisen

2018

Trends in Parasitology

282

202

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In the United States, the blacklegged tick, Ixodes scapularis, is a vector of seven human pathogens, including those causing Lyme disease, anaplasmosis, babesiosis, Borrelia miyamotoi disease, Powassan virus disease, and ehrlichiosis associated with Ehrlichia muris eauclarensis. In addition to an accelerated rate of discovery of I. scapularis-borne pathogens over the past two decades, the geographic range of the tick, and incidence and range of I. scapularis-borne disease cases, have increased. Despite knowledge of when and where humans are most at risk of exposure to infected ticks, control of I. scapularis-borne diseases remains a challenge. Human vaccines are not available, and we lack solid evidence for other prevention and control methods to reduce human disease. The way forward is discussed.

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Section: The Number Of Recognized Human Disease Agents Transmitted Bysupporting

confidence: 65%

The Blacklegged Tick, Ixodes scapularis : An Increasing Public Health Concern

Eisen

2018

Trends in Parasitology

282

202

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“…The white-footed mouse, P. leucopus , has been implicated as a potential reservoir for EMLA in nature. Yet, only a small percentage of blood samples collected from wild mice are positive for EMLA DNA (two of 146; 1.4%) (Castillo et al 2015). EMLA does not persist for very long in the blood of an infected mouse.…”

Section: Discussionmentioning

confidence: 99%

Co-Feeding Transmission of theEhrlichia muris–Like Agent to Mice (Mus musculus)

Karpathy

Allerdice

Sheth

et al. 2016

Vector-Borne and Zoonotic Diseases

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The Ehrlichia muris–like agent (EMLA) is a newly recognized human pathogen found in Wisconsin and Minnesota. Ecological investigations have implicated both the blacklegged tick, Ixodes scapularis, and the white-footed mouse, Peromyscus leucopus, as playing roles in the maintenance of EMLA in nature. The work presented here shows that I. scapularis is an efficient vector of EMLA in a laboratory mouse model, but that Dermacentor variabilis, another frequent human biting tick found in EMLA endemic areas, is not. Additionally, I. scapularis larvae are able to acquire EMLA through co-feeding with infected nymphs. As EMLA only persists in mouse blood for a relatively short period of time, co-feeding transmission may play an important role in the maintenance of EMLA in ticks, and subsequently may play a role in limiting the geographic distribution of this pathogen in areas where co-feeding of larvae and nymphs is less common.

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“…The natural history of E. muris subsp. eauclairensis is incompletely characterized but probably involves small rodent hosts; wild-caught specimens of infected Peromyscus leucopus have been identified [11]. In the laboratory setting E. muris subsp.…”

Section: Description Of Ehrlichia Muris Subsp Muris Subsp Novmentioning

confidence: 99%

“…DNA from this bacterium was detected in Ixodes scapularis (black-legged ticks) [8][9][10] and blood of Peromyscus leucopus collected in Minnesota and Wisconsin [11].…”

mentioning

confidence: 99%