Detection of human papilloma virus DNA sequences in oral squamous cell papillomas by the polymerase chain reaction

Oral squamous papilloma: clinical, histologic and immunohistochemical analyses

“…It has also been suggested that all oral papillomas harbor the DNA sequence of HPV (15). In our study, the presence of koilocyte-like cells in all the slides can be considered highly suggestive of viral infection.…”

“…In our study, the presence of koilocyte-like cells in all the slides can be considered highly suggestive of viral infection. The DNA sequences of HPV 6 and 11 have been detected in 50 to 68% of oral papillomas (3,15). Of the 14 papillomas evaluated by Fregonesi et al (14) using in situ hybridization, 14% (2) were positive for HPV 6/11, 22% (n = 3) were positive for HPV 16/18, and the great majority (64%, 9) were negative for HPV.…”

Human papillomaviruses in oral squamous cell carcinoma and pre-cancerous lesions detected by PCR-based gene-chip array

“…Many previous studies have demonstrated the presence of HPV in oral epithelial tissue 4,5,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] , but the relationship of HPV to OSCC remains unclear because of the difficulty in interpreting the variations in reported prevalence of HPV in this condition. This study was designed to investigate the prevalence and typing of HPV infection in patients with both cancerous and pre-cancerous oral mucosal lesions, and to compare these with findings from a group of normal control subjects without oral mucosal disease.…”

Correlação da infecção viral pelo papilomavírus humano com as lesões papilomatosas e o carcinoma epidermóide na boca e orofaringe

“…Quanto à distribuição histológica da casuística e à presença do HPV, verificamos (Tabela 3) o predomínio nos papilomas (100%), seguido das hiperplasias (95%) e finalmente pelos carcinomas (44,7%), que talvez possa ser explicado pelo aumento de práticas sexuais orais, e, em se tratando de lesões benignas (papilomas e hiperplasias), prevalecem em adolescentes e adultos jovens 12,13 . Ao lado disso, próteses mal-adaptadas podem determinar o sangramento de hiperplasias, apesar de sua menor freqüência quando desenvolvida a partir do trauma mecânico 11 .…”

“…Há pelo menos um consenso entre os autores 4,9,13,20 e a nossa pesquisa, no qual o papiloma ocorreu no adulto jovem, apesar da maior ocorrência ter sido na segunda década de vida. Outro fato coincidente com a literatura foi o local de acometimento do papiloma, com predomínio na língua em 75% dos casos.…”