Human papillomaviruses in oral squamous cell carcinoma and pre-cancerous lesions detected by PCR-based gene-chip array

Luo, Chin Wan; Roan, Cheng Hsiung; Liu, Chung Ji

doi:10.1016/j.ijom.2006.09.005

Cited by 60 publications

(40 citation statements)

References 23 publications

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“…Rarer types detected in oral cancers were HPV8, HPV31, HPV38, and HPV66 [56,68,93]. Low-risk HPV is rarely detected in oral cancers, and when present might represent a ''bystander'' infection rather than possibly ''driver'' infection [37,42,64,68,80]. HPV RNA and Oral Cavity Cancer…”

Section: Resultsmentioning

confidence: 99%

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

Isayeva

Maswahu

et al. 2012

Head and Neck Pathol

224

218

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Perhaps one of the most important developments in head and neck oncology of the past decade is the demonstration that patients with human papillomavirus (HPV)-mediated oropharyngeal cancers have significantly improved outcomes, compared to HPV-negative counterpart patients. This has become the basis for clinical trials investigating the impact on ''treatment deintensification'' for patients with HPV-mediated oropharyngeal cancers. Unfortunately, the significance of HPV in non-oropharyngeal head and neck cancers is much less certain. Our goal is to systematically review the published data regarding the role HPV in carcinomas of the oral cavity, larynx, sinonasal tract and nasopharynx with respect to HPV detection frequency, viral activity, and association with outcome. We also present preliminary data on HPV16/18 transcriptional status in oral cavity carcinomas, as well as salivary gland neoplasia, as determined by nested reverse transcription PCR for HPV E6/E7 RNA. The weighted prevalence (WP) of HPV DNA detection in 4,195 oral cavity cancer patients is 20.2 %, (95 % CI 16.0 %, 25.2 %). HPV16 is the most common type detected. Importantly, no data currently demonstrates a significant association between the presence of HPV DNA and improved outcome. The WP of HPV DNA in 1,712 laryngeal cancer patients is 23.6 %, (95 % CI 18.7 %, 29.3 %). Similarly, no association has yet been demonstrated between HPV DNA status and outcome. The WP of HPV DNA detection in 120 sinonasal cancer patients is 29.6 % (95 % CI 17.8 %, 44.9 %), and in 154 nasopharyngeal carcinoma patients is 31.1 %, (95 % CI 20.3 %, 44.5 %). Recent preliminary data also suggests an association between HPV and certain salivary gland neoplasms. The clinical significance of these findings is unclear. The published data strongly support the need for studies on patients with oral and laryngeal carcinomas that will be powered to find any differences in clinical outcome with respect to HR-HPV and p16 overexpression.

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Section: Resultsmentioning

confidence: 99%

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

Isayeva

Maswahu

et al. 2012

Head and Neck Pathol

224

218

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“…33 On the other hand, exfoliative cytology is less invasive than a biopsy, it permits the harvesting of cells from a greater surface area and involves a lower risk of contamination prior to DNA extraction than a surgical procedure. 26,34,35 In order to reduce possible biases in this study due to the inclusion of SCC originating from sites other than the oral cavity (strictly defined) and to minimise the use of the less efficient virological test, a classification of tumour site, according to the AJCC criteria, was deployed and a very sensitive method of HPV detection was used for both specimens. The HPV DNA detection method applied in this study is currently considered the gold standard for identification of all possible HPV types.…”

Section: Discussionmentioning

confidence: 99%

Biopsy vs. brushing: Comparison of two sampling methods for the detection of HPV-DNA in squamous cell carcinoma of the oral cavity

et al. 2012

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“…Oral squamous cell carcinoma (OSCC) accounts for over 90 percent of oral cancers (1). Established etiological factors of OSCC included cigarette smoking, heavy alcohol abuse, betel nut chewing, and smokeless tobacco use.…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus in saliva of patients with oral squamous cell carcinoma

Sahebjamee¹,

Boorghani²,

Ghaffari³

et al. 2009

Med Oral

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Objective: The aim of this study was to evaluate the presence of human papillomavirus (HPV) in saliva rinses of patients with oral squamous cell carcinoma (OSCC)and to analyze the possibility of using saliva as a diagnostic method for screening high-risk patients. Study design: The saliva sample of 22 patients with oral squamous cell carcinoma and 20 age-sex matched healthy controls were obtained. The presence of HPV 6, 11, 16, 18, 31, and 33 was evaluated by polymerase chain reaction (PCR). Results: In 40.9% of the patients and in 25% of the controls, the saliva was shown to be positive for HPV. In 27.3% of the patients and in 20% of the controls, the saliva was shown to be positive for HPV16; and none of the controls, except one patient was shown to be positive for HPV 18. Neither patients nor controls were positive for HPV 31 and 33. These differences were not statistically significant. Conclusions: The results of this study were unable to support the detection of HPV in saliva rinses as a diagnostic method for OSCC.

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Human papillomaviruses in oral squamous cell carcinoma and pre-cancerous lesions detected by PCR-based gene-chip array

Cited by 60 publications

References 23 publications

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

Biopsy vs. brushing: Comparison of two sampling methods for the detection of HPV-DNA in squamous cell carcinoma of the oral cavity

Human papillomavirus in saliva of patients with oral squamous cell carcinoma

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