Detection of Human Metapneumovirus From Children With Acute Otitis Media

Suzuki, Akira; Watanabe, Oshi; Okamoto, Michiko; Endo, Hideki; Yano, Hisakazu; Suetake, Mitsuko; Nishimura, Hidekazu

doi:10.1097/01.inf.0000168755.01196.49

Cited by 35 publications

(22 citation statements)

References 9 publications

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“…Complications of AOM can be severe and require hospitalization or surgical intervention [17]. Our study adds to the two previous reports on hMPV and AOM [18,19]. The detection of hMPV in 1/144 MEF does not definitively establish a direct role for hMPV in middle ear pathogenesis.…”

Section: Discussionmentioning

confidence: 34%

Association of human metapneumovirus with acute otitis media

Williams¹,

Tollefson²,

Nair³

et al. 2006

International Journal of Pediatric Otorhinolaryngology

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SummaryObjective-Human metapneumovirus (hMPV) is a recently described paramyxovirus that has been associated with acute upper and lower respiratory infection (LRI) in infants and children worldwide. We previously observed that one-third of the children with hMPV-associated LRI had been diagnosed with a concomitant acute otitis media (AOM). In the current study, we sought to investigate an association between hMPV and children presenting with AOM as a primary diagnosis.Methods-We used realtime RT-PCR for hMPV to retrospectively test 144 paired nasal wash (NW) and middle ear fluid (MEF) specimens that had been prospectively collected from children with AOM during a 3-year period from 1990-1992. RNA was extracted from archived, frozen samples and realtime RT-PCR for hMPV was performed.Results-We detected hMPV in 8/144 (6%) NW and 1/144 MEF. Several of the children still tested positive for hMPV in NW 3 days later, showing persistent virus shedding. All were detected from November-May and six had bacterial co-pathogens. Two of the eight (25%) hMPV-infected children had no bacterial pathogen isolated, suggesting that hMPV may be associated with AOM as a sole pathogen.Conclusions-These data show that hMPV is associated with a proportion of AOM and thus has additional morbidity and healthcare impact related to these illnesses.

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Section: Discussionmentioning

confidence: 34%

Association of human metapneumovirus with acute otitis media

Williams¹,

Tollefson²,

Nair³

et al. 2006

International Journal of Pediatric Otorhinolaryngology

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“…Further studies are needed to clarify the importance of antigenic variation of HMPV in human populations with respect to the clinical course of infection. HMPV is associated with acute otitis media, and viral RNA can be detected in middle ear fluid (199,217,252).…”

Section: Symptoms and Pathologymentioning

confidence: 99%

“…It has been shown that 30 to 85% of children hospitalized with HMPV have chronic conditions, such as asthma, chronic lung disease due to prematurity, congenital heart disease, or cancer (29,63,72,168,173,225,234). Hospitalization of adults or children for HMPV-associated lower respiratory tract infections is more likely for patients with underlying conditions such as asthma, chronic obstructive pulmonary disease (COPD), HIV infection, immunocompromised status, or prematurity (34,66,75,78,106,122,163,168,187,193,217,229,242,253,254).…”

Section: Risk Groups Other Than Childrenmentioning

confidence: 99%

Human Metapneumovirus: Lessons Learned over the First Decade

Schildgen

Hoogen²,

Fouchier³

et al. 2011

Clin Microbiol Rev

182

187

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SUMMARY It has been 10 years since human metapneumovirus (HMPV) was identified as a causative agent of respiratory illness in humans. Since then, numerous studies have contributed to a substantial body of knowledge on many aspects of HMPV. This review summarizes our current knowledge on HMPV, HMPV disease pathogenesis, and disease intervention strategies and identifies a number of areas with key questions to be addressed in the future.

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“…However, the role of hBOV as a causative URI pathogen has been debated (3,23,25). Human metapneumovirus (hMPV), described in 2001 (32), also has been isolated from middle ear fluid samples from children with AOM (29,31). Retrospective analyses indicated that more than half of URI episodes due to hMPV were complicated by AOM (35).…”

mentioning

confidence: 99%

Viral-Bacterial Interactions and Risk of Acute Otitis Media Complicating Upper Respiratory Tract Infection

et al. 2011

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Acute otitis media (AOM) is a common complication of upper respiratory tract infection whose pathogenesis involves both viruses and bacteria. We examined risks of acute otitis media associated with specific combinations of respiratory viruses and acute otitis media bacterial pathogens. Data were from a prospective study of children ages 6 to 36 months and included viral and bacterial culture and quantitative PCR for respiratory syncytial virus (RSV), human bocavirus, and human metapneumovirus. Repeated-measure logistic regression was used to assess the relationship between specific viruses, bacteria, and the risk of acute otitis media complicating upper respiratory tract infection. In unadjusted analyses of data from 194 children, adenovirus, bocavirus, Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis were significantly associated with AOM (P < 0.05 by 2 test

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Detection of Human Metapneumovirus From Children With Acute Otitis Media

Cited by 35 publications

References 9 publications

Association of human metapneumovirus with acute otitis media

Association of human metapneumovirus with acute otitis media

Human Metapneumovirus: Lessons Learned over the First Decade

Viral-Bacterial Interactions and Risk of Acute Otitis Media Complicating Upper Respiratory Tract Infection

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