Association of human metapneumovirus with acute otitis media

Williams, John V.; Tollefson, Sharon J.; Nair, Sangeeta; Chonmaitree, Tasnee

doi:10.1016/j.ijporl.2005.12.007

Cited by 40 publications

(28 citation statements)

References 22 publications

(36 reference statements)

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“…Of importance, however, is the high rate of AOM as a complication of hMPV infection. Together with similar reports by other investigators (12,13,27), hMPV has a particularly strong ability to predispose a child to AOM. This underscores the clinical similarity between hMPV and respiratory syncytial virus, which is also a major viral cause of AOM in children (28)(29)(30).…”

Section: Discussionsupporting

confidence: 79%

Human Metapneumovirus Infections in Children

Heikkinen

Österback

Peltola

et al. 2008

Emerg. Infect. Dis.

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Human metapneumovirus (hMPV) is an important cause of lower respiratory tract infections in hospitalized children, but the age-related incidence and effect of hMPV in unselected children in the community have not been evaluated. We studied a cohort of 1,338 children <13 years of age throughout 1 respiratory season in Finland during [2000][2001]. We examined children and obtained a nasal swab for viral detection at any sign of respiratory infection. hMPV was detected in 47 (3.5%) of the 1,338 children. The age-related incidence of hMPV infection was highest (7.6%) in children <2 years of age, in whom hMPV accounted for 1.7% of all infections during the season. During the epidemic peak, hMPV caused 7.1% of all respiratory infections in the cohort. Acute otitis media developed in 61% of hMPVinfected children <3 years of age. Our fi ndings demonstrate that the effect of hMPV in the community is greatest in children <2 years of age.

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Section: Discussionsupporting

confidence: 79%

Human Metapneumovirus Infections in Children

Heikkinen

Österback

Peltola

et al. 2008

Emerg. Infect. Dis.

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“…A similar association has been found for hMPV, with this finding complicating a third to one half of cases [48,80]. Moreover, hMPV has been detected in sterile middle ear fluid of children with otitis media, suggesting that hMPV may sometimes play a direct causative role in this disease in the absence of bacterial pathogens [84].…”

Section: Upper Respiratory Tract Infectionssupporting

confidence: 69%

The distinguishing features of human metapneumovirus and respiratory syncytial virus

Papenburg

Boivin

2010

Reviews in Medical Virology

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Acute respiratory tract infections (RTIs) are a leading cause of morbidity and mortality worldwide. Human Metapneumovirus (hMPV) is a member of the Metapneumovirus genus within the Pneumovirinae subfamily of the Paramyxoviridae family. Though hMPV was only discovered in 2001, a large body of work has already shown that it is the aetiologic agent of a substantial proportion of upper and lower RTIs across all age groups in both healthy and immunocompromised hosts throughout the world. RSV, also a pneumovirus, is the human pathogen most closely related to hMPV. RSV is the leading cause of pneumonia and bronchiolitis in infants and young children, but can also cause respiratory tract disease in all age groups. In this paper, we will review the salient features of the virology, epidemiology, pathogenesis, host immune responses, clinical manifestations and diagnostic modalities of hMPV, using RSV as a comparison. In addition, we will show how immunoprophylactic and therapeutic strategies studied and used in clinical practice for RSV-some with great success, and others tragic failure-have led to promising areas of research for the prevention and treatment of the significant burden of disease caused by hMPV.

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“…These results are especially significant because Strptococcus pneumoniae is now known to be the leading cause of respiratory tract related deaths globally especially among children (Malinoski, 2006). Acute respiratory tract infections are also associated with viral infections (Williams et al, 2006). It is recommended that the plant extracts from this study be subjected to viruses related to respiratory diseases.…”

Section: Resultsmentioning

confidence: 91%

Ethnobotanical and Antimicrobial Studies of Some Plants Used in Kibwezi (Kenya) for Management of Lower Respiratory Tract Infections

Kariuki¹,

Njoroge²

2011

Afr. J. Trad. Compl. Alt. Med.

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Respiratory tract infections have gained worldwide recognition especially due to the increased incidence of HIV/AIDS. The bacteria responsible for these infections have also become increasingly resistant to chemotherapeutic agents in lower respiratory infections in Kibwezi in Kenya. Interviews were conducted using semi-structured questionnaires and detailed discussions with respondents. During the field surveys direct observations were made on how these plants are used. From the ethnobotanical survey the modes of preparation used included chewing and boiling. The plant parts used were mostly bark and root, which implies that the main methods of harvesting these plants are destructive in nature. Water and methanolic extracts of the three most popular plants, Acacia nilotica, Strychnos heninngsii and Microglossa densiflora were tested against three test organism: Staphylococcus aureus, Streptococcus pneumoniae and Escherichia coli for their antimicrobial properties. The efficacy of the extracts was tested by bioassay method using the disk diffusion test. It was interesting to note that none of the tested water extracts showed any activity against the test organisms. This is despite the fact that about 83% of the local people used water for extraction. Methanolic extracts of Acacia nilotica and Strychnos heninningsii showed efficacy against S. aureus, S. pneumoniae and E. coli. The findings of this research indicate that A. nilotica and S. heninngsii have antimicrobial properties and further work especially using mammalian models is recommended.

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Association of human metapneumovirus with acute otitis media

Cited by 40 publications

References 22 publications

Human Metapneumovirus Infections in Children

Human Metapneumovirus Infections in Children

The distinguishing features of human metapneumovirus and respiratory syncytial virus

Ethnobotanical and Antimicrobial Studies of Some Plants Used in Kibwezi (Kenya) for Management of Lower Respiratory Tract Infections

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