Detection of human herpesvirus 8 and human T-cell lymphotropic virus type 1 sequences in Kaposi sarcoma

Lebbe, Célèste

doi:10.1001/archderm.133.1.25

Cited by 20 publications

(18 citation statements)

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“…We confirm the presence of HHV-8 genomic sequences in 100% of the KS lesions and in 85% of the perilesional skin samples, as previously reported by other authors [15, 16, 33, 34]. As expected the skin was negative and the peripheral blood positive (by nested PCR) in 1 case only.…”

Section: Discussionsupporting

confidence: 91%

Human Herpesvirus 8 DNA in the Skin and Blood of Patients with Mediterranean Kaposi’s Sarcoma: Clinical Correlations

et al. 2001

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Background: Kaposi’s sarcoma is a multifocal lympho-angioproliferative disease that appears in elderly subjects of Mediterranean origin (classical form), young Africans and immunodepressed patients (as a result of organ transplantation or AIDS). In 1994, DNA sequences of a new human herpesvirus, called HHV-8, were detected in skin lesions and peripheral blood of patients with AIDS-related Kaposi’s sarcoma by confirmational display analysis and polymerase chain reaction. Objective: As HHV-8 in peripheral blood mononuclear cells is detected in about 50% of Mediterranean Kaposi’s sarcoma patients and its presence fluctuates in time in the same patient, maybe its detection correlates with the clinical behaviour of the disease. Methods: By using routine and nested polymerase chain reaction we evaluated the presence of HHV-8-specific DNA sequences in the skin lesions, perilesional healthy skin and peripheral blood mononuclear cells of a group of 40 HIV-negative patients with Mediterranean Kaposi’s sarcoma. Results: HHV-8 DNA sequences have been found in 40/40 (100%) lesional skin of Mediterranean Kaposi’s sarcoma, in 35/40 (85%) perilesional apparently normal skin and in 24/40 (60%) peripheral blood monuclear cell samples. The results of polymerase chain reaction on peripheral blood monuclear cells were positive in 41% of the patients with slowly evolving disease as opposed to 74% of those with rapidly evolving disease, and in 47.6% of the patients with stage I–II disease as opposed to 73.6% of those with stage III–IV. Conclusion: The detection of HHV-8 in peripheral blood monuclear cells seems to correlate with the more aggressive stages and the rapid evolution behaviour of Mediterranean Kaposi’s sarcoma.

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Section: Discussionsupporting

confidence: 91%

Human Herpesvirus 8 DNA in the Skin and Blood of Patients with Mediterranean Kaposi’s Sarcoma: Clinical Correlations

et al. 2001

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“…5 All forms are associated with HHV-8 infection. 6-9 The most common form seen in the United States is in association with AIDS followed by iatrogenic. 1,10 However, the prevalence of KS has decreased in the highly active antiretroviral treatment era.…”

Section: Discussionmentioning

confidence: 99%

Kaposi Sarcoma Mimicking Acute Flare of Ulcerative Colitis

Kumar

Soni

Garg

et al. 2017

Journal of Investigative Medicine High Impact Case Reports

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Besides an AIDS-defining illness, Kaposi sarcoma (KS) is also seen in individuals on long-term immunosuppressant therapy. We report KS in a 70-year-old immunocompetent man, which initially mimicked acute flare of ulcerative colitis (UC). He was hospitalized multiple times for complaints of watery diarrhea and tenesmus. Despite treatment with mesalamine, short courses of methylprednisolone, and one dose of infliximab, his symptoms improved only partially. He underwent colonoscopy, which revealed mild active colitis and a mass in the ascending colon. After treatment of acute flare with methylprednisone and mesalamine, he underwent total colectomy with end ileostomy. The histopathology confirmed stage I adenocarcinoma of colon. He continued to experience watery diarrhea, which was attributed to intractable UC, and he underwent protectomy several weeks later. The histopathology of rectum revealed KS. After surgery, watery diarrhea resolved completely. Review of literature suggests KS has been rarely reported in immunocompetent individuals with inflammatory bowel disease.

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“…Recently, a new herpesvirus, HHV‐8, initially identified by Chang et al 26 . in AIDS‐associated KS, has been described in classic, endemic, and post‐transplantation KS 11–13,27 , 28 . The putative virus shows significant sequence homology with Epstein–Barr virus and herpesvirus saimiri.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to immunosuppression, other factors, such as genetic predisposition, environmental and geographic factors, and oncogenic viruses, seem to be involved in a multifactorial pathogenic mechanism. Several recent studies have found herpesvirus‐like DNA sequences, indicated as KS‐associated herpesvirus or human herpesvirus 8 (HHV‐8), in various epidemiologic forms of KS, including post‐transplant KS 11–13 . This discovery suggests that this virus may play a role in the pathogenesis of KS.…”

Section: Introductionmentioning

confidence: 99%

Kaposi's sarcoma in renal transplant patients: experience at the Cruces Hospital in Bilbao

et al. 2003

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Detection of human herpesvirus 8 and human T-cell lymphotropic virus type 1 sequences in Kaposi sarcoma

Cited by 20 publications

References 0 publications

Human Herpesvirus 8 DNA in the Skin and Blood of Patients with Mediterranean Kaposi’s Sarcoma: Clinical Correlations

Human Herpesvirus 8 DNA in the Skin and Blood of Patients with Mediterranean Kaposi’s Sarcoma: Clinical Correlations

Kaposi Sarcoma Mimicking Acute Flare of Ulcerative Colitis

Kaposi's sarcoma in renal transplant patients: experience at the Cruces Hospital in Bilbao

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