2001
DOI: 10.1159/000051697
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Human Herpesvirus 8 DNA in the Skin and Blood of Patients with Mediterranean Kaposi’s Sarcoma: Clinical Correlations

Abstract: Background: Kaposi’s sarcoma is a multifocal lympho-angioproliferative disease that appears in elderly subjects of Mediterranean origin (classical form), young Africans and immunodepressed patients (as a result of organ transplantation or AIDS). In 1994, DNA sequences of a new human herpesvirus, called HHV-8, were detected in skin lesions and peripheral blood of patients with AIDS-related Kaposi’s sarcoma by confirmational display analysis and polymerase chain reaction. Objective: As HHV-8 in peripheral blood … Show more

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Cited by 33 publications
(28 citation statements)
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“…The presence of KSHVinfected B cells in the peripheral blood (13,138,340) and the ability of TPA-treated PEL cells to efficiently transmit KSHV to primary endothelial cells in culture (441) suggest that circulating B cells may help disseminate the virus to extralymphoid targets such as lymphatic endothelium, where the virus then establishes a secondary latent infection (483). Supporting this notion, active KSHV replication and increased viral load in the peripheral blood predicts the pathogenic outcome of the infection (410) and is strongly correlated with (i) increased risk of progression to KS (13,530) and (ii) increased severity of the pathogenic stage of KS (47,68). Furthermore, treatment of high-risk patients with the antiviral ganciclovir blocks lytic KSHV replication and reduces KS risk (324).…”
Section: Lytic Genes and Kshv Pathogenesismentioning
confidence: 92%
See 1 more Smart Citation
“…The presence of KSHVinfected B cells in the peripheral blood (13,138,340) and the ability of TPA-treated PEL cells to efficiently transmit KSHV to primary endothelial cells in culture (441) suggest that circulating B cells may help disseminate the virus to extralymphoid targets such as lymphatic endothelium, where the virus then establishes a secondary latent infection (483). Supporting this notion, active KSHV replication and increased viral load in the peripheral blood predicts the pathogenic outcome of the infection (410) and is strongly correlated with (i) increased risk of progression to KS (13,530) and (ii) increased severity of the pathogenic stage of KS (47,68). Furthermore, treatment of high-risk patients with the antiviral ganciclovir blocks lytic KSHV replication and reduces KS risk (324).…”
Section: Lytic Genes and Kshv Pathogenesismentioning
confidence: 92%
“…The lymphotropism of KSHV was demonstrated by PCR amplification of viral DNA from the CD19 ϩ B-cell subset of PBMCs from AIDS-associated KS patients (13,340), as well as in PEL specimens (80,161,245,267,366), suggesting a mechanism by which the virus may disseminate in the host. Active KSHV replication and increased detection by PCR of viral DNA in the peripheral blood are strongly correlated with (i) increased risk of progression to KS (13,530) and (ii) increased severity of pathogenic stage of KS (47,68); the peripheral viral load predicts the pathogenic outcome of the infection (410). KSHV has also been found in the neutrophil subset of PBMCs (285) (481).…”
Section: Histopathogenesis Of Ks and Its Relationship To Kshv Infectionmentioning
confidence: 99%
“…Clinicoepidemiologic studies indicate that KSHV lytic activation is a critical contributor to the pathogenesis of KS, PEL, and MCD (7)(8)(9)(10)(11)(12)(13). Lytic activation also correlates with disease progression and prognosis (14)(15)(16).…”
mentioning
confidence: 99%
“…An Mta mutant with a lesion in a putative A/T hook domain is altered in DNA binding and debilitated in transactivation. We propose that one molecular mechanism of Mtamediated transactivation is a direct effect on transcription by direct and indirect promoter association.Reactivation of Kaposi's-sarcoma associated herpesvirus (KSHV) (also known as human herpesvirus 8) from latency is a crucial step in Kaposi's sarcoma development (7,11,27,43,65,76,81,87,104). It is likely that reactivation of KSHV contributes to Kaposi's sarcoma development by facilitating dissemination of the virus from its B-cell reservoir and permitting the expression of lytic cycle genes with direct roles in cancer progression.…”
mentioning
confidence: 99%