Detection of human group C rotaviruses in Nigeria and sequence analysis of their genes encoding VP4, VP6, and VP7 proteins

Adah, Mohammed I.; Wade, Abel; Oseto, Mitsuaki; Kuzuya, Mitsutaka; Taniguchi, Koki

doi:10.1002/jmv.2141

Cited by 34 publications

(51 citation statements)

References 43 publications

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“…This indicates that the evolution or drift of these genes is slow. It is also very much in keeping with the results of other studies in which the sequences of these human group C rotavirus genes from isolates from a number of different countries were compared and a very high degree of sequence conservation was found (1,3,4,6,9). Our results, including the VP7 and VP4 gene sequence comparisons between the central Australian and overseas isolates, therefore confirm and extend the findings presented in the other studies.…”

Section: Discussionsupporting

confidence: 91%

“…Changes in the sequences of both the VP7 and VP4 genes were evident over the 7-year period but they were few, particularly relative to the differences in sequence between the equivalent human and animal group C rotavirus genes (1,3,4,6,9). This indicates that the evolution or drift of these genes is slow.…”

Section: Discussionmentioning

confidence: 96%

“…Group A rotaviruses are the most common cause of severe diarrhea in infants and young children, but they also infect adults (10). Group C rotavirus infection in humans occurs both in children and adults, usually in sporadic cases or clustered outbreaks, and has now also been identified worldwide (1,3,8,9,11,12,(14)(15)(16)(17)20). However, compared to group A rotaviruses, the identification of group C rotaviruses has been far less common, and neither the overall disease burden nor the epidemiology of this group of rotaviruses is yet entirely clear (9).…”

mentioning

confidence: 99%

“…Sequence variation is also evident between VP7 genes of human and animal group C rotaviruses, but among human group C rotavirus isolates themselves from many different parts of the world remarkable sequence conservation has been noted in this gene (1,3,6,9,11). A high degree of conservation has also been evident between the sequences of the VP4 genes of human group C rotavirus isolates from different parts of the world, but a greater difference was noted between these sequences and those of the VP4 genes of bovine and porcine group C rotavirus strains (1,4).…”

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confidence: 99%

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Incidence of Group C Human Rotavirus in Central Australia and Sequence Variation of the VP7 and VP4 Genes

et al. 2004

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Human group C rotavirus was identified in central Australia in each of eight years over a 16-year period between 1982 and 1997. Cases occurred either sporadically but over a relatively short period of time or as clustered outbreaks. These are the only reports of human group C rotavirus in Australia other than that of a single case reported approximately 1,800 km away in 1982. The electrophoretic genome profiles of isolates were identical for all those identified within the same year but different between those identified in different years. The VP7 genes of four isolates identified in four different years over a 7-year period between 1987 and 1993, and the VP4 genes of two of these isolates showed relatively little variation in genome and deduced amino acid sequence upon comparison of the equivalent genes between isolates. The sequences were also very similar to those from the corresponding genes from most of the human group C rotavirus isolates from other countries. This continues the observation of a high degree of gene sequence conservation among human group C rotaviruses worldwide.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 96%

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Incidence of Group C Human Rotavirus in Central Australia and Sequence Variation of the VP7 and VP4 Genes

et al. 2004

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“…Species B (RVBs) and H (RVHs) RVs are known to cause severe diarrhoea, primarily in adults (Rahman et al, 2007;Estes & Greenberg, 2013). Species C RVs (RVCs) have been detected in either sporadic cases or outbreaks of gastroenteritis worldwide, and the overall disease burden and epidemiology of this group of RVs remain to be investigated (Adah et al, 2002;Castello et al, 2009;Medici et al, 2009;Schnagl et al, 2004). †These authors contributed equally to this work.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the full genome of human group C rotaviruses reveals lineage diversification and reassortment

Medici

Tummolo

Martella

et al. 2016

Journal of General Virology

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Group C rotaviruses (RVC) are enteric pathogens of humans and animals. Whole-genome sequences are available only for few RVCs, leaving gaps in our knowledge about their genetic diversity. We determined the full-length genome sequence of two human RVCs (PR2593/ 2004 and PR713/2012), detected in Italy from hospital-based surveillance for rotavirus infection in 2004 and 2012. In the 11 RNA genomic segments, the two Italian RVCs segregated within separate intra-genotypic lineages showed variation ranging from 1.9 % (VP6) to 15.9 % (VP3) at the nucleotide level. Comprehensive analysis of human RVC sequences available in the databases allowed us to reveal the existence of at least two major genome configurations, defined as type I and type II. Human RVCs of type I were all associated with the M3 VP3 genotype, including the Italian strain PR2593/2004. Conversely, human RVCs of type II were all associated with the M2 VP3 genotype, including the Italian strain PR713/2012. Reassortant RVC strains between these major genome configurations were identified. Although only a few full-genome sequences of human RVCs, mostly of Asian origin, are available, the analysis of human RVC sequences retrieved from the databases indicates that at least two intra-genotypic RVC lineages circulate in European countries. Gathering more sequence data is necessary to develop a standardized genotype and intragenotypic lineage classification system useful for epidemiological investigations and avoiding confusion in the literature.

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Detection and molecular characterization of human group C rotaviruses in Okayama Prefecture, Japan, between 1986 and 2005

Kuzuya¹,

Fujii²,

Hamano³

et al. 2007

Journal of Medical Virology

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A survey of human group C rotaviruses (CHRVs) was conducted in Okayama Prefecture, Japan, over a period of 19 years between 1986 and 2005. The presence of CHRVs was screened by enzyme-linked immunosorbent assay using CHRV-specific monoclonal antibodies and confirmed by reverse transcription-PCR. Of the 3,722 fecal specimens from sporadic cases of gastroenteritis, 44 specimens (1.2%) were positive for CHRV. The CHRV isolates were detected periodically but continuously, and the rates of positivity changed from one rotavirus season to the next. Moreover, the isolates were mainly detected in April and May, and the mean age of the patients infected with CHRV was 5.27 years. The genome electropherotypes (E types) of the isolates were classified into three patterns, and the dominant pattern changed from year to year. Nucleotide sequences of the VP7 and VP4 genes of 16 strains, which were representatives of 70 isolates from sporadic cases and outbreaks, were determined and analyzed. Although the VP7 and VP4 genes of the strains were closely related to each other, a phylogenetic analysis suggested that each of the VP7 and VP4 genes of the strains were grouped into three genetic lineages. Moreover, the strains could be divided into five types based on the combination of the E type and the genetic lineages of the VP7 and VP4 genes. These results indicate that CHRVs generally exist in Okayama Prefecture and that CHRVs with various genomic backgrounds prevailed in a limited area.

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Detection of human group C rotaviruses in Nigeria and sequence analysis of their genes encoding VP4, VP6, and VP7 proteins

Cited by 34 publications

References 43 publications

Incidence of Group C Human Rotavirus in Central Australia and Sequence Variation of the VP7 and VP4 Genes

Incidence of Group C Human Rotavirus in Central Australia and Sequence Variation of the VP7 and VP4 Genes

Analysis of the full genome of human group C rotaviruses reveals lineage diversification and reassortment

Detection and molecular characterization of human group C rotaviruses in Okayama Prefecture, Japan, between 1986 and 2005

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