Detection of Human Bocavirus-2 in children with acute Gastroenteritis in South Korea

Han, Tae-Hee; Kim, Cheol Hwan; Park, Sang Hun; Kim, En Jung; Chung, Jin-Gyun; Hwang, Eung Soo

doi:10.1007/s00705-009-0533-3

Cited by 44 publications

(56 citation statements)

References 22 publications

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“…In this study, a similar detection rate for HBoV-1 was observed in both male and female children, which is in agreement with other studies conducted in other parts of the world , Han et al 2009). This finding reinforces data from previous investigations conducted in the region that show no difference in gastroenteric virus detection rates regardless of the children's gender (Camarota et al 1992, Borges et al 2006.…”

Section: Discussionsupporting

confidence: 93%

“…HBoV detection in faecal samples from individuals with acute gastroenteritis has gained importance following the positive identification of bocavirus in faecal samples from individuals throughout the world (Albuquerque et al 2007, Lau et al 2007, Monteny et al 2007, Vicente et al 2007, Han et al 2009, Chow et al 2010, Kantola et al 2010, Jin et al 2011. In Brazil, only three studies have been published regarding HBoV detection in children with acute gastroenteritis (Albuquerque et al 2007, Santos et al 2010, Proença-Modena et al 2011 and this is the first study conducted in the Central-West Region of Brazil.…”

Section: Discussionmentioning

confidence: 99%

“…of HBoVs in association with RVA and noroviruses (Arthur et al 2009, Han et al 2009, Nakanishi et al 2009). In the present investigation, a co-infection rate of 31.8% for HBoV-1 associated with RVA and Aichi virus was observed.…”

Section: Discussionmentioning

confidence: 99%

“…HBoV-2, HBoV-3 and HBoV-4 have mainly been detected in stool samples, with HBoV-2 and possibly HBoV-3 being associated with gastroenteritis , Jartti et al 2012. However, several studies (Campe et al 2008, Arthur et al 2009, Han et al 2009), including those conducted in Brazil (Albuquerque et al 2007, Santos et al 2010, have attempted to detect HBoVs in faecal samples obtained from individuals presenting with acute gastroenteritis.…”

mentioning

confidence: 99%

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Human bocavirus 1 and 3 infection in children with acute gastroenteritis in Brazil

Sousa¹,

Souza²,

Fiaccadori³

et al. 2012

Mem. Inst. Oswaldo Cruz

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To determine the positivity rate of human bocavirus (HBoV) 1 and 3 among children who presented with acute gastroenteritis symptoms during the period of 1994-2004 in the Central-West Region of Brazil, 762 faecal samples were tested using polymerase chain reaction (PCR) for the detection of HBoV DNA. Primers for a segment of the non-structural viral protein 1 (NS1) gene of HBoV-1 and HBoV-3 were used. Twelve HBoV-positive samples were further characterised via genomic sequencing and phylogenetic analysis. Of the samples tested, 5.8% (n = 44) were positive for HBoV-1 or HBoV-3 and co-infection was observed in 14 (31.8%) of the 44 HBoV-positive samples. Nine of the 14 samples were also positive for Rotavirus A and five were positive for Aichi virus. The genomic sequencing of the NS1 partial sequence of 12 HBoV-samples showed that 11 samples were characterised as HBoV-1 and that one was characterised as HBoV-3. The phylogenetic analysis showed that the HBoV-1 samples had a high sequence homology to others previously identified in China, Sweden and Brazil. This is the first study conducted in the Central-West Region of Brazil to detect HBoV-1 and HBoV-3 in faecal samples from children with acute gastroenteritis. Further studies are required to define the role of HBoVs as aetiological agents of gastroenteritis

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Human bocavirus 1 and 3 infection in children with acute gastroenteritis in Brazil

Sousa¹,

Souza²,

Fiaccadori³

et al. 2012

Mem. Inst. Oswaldo Cruz

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“…These data are confirmed by clinical observations indicating that the infection manifests as a respiratory condition. In contrast, hBoV2, hBoV3 and hBoV4 colonize the gastrointestinal tract; hBoV2 and possibly hBoV3 are associated with gastroenteritis [46,47]. Interestingly, hBoV2 is the only intestinal bocavirus isolated from a nasal swab; therefore it may be associated with respiratory diseases [48,49].…”

Section: Human Bocavirusmentioning

confidence: 99%

Emergence of new infections in the 21st century and identification of pathogens using next generation sequencing

et al. 2017

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Каждое новое инфекционное заболевание может быть серьезным вызовом для современной медицины. Измене-ние окружающей среды, вырубка тропических лесов, таяние льдов в Антарктике, увеличение плотности населения и повсеместное использование антибиотиков -все это факторы, провоцирующие появление новых патогенов. Эпидемии гриппа, вызываемые новыми штаммами вируса; респираторные синдромы, вызываемые новыми коро-навирусами; вспышки инфекций, причиной которых является гемолитическая кишечная палочка; возникновение резистентных к антибиотикам супербактерий -примеры того, какие опасности могут поджидать человечество. В число первоочередных мер, которые необходимо предпринять для противодействия новым патогенам, входит раз-работка способов их быстрой и точной идентификации. В обзоре рассмотрены случаи возникновения в XXI веке новых инфекционных агентов, а также проанализированы возможность и перспективы использования для выявления и идентификации новых патогенов методов высокопроизводительного секвенирования (next generation sequence).Ключевые слова: инфекционные агенты, патогенные организмы, методы выявления новых патогенов, высокопроиз-водительное секвенирование, коронавирус, вирус гриппа, горизонтальный перенос генов, антибиотикорезистентность CENTURY AND IDENTIFICATION OF PATHOGENS USING NEXT GENERATION SEQUENCINGEach new emerging infection may become a big challenge to the medical community. Changing environment, tropical deforestation, melting of the Antarctic ice, growing population density and uncontrolled use of antibiotics provoke emergence and evolution of pathogens. Epidemics caused by new strains of the influenza virus, respiratory syndromes associated with coronaviruses, outbreaks of hemolytic Escherichia coli infections and antibiotic-resistant superbacteria are hazards to humans. Among high-priority measures for pathogen control that are yet to be taken is development of fast and accurate techniques for pathogen identification. Our review looks at the cases of new infections registered in the 21 st century and explores feasibility of next generation sequencing for the detection and identification of new pathogens.

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Molecular detection and epidemiology of astrovirus, bocavirus, and sapovirus in Italian children admitted to hospital with acute gastroenteritis, 2008–2009

Medici

Tummolo

Albonetti

et al. 2012

Journal of Medical Virology

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Although a number of enteric viruses have been identified in children with acute gastroenteritis, the majority of cases of gastroenteritis remain undiagnosed. In order to provide more insights into the epidemiology of enteric viruses that are not included usually in routine diagnostic tests, cases of childhood sporadic gastroenteritis of unknown etiology requiring hospital admission in Parma, Italy, during 2008-2009, were screened for astrovirus (AstV), sapovirus (SaV), and bocavirus (BoV). The stools of 712 children, negative for rotavirus, norovirus, adenovirus, enterovirus, and reovirus, were examined by PCR or RT-PCR for AstV, BoV, and SaV. The prevalence of AstV, BoV, and SaV in the patients examined was 2.1%, 3.2%, 2.4%, respectively, with the viruses being detected mostly in children <3 years of age. AstV strains were characterized by sequencing as types 1, 2, and 4, with a AstV-1 peak occurring in the 2008 fall-winter season. BoV strains were characterized as types 1, 2, and 3, with BoV-3 circulating more frequently in the 2008 autumn and winter season and BoV-2 during March-April 2009. The most common SaVs were GI.2 and GII.1 while GIV and GV SaVs were detected sporadically. Overall, AstV, BoV, and SaV infections accounted for 7.7% of the sporadic cases of acute gastroenteritis with unknown etiology selected for the study. Different virus types and lineages were found to circulate and temporal peaks of virus activity were also demonstrated, suggesting either small clusters of infections or small outbreaks or epidemics in local population.

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Detection of Human Bocavirus-2 in children with acute Gastroenteritis in South Korea

Cited by 44 publications

References 22 publications

Human bocavirus 1 and 3 infection in children with acute gastroenteritis in Brazil

Human bocavirus 1 and 3 infection in children with acute gastroenteritis in Brazil

Emergence of new infections in the 21st century and identification of pathogens using next generation sequencing

Molecular detection and epidemiology of astrovirus, bocavirus, and sapovirus in Italian children admitted to hospital with acute gastroenteritis, 2008–2009

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