Detection of Hpdel in healthy individuals and cancer patients in Taiwan

Su, Yu Chieh; Chen, Yi‐Chun; Li, Szu-Chin; Lee, Ching‐Chih; Tung, Ya-Ting

doi:10.1515/cclm.2009.156

Cited by 12 publications

(6 citation statements)

References 24 publications

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“…HP del homozygotes are at risk for developing anaphylactic transfusion reactions if they produce antibodies (IgE) to HP 9,10 . This allele has been found only in East and Southeast Asian populations so far 8,9,[11][12][13][14][15][16][17][18][19] .…”

Section: Several Genetic Polymorphisms Of the Haptoglobin Gene (Hp) Omentioning

confidence: 96%

Haptoglobin polymorphisms in Latin American populations

Soejima

Koda

2020

Sci Rep

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were also divided into four groups, group 1 (all 45 AA/AA, AA/CA, CA/CA), group 2 (26 of 42 AA/AG), group 3 (16 of 42 AA/AG and all of 10 AG/CA), and group 4 (all of 25 AG/AG) (Fig. 1C,D). One individual had a rare base substitution at position of − 68 (rs55663121) as a heterozygote (T/C). The genotype of this individual was A/A at rs5471 and rs5472, and it belonged to group 3 of rs5471and group 1 of rs5472. In any case, we determined six rs5471 and rs5472 haplotypes accurately except one subject (heterozygote of rs55663121) when we comprehensively considered both HRM results for rs5471 and rs5472 (Table 1). We then determined the haplotypes of rs5471 and rs5472 in 416 Latin American individuals (Table 2).

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Section: Several Genetic Polymorphisms Of the Haptoglobin Gene (Hp) Omentioning

confidence: 96%

Haptoglobin polymorphisms in Latin American populations

Soejima

Koda

2020

Sci Rep

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“…Three major genotypes are produced and have been identified by gel electrophoresis: Hp1-1, Hp1-2, and Hp2-2 ( 17 , 18 ). Hp Del has also been described in Japanese, Chinese, and Korean populations but has not been found in African or European populations ( 19 – 21 ). Several minor genotypes (Hp1-Johnson, Hp1-M, and Hp0) have also been described ( 22 ).…”

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confidence: 99%

Role of Haptoglobin in Health and Disease: A Focus on Diabetes

MacKellar¹,

Vigerust

2016

Clinical Diabetes

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In Brief Prospective identification of individuals with diabetes who are at greatest risk for developing complications would have considerable public health importance by allowing appropriate resources to be focused on those who would benefit most from aggressive intervention. Haptoglobin (Hp) is an acute-phase protein that is crucial for the elimination of free hemoglobin and the neutralization of oxidative damage. In the past two decades, associations have been made between polymorphisms in Hp and complications arising from diabetes. Individuals with polymorphism in Hp have been shown to have significantly higher risk of developing cardiovascular disease. This review summarizes the current literature on the role of Hp in health and disease, with a focus on diabetes.

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“…As mentioned above, distribution of this allele seemed to be restricted to East and Southeast Asia [6,12,13,20,22]. How did this result come about?…”

Section: Resultsmentioning

confidence: 84%