Detection of Herpesvirus DNA in Cerebrospinal Fluid and Correlation with Clinical Symptoms

Plentz, Annelie; Jilg, Wolfgang; Kochanowski, Bernd; Ibach, Bernd; Knöll, Antje

doi:10.1007/s15010-007-6354-y

Cited by 30 publications

(19 citation statements)

References 9 publications

(13 reference statements)

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“…In miscellanous neurological patients CNS "colonization" with EBV seems to be rare [6,7]. However, in infectious mononucleosis the CSF is often positive for EBV.…”

Section: Discussionmentioning

confidence: 99%

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Clinical characteristics of patients with Epstein Barr virus in cerebrospinal fluid

et al. 2011

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BackgroundThe role of Epstein-Barr (EBV) virus in central nervous system (CNS) infections is not fully resolved. It is clearly associated with lymphoproliferative disease of immunosuppressed persons, and may cause encephalitis.MethodsWe reviewed the medical records, imaging and laboratory findings of all patients EBV DNA PCR positive in cerebrospinal fluid (CSF) during 2000 to 2009 in the Helsinki University Central Hospital.ResultsWe identified 32 patients with EBV DNA in CSF. 11 had history of allogeneic hematopoietic stem cell transplantation, 7 solid organ transplantation and 5 HIV/AIDS. 5 patients had no preceding immunodeficiency.In 8 of the cases, another pathogen was identified in CSF. These were M. tuberculosis (2), T. gondii (2), Aspergillus (1), Herpes simplex virus 1 (1), C. neoformans (1) and Human herpesvirus 6 (1). Altogether in 15/32 (47%) of the cases the clinician had a strong suspicion of cause other than EBV for the patients' CNS symptoms/findings.Of note, 7 of 11 (64%) patients with stem cell transplantation had encephalitis (univariate odds ratio 5.6; confidence Interval 1.1-27.4). Of these 6 had no other pathogen identified.ConclusionsEBV DNA was often found together with other microbial findings in CSF of immunocompromised patients. EBV seems to be associated with encephalitis in stem cell transplant recipients.

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“…In miscellanous neurological patients CNS "colonization" with EBV seems to be rare [6,7]. However, in infectious mononucleosis the CSF is often positive for EBV.…”

Section: Discussionmentioning

confidence: 99%

“…In 208 patients with various neurological diseases, among whom the clinician did not request any herpesvirus PCR, no CSF sample was found positive for EBV [6]. Among 253 encephalitis patients studied in France in 2007, only 2,3% had EBV as etiology [7].…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of patients with Epstein Barr virus in cerebrospinal fluid

et al. 2011

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“…[99][100][101][102] Although HSV-1 preferentially lies dormant in neurons, the detection of HSV-1 DNA in the cerebrospinal fluid suggests that asymptomatic replication of HSV-1 may occur in the CNS under certain cirucumstances. 103,104 Given the intense interplay between HSV-1 and host cells, it is likely that recurrent HSV-1 reactivation may cumulatively arouse neuronal dysfunction, as demonstrated recently by Martin et al, 105 which shows that HSV-1 reactivation from latency induces neuroinflammation and the appearance of early neurodegenerative markers including MAPT/Tau phosphorylation. In line with this, independent analyses of large cohorts of subjects revealed a significantly increased risk for AD in patients with anti-HSV-1 IgM, a marker of viral primary infection or reactivation.…”

Section: Hsv-1-associated Autophagy Dysfunction: a Risk Factor For Nementioning

confidence: 93%

Autophagy interaction with herpes simplex virus type-1 infection

O’Connell

Liang

2016

Autophagy

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More than 50% of the U.S. population is infected with herpes simplex virus type-I (HSV-1) and global infectious estimates are nearly 90%. HSV-1 is normally seen as a harmless virus but debilitating diseases can arise, including encephalitis and ocular diseases. HSV-1 is unique in that it can undermine host defenses and establish lifelong infection in neurons. Viral reactivation from latency may allow HSV-1 to lay siege to the brain (Herpes encephalitis). Recent advances maintain that HSV-1 proteins act to suppress and/or control the lysosome-dependent degradation pathway of macroautophagy (hereafter autophagy) and consequently, in neurons, may be coupled with the advancement of HSV-1-associated pathogenesis. Furthermore, increasing evidence suggests that HSV-1 infection may constitute a gradual risk factor for neurodegenerative disorders. The relationship between HSV-1 infection and autophagy manipulation combined with neuropathogenesis may be intimately intertwined demanding further investigation.

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“…There is no clear evidence on whether HSV-1 reaching the brain and infecting neurons resides there in latent form. However, the detection of HSV-1 DNA in the cerebro-spinal fluid (Deatly et al, 1988; Peter and Sevall, 2001; Plentz et al, 2008) suggests that HSV-1 replicates in the CNS (Bearer, 2012). The presence of HSV-1 proteins in hippocampal neurons of mice infected intraperitoneally with HSV-1 was demonstrated by Burgos et al (2006a) who also showed that virus is reactivated by hyperthermia.…”

Section: How Can Hsv-1 Be Involved In Ad?mentioning

confidence: 99%

HSV-1 and Alzheimerâ€™s disease: more than a hypothesis

et al. 2014

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Among the multiple factors concurring to Alzheimer's disease (AD) pathogenesis, greater attention should be devoted to the role played by infectious agents. Growing epidemiological and experimental evidence suggests that recurrent herpes simplex virus type-1 (HSV-1) infection is a risk factor for AD although the underlying molecular and functional mechanisms have not been fully elucidated yet. Here, we review literature suggesting the involvement of HSV-1 infection in AD also briefly mentioning possible pharmacological implications of these findings.

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Detection of Herpesvirus DNA in Cerebrospinal Fluid and Correlation with Clinical Symptoms

Abstract: The detection of low-level herpesvirus replication in CSF by highly sensitive PCR assays requires critical evaluation.

Cited by 30 publications

References 9 publications

Clinical characteristics of patients with Epstein Barr virus in cerebrospinal fluid

Clinical characteristics of patients with Epstein Barr virus in cerebrospinal fluid

Autophagy interaction with herpes simplex virus type-1 infection

HSV-1 and Alzheimerâ€™s disease: more than a hypothesis

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