Detection of hepatitis E virus RNA and genotype in Bangladesh

Sugitani, Masahiko; Tamura, Akinori; Shimizu, Yohko K.; Sheikh, Aleemuzzaman; Kinukawa, Noriko; Shimizu, Kazufumi; Moriyama, Mitsuhiko; Komiyama, Kanki; Li, Tiancheng; Takeda, Naokazu; Arakawa, Yasuyuki; Suzuki, Koyu; Ishaque, S M; Roy, Projesh Kumar; Raihan, Asma; Hasan, Maruf

doi:10.1111/j.1440-1746.2008.05677.x

Cited by 11 publications

(7 citation statements)

References 25 publications

(33 reference statements)

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“…26 These findings confirm recent clinical studies identifying HEV as an etiologic agent contributing to substantial hepatitis morbidity in Bangladesh. 18,27,28 The rural population prevalence is lower than the 60.1% proposed by a recent urban study of 273 apparently healthy adults, 19 but similar to the 27% estimates of anti-HEV IgG prevalence in a study of 105 Bangladeshi peacekeepers participating in the United Nations Mission in Haiti in 1996. 17 A 1992 population serosurvey in southern India found an overall anti-HEV seroprevalence of 26%, 29 whereas other India estimates range from 4% to 64%, with varying sample sizes and age ranges using different assays.…”

Section: Discussionmentioning

confidence: 81%

Population Seroprevalence of Hepatitis E Virus Antibodies in Rural Bangladesh

Labrique¹,

Zaman²,

Hossain³

et al. 2009

The American Journal of Tropical Medicine and Hygiene

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Abstract. Hepatitis E virus (HEV) causes a substantial burden of sporadic and epidemic disease worldwide. HEV infections result in serious morbidity and mortality, especially among pregnant women, and have significant economic costs. Few population-based studies have characterized the epidemiology of HEV. A rural Bangladeshi population was studied to determine the age-and gender-specific population seroprevalence of antibodies to HEV. Of 1,134 specimens tested from a representative, random population sample, 255 (22.5%) were anti-HEV IgG seropositive. Seroprevalence was lower among women (19.7%) than among men (25.8%). We found anti-HBc (hepatitis B core) in 380 of 1080(35.2%) tested, anti-HCV (hepatitis C) in 14 of 917(1.5%) tested, and anti-HAV (hepatitis A) in 116 of 124(93.5%) tested individuals. Our data suggest that viral hepatitis, especially HEV, remains an under-recognized and significant public health problem in rural Bangladeshi populations, warranting further attention.

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Section: Discussionmentioning

confidence: 81%

Population Seroprevalence of Hepatitis E Virus Antibodies in Rural Bangladesh

Labrique¹,

Zaman²,

Hossain³

et al. 2009

The American Journal of Tropical Medicine and Hygiene

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“…Researchers found. All the clones of HEV isolated from Bangladesh had high homology with South Asian, Southeast Asian and Chinese clones of genotype 1, which is virulent to cause the maternal mortality 18 . In addition, malnutrition, folate deficiency and unhygienic habits of pregnant women may predispose to have high mortality rate in developing country like Bangladesh (19) .…”

Section: Discussionmentioning

confidence: 99%

Feto-Maternal Outcomes of Hepatitis E Virus Infection in Pregnancy of Bangladeshi women.

Sultana

Rozhana

Tabassum

et al. 2017

Bangladesh J Med Microbiol

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Hepatitis E virus (HEV) infection is responsible for more than half of acute viral hepatitis (AHV) with high feto-maternal complications. Bangladesh has high prevalence of HEV infection among pregnant women. This study was undertaken to observe fetal -maternal outcome of HEV infection in Bangladeshi pregnant women . For this purpose a total of 56 pregnant women with AVH were enrolled from two tertiary care hospitals of Dhaka, Bangladesh. Blood samples were collected and tested for HEV Ig-M, HBsAg and Anti HCV.Thirty one pregnant women were tested positive for HEV Ig-M, acted as case and rest 25 women had viral hepatitis other than HEV, acted as control group (non-HEV). Among the HEV infected pregnant women, 38.7% of the patients (12/31) were aged between 21-25 years with mean age of 23.7 + SD 4.5 years. Twelve (39%) AVH-E patient died due to fulminant hepatic failure (FHF), hepatic encephalopathy (HFE) and multiorgan dysfunction. Maternal mortality due to HEV was greater [ (RR), 9.6; 95% CI, 1.3 to 69.5] in HEV-infected women than in non-HEV infected women and it was higher in 2nd trimester (55.5%) then the 1st and 3rd trimester of pregnancy. Babies born to pregnant women with acute Hepatitis due to HEV (AHV-E) were more likely to have intrauterine death (RR 18.68; p = 0.03) and preterm delivery (RR 7.25; p = 0.05) than the non-HEV infected pregnant women. Only 23% (7/31) babies reached up to term maturity. In conclusion, his study reveals that comparing with non-HEV infection, pregnant women with AHV-E infection causes worse feto-maternal outcomes especially in the second trimester of pregnancy which needs special attention of healthcare providers to reduce bad obstetric outcome in HEV endemic countries.

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“…water-borne outbreaks (Corwin et al, 1996;Naik et al, 1992). Genotype 1 is mainly found in Asia and Africa (Sugitani et al, 2009;Teshale et al, 2010), while genotype 2 has been isolated from Mexico and Africa, but seems less common (Maila et al, 2004;Velázquez et al, 1990) (see Fig. 4).…”

Section: Genetic Diversitymentioning

confidence: 99%

Antiviral strategies for hepatitis E virus

Debing

Neyts

2014

Antiviral Research

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The hepatitis E virus is a common cause of acute hepatitis. Contrary to hepatitis B and C, hepatitis E is mostly a mild infection, although it has a high mortality in pregnant women and can evolve to chronicity in immunocompromised patients. Ribavirin and pegylated interferon-α are the only available therapies, but both have side effects that are not acceptable for prophylaxis or treatment of mild infections. In addition, these drugs cannot be used for all patient types (e.g. in case of pregnancy, specific organ transplants or co-morbidities) and in resource-poor settings. Hence there is an urgent need for better antiviral treatments that are efficacious and safe, also during pregnancy. In this review, a concise introduction to the virus and disease is provided, followed by a discussion of the available assay systems and potential molecular targets (viral proteins and host factors) for the development of inhibitors of HEV replication. Finally, directions for future research are presented.

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Detection of hepatitis E virus RNA and genotype in Bangladesh

Cited by 11 publications

References 25 publications

Population Seroprevalence of Hepatitis E Virus Antibodies in Rural Bangladesh

Population Seroprevalence of Hepatitis E Virus Antibodies in Rural Bangladesh

Feto-Maternal Outcomes of Hepatitis E Virus Infection in Pregnancy of Bangladeshi women.

Antiviral strategies for hepatitis E virus

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