Detection of Functional Homotopy in Traumatic Axonal Injury

Li, Jian; Gao, Lei; Xie, Kai; Zhan, Jie; Luo, Xiaoping; Wang, Hong; Zhang, Huifang; Zhao, Jing; Zhou, Fuqing; Zeng, Xiaoyang; He, Laichang; He, Yulin; Gong, Honghan

doi:10.1007/s00330-016-4302-x

Cited by 29 publications

(31 citation statements)

References 66 publications

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“…Additional conventional T2weighted (TR/TE = 4000/113 ms, slice thickness = 5 mm, matrix = 320 £ 256), T2-FLAIR images (TR/TE/TI = 8000/ 79/2722 ms, slice thickness = 5 mm, matrix = 320 £ 256) and SWI (TR/TE = 28/20 ms, flip angle = 15°, slice thickness = 1.2mm, matrix = 320 £ 256) and DWI (TR/ TE = 3100/91 ms, b = 1000 s/mm 2 , matrix =192£ 192) sequences of the brain were acquired for the diagnosis of DAI. Part of these typical lesions in DAI patients were reported in our previous work (11).…”

Section: Mri Data Acquisition and Clinical Assessmentsupporting

confidence: 53%

“…In recent years, increasing numbers of studies have revealed compensatory activation (7) or engagement (8) in working memory performance task, disrupted regional (9) and long-distance connectivity (10,11), and even network dysconnectivity (12). However, these studies relied on the assumption of the 'static' temporal strength or inter-region relationship in temporal pattern, neglecting to investigate the dynamic brain alterations or time-varying of the blood oxygen level dependent (BOLD) signal in resting-state scanning (13).…”

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confidence: 99%

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Characterizing Static and Dynamic Fractional Amplitude of Low-Frequency Fluctuation and its Prediction of Clinical Dysfunction in Patients with Diffuse Axonal Injury

Zhou

Zhan

Gong³

et al. 2021

Academic Radiology

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Rationale and Objectives: Recently, advanced magnetic resonance imaging has been widely adopted to investigate altered structure and functional activities in patients with diffuse axonal injury (DAI), this patient presumed to be caused by shearing forces and results in significant neurological effects. However, little is known regarding cerebral temporal dynamics and its predictive ability in the clinical dysfunction of DAI. Materials and Methods: In this study, static and dynamic fractional amplitude of low-frequency fluctuation (fALFF), an improved approach to detect the intensity of intrinsic neural activities, and their temporal variability were applied to examine the alteration between DAI patients (n = 24) and healthy controls (n = 26) at the voxel level. Then, the altered functional index was used to explore the clinical relationship and predict dysfunction in DAI patients. Results: We discovered that, compared to healthy controls, DAI patients showed commonly altered regions of static fALFF, and its variability was mainly located in the left cerebellum posterior lobe. Furthermore, decreased static fALFF values over the left cerebellum posterior lobe and bilateral medial frontal gyrus showed significant correlations with disease duration and Mini-Mental State Examination scores. More important, the increased temporal variability of dynamic fALFF in the left caudate could predict the severity of the Glasgow Coma Scale score in DAI patients. Conclusion: Overall, these results suggested selective abnormalities in intrinsic neural activities with reduced intensity and increased variability, and this novel predictive marker may be developed as a useful indicator for future connectomics or artificial intelligence analyses.

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Section: Mri Data Acquisition and Clinical Assessmentsupporting

confidence: 53%

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confidence: 99%

Characterizing Static and Dynamic Fractional Amplitude of Low-Frequency Fluctuation and its Prediction of Clinical Dysfunction in Patients with Diffuse Axonal Injury

Zhou

Zhan

Gong³

et al. 2021

Academic Radiology

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“…This approach differs from analyses of the regional activity intensity (amplitude of low-frequency fluctuations12), regional connectivity,13,14 and global connectivity,15 because the VMHC index emphasizes the idea that specific patterns of interhemispheric disconnection can reflect functional consequences for interhemispheric communication or coordination associated with pathological (disease) and physiological conditions 16–18. In several studies, abnormal homotopic connectivity in subjects with pathological states has been reported in patients with traumatic axonal injury,17 schizophrenia,19 autism,20 and cocaine addiction 21…”

Section: Introductionmentioning

confidence: 99%

Altered homotopic connectivity in postherpetic neuralgia: a resting state fMRI study

Jiang¹,

Bao

et al. 2016

JPR

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ObjectiveThe aim of this study was to explore interhemispheric intrinsic connectivity in patients with postherpetic neuralgia (PHN).MethodsWe obtained resting-state functional magnetic resonance imaging data from 18 right-handed PHN patients (11 males, 7 females; mean age, 59.67±8.41 years) and 18 well-matched healthy controls (11 males, 7 females; mean age, 38.50±7.51 years). Interhemispheric connectivity was examined using voxel-mirrored homotopic connectivity (VMHC), and seed-based functional connectivity analysis was performed.ResultsCompared with the healthy controls, the patients with PHN showed abnormally decreased homotopic connectivity in the dorsolateral prefrontal cortex and the precuneus and posterior cingulate cortex (PCUN/PCC). The decreased VMHC in the PCUN/PCC was positively correlated with the visual analog scale of PHN in the PHN patient group (ρ=0.651; P=0.006). Receiver operating characteristic (ROC) analysis revealed that the areas under the curves for the two brain regions were 0.898 for the prefrontal cortex and 0.923 for the PCUN/PCC, which indicated that the VMHC could be used to discriminate PHN patients from healthy controls. A subsequent seed-based functional connectivity analysis revealed widely disrupted intrinsic connectivity between the regions that showed local homotopic connectivity deficits and the areas subserving the default-mode network.ConclusionOur results indicated reduced interhemispheric functional connectivity in patients with PHN, which seems to be an important new avenue to investigate to better understand the nature of disconnection of the functional architecture in patients with PHN.

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“…Eighteen DAI patients were recruited from the Emergency and Trauma Center at the First Affiliated Hospital, Nanchang University. The following DAI criteria were used as in our previous study in which the homotopic functional connectivity results were reported 10 . The following inclusion criteria were applied: (a) the patient had a closed-head TBI (involving acceleration-deceleration or high-velocity rotational forces); (b) the patient was hemodynamically stable (to ensure that transfer to the scanner was clinically safe); (c) the patient was 16–60 years of age; (d) the patient’s Glasgow coma scale (GCS) score within 24 h after trauma was more than 8 (mild-to-moderate traumatic DAI); and (e) the patient undergoes MRI scanning within 6 months after trauma occurring 1 , 15 .…”

Section: Participants and Methodsmentioning

confidence: 99%

“…Resting-state functional MRI (rfMRI) has also provided considerable information on disrupted functional homotopy 10 , long-distance connectivity 11 , and networks 12 after traumatic brain injury. Recently, a summary systemically reviewed the association between local morphometry and local intrinsic activity measures 13 .…”

Section: Introductionmentioning

confidence: 99%

Thalamic atrophy and dysfunction in patients with mild-to-moderate traumatic diffuse axonal injury

Wu¹,

Zhou²,

Zhang

et al. 2018

NeuroReport

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Disrupted white matter structure has been established in patients with diffuse axonal injury (DAI), but morphological changes in gray matter and local intrinsic activity in the short and midterm (before 6 months) have not been documented in DAI patients. We hypothesized that regionally selective atrophy observed in deep gray matter in the short-term and mid-term periods in patients with mild-to-moderate DAI, local atrophy, and/or dysfunction would be related to clinical characteristics. We evaluated the changes in regional density and synchronization in 18 DAI patients separately using Diffeomorphic Anatomical Registration through Exponentiated Lie algebra-enhanced voxel-based morphometry and regional homogeneity (ReHo). Compared with the controls, DAI patients showed a decreased density in the bilateral thalami and decreased ReHo values in the ventral anterior and ventral lateral nuclei of the bilateral thalami. Pearson’s correlation analysis showed that decreased density in the bilateral thalami was correlated negatively with time since injury and decreased ReHo values in the ventral anterior and ventral lateral nuclei of the bilateral thalami were associated with a worsened motor assessment scale. These findings suggest that mild-to-moderate traumatic DAI within the short and midterm could lead to thalamic atrophy and that dysfunction in the bilateral thalami is associated with declining motor function. This study could potentially provide complementary evidence as an important element in longitudinal studies.

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Detection of Functional Homotopy in Traumatic Axonal Injury

Abstract: • Traumatic axonal injury is associated with decreased interhemispheric connectivity • Traumatic axonal injury couples with widely disrupted functional connectivity • These alterations support the default, salience, integrative, and executive functions.

Cited by 29 publications

References 66 publications

Characterizing Static and Dynamic Fractional Amplitude of Low-Frequency Fluctuation and its Prediction of Clinical Dysfunction in Patients with Diffuse Axonal Injury

Characterizing Static and Dynamic Fractional Amplitude of Low-Frequency Fluctuation and its Prediction of Clinical Dysfunction in Patients with Diffuse Axonal Injury

Altered homotopic connectivity in postherpetic neuralgia: a resting state fMRI study

Thalamic atrophy and dysfunction in patients with mild-to-moderate traumatic diffuse axonal injury

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