Characterizing Static and Dynamic Fractional Amplitude of Low-Frequency Fluctuation and its Prediction of Clinical Dysfunction in Patients with Diffuse Axonal Injury

Abstract

Rationale and Objectives: Recently, advanced magnetic resonance imaging has been widely adopted to investigate altered structure and functional activities in patients with diffuse axonal injury (DAI), this patient presumed to be caused by shearing forces and results in significant neurological effects. However, little is known regarding cerebral temporal dynamics and its predictive ability in the clinical dysfunction of DAI. Materials and Methods: In this study, static and dynamic fractional amplitude of low-frequency fluctuation (fALFF), an improved approach to detect the intensity of intrinsic neural activities, and their temporal variability were applied to examine the alteration between DAI patients (n = 24) and healthy controls (n = 26) at the voxel level. Then, the altered functional index was used to explore the clinical relationship and predict dysfunction in DAI patients. Results: We discovered that, compared to healthy controls, DAI patients showed commonly altered regions of static fALFF, and its variability was mainly located in the left cerebellum posterior lobe. Furthermore, decreased static fALFF values over the left cerebellum posterior lobe and bilateral medial frontal gyrus showed significant correlations with disease duration and Mini-Mental State Examination scores. More important, the increased temporal variability of dynamic fALFF in the left caudate could predict the severity of the Glasgow Coma Scale score in DAI patients. Conclusion: Overall, these results suggested selective abnormalities in intrinsic neural activities with reduced intensity and increased variability, and this novel predictive marker may be developed as a useful indicator for future connectomics or artificial intelligence analyses.

Disrupted topological organization of functional brain networks in traumatic axonal injury

“…Previous studies reported cerebellar atrophy in patients with TBI (Drijkoningen et al, 2015;Spanos et al, 2007) and lower activation within the cerebellum (Yang et al, 2012). Our previous work also showed that patients with TAI exhibited signi cantly reduced static fractional amplitude of lowfrequency uctuations (fALFF) in the left posterior lobe of the cerebellum (Zhou et al, 2021) and reduced interhemispheric coordination between the cerebellum posterior lobes (Li et al, 2017). Furthermore, analysis of the relationships between graph metrics and clinical measures showed that the nodal clustering coe cient of the right cerebellar hemisphere (VII) was negatively correlated with the MMSE score, suggesting a correlation with cognitive disorders in patients with TAI.…”

Temporal dynamic changes of intrinsic brain activity in Alzheimer’s disease and mild cognitive impairment patients: a resting-state functional magnetic resonance imaging study

“…However, not all compensatory activities are meaningful. Increased temporal variability may also indicate the temporal abnormity and instability in the resting state (60), causing a decline in the ability of the associated brain regions to participate in the normal cognitive loop. As the brain adapts, the compensation decreases later.…”

Abnormal fractional amplitude of low-frequency fluctuations in MOG-lgG optic neuritis patients: a resting-state functional MRI study

“…Lai CH, et al [28] 2015 Pure major depressive disorder Wang JJ, et al [29] 2016 Migraine Fang JW, et al [30] 2020 monocular blindness Shu Y, et al [31] 2020 Young depressed patients Zhou F, et al [32] 2020 diffuse axonal injury ance of fALFF in the near future. We found that fALFF value in bilateral inferior temporal lobes, right rectus, and left superior and right middle frontal lobes were increased in MOG-lgG ON patients compared to HCs, indicating that visual information processing was affected.…”

“…In other dieases, fALFF method was also used to have further results (Table 5, Ref. [28][29][30][31][32]). We use the method of fALFF to study the brain activity of patients with MOG-lgG ON Change, so as to achieve early detection of related complications and sequelae brain area abnormal fALFF signal prompts, to achieve timely detection and treatment, which is essential to improve quality of patients' daily life.…”