Detection of Epstein–Barr virus in different sources of materials from patients with oral lichen planus: a case–control study

Vieira, Rúbia da Rocha; Ferreira, Lígia; Biasoli, Éder Ricardo; Bernabé, Daniel Galera; Nunes, Cáris Maroni; Miyahara, Glauco Issamu

doi:10.1136/jclinpath-2015-203325

Cited by 10 publications

(15 citation statements)

References 33 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several groups have investigated the potential association of OLP with Epstein–Barr virus but have found no association . Recently, distinct expression profiles of human cytomegalovirus‐encoded microRNAs in the plasma of patients with OLP have been reported without known roles of these microRNAs in the etiology of OLP …”

Section: Association With Viral Infectionmentioning

confidence: 99%

The microbiology of oral lichen planus: Is microbial infection the cause of oral lichen planus?

Baek

Choi

2017

Molecular Oral Microbiology

View full text Add to dashboard Cite

SummaryOral lichen planus (OLP) is a variant of lichen planus (LP), a common chronic mucocutaneous inflammatory disease. Cutaneous lesions of LP are self-limiting, but OLP lesions are non-remissive, alternating periods of exacerbation and quiescence, and only symptomatic treatments exist for OLP. The precise etiology and pathogenesis of OLP are hardly understood, which is a major obstacle to the development of new therapeutics for this disease. OLP is considered a T-cell-mediated inflammatory disease.Although various antigens have been considered, what actually triggers the inflammatory response of T cells is unknown. Suggested predisposing factors include genetic factors, stress, trauma, and infection. The aim of this review was to determine whether microbial infection can cause OLP. We first reviewed the association between OLP and microbial factors, including viral, fungal, and bacterial infections. In addition, each microbial factor associated with OLP was assessed by modified guidelines of Fredricks and Relman to determine whether it establishes a causal relationship. In conclusion, no microbial factor yet fulfills the guidelines to establish the causality of OLP. By focusing on the unclarified issues, however, the potential roles of microbial factors in the pathogenesis of OLP will be soon elucidated. K E Y W O R D Sbacteria, causality, fungi, oral lichen planus, viruses | INTRODUCTIONLichen planus (LP), first described by Erasmus Wilson in 1869, is a common chronic mucocutaneous inflammatory disease affecting the skin, nails, eyes, urogenital tract, and oral mucosa.1 The prevalence of LP in the general population is 0.22%-5%. Although OLP is sometimes regarded as an autoimmune disorder, it is not classified as an autoimmune disease because no autoantigens have been identified. Suggested predisposing factors include genetic factors, stress, trauma, and infection. 5,6 In this article, microbial factors

show abstract

Section: Association With Viral Infectionmentioning

confidence: 99%

The microbiology of oral lichen planus: Is microbial infection the cause of oral lichen planus?

Baek

Choi

2017

Molecular Oral Microbiology

View full text Add to dashboard Cite

show abstract

“…In line with that, Sand et al 16 and Shariati et al 20 found significantly higher prevalence of EBV in OLP patients compared to healthy controls 16,20 . Contrarily, studies by Veira et al 21 and Sahebjamee et al 22 did not find a significant association between EBV and OLP 21,22 . Furthermore, a more recent study investigating the presence of EBV in OLP patients using the in situ hybridization technique (ISH) did not detect EBV neither in OLP cases nor in controls 23 .…”

Section: Introductionmentioning

confidence: 75%

“…The general characteristics of the included studies are summarized in Table 1. Ten case‐control studies 13‐16,20‐23,28,29 comprising 690 subjects (386 OLP cases and 304 healthy controls) were included in the present review; of these, 8 studies were eligible for the meta‐analysis 13‐16,20,21,28,29 . The studies were published between 1996 and 2018.…”

Section: Resultsmentioning

confidence: 99%

“…EBV has been associated with several benign and malignant head and neck disorders, including infectious mononucleosis, hairy leukoplakia, Sjogren’s syndrome, Burkitt’s lymphoma, Hodgkin’s Lymphoma, and nasopharyngeal carcinoma 17‐19 . Recently, several observational studies have investigated the possible role of EBV in pathogenesis of OLP, and conflicting results were reported 5,13‐15,20,21 . The early work by Pedersen 13 showed an aberration in the humoral immune response to EBV in OLP patients; the authors concluded that EBV might have a role in OLP pathogenesis 13 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The association between Epstein‐Barr virus and oral lichen planus: A systematic review and meta‐analysis

Ashraf

Al‐Maweri

Alaizari

et al. 2020

J Oral Pathology Medicine

View full text Add to dashboard Cite

Background Oral lichen planus (OLP) is a relatively common inflammatory disease, with unclear etiology. A number of studies have linked Epstein‐Barr virus (EBV) with OLP. The present systematic review and meta‐analysis aimed to evaluate the available evidence regarding the potential association between EBV and OLP. Methods Online databases (PubMed, Scopus, Web of Science, ProQuest, and Google Scholar) were searched from date of inception till May 2020. Studies were included if they met the following criteria: 1) observational studies that assessed the relationship between EBV and OLP, 2) the study comprised OLP patients and control subjects, 3) diagnosis of OLP was confirmed histopathologically, and 4) articles were in English. Studies without control groups, experimental studies, case reports, and reviews were excluded. The fixed‐effects model was performed for meta‐analyses using RevMan 5.3 software. Results A total of 10 studies comprising 386 OLP cases and 304 controls were included. Of these, only 8 studies were eligible for the meta‐analysis. The results of the quality assessment showed that only 2 studies were of high quality, while the remaining studies were of moderate quality. The results of the pooled eight studies revealed a significant positive association between EBV and OLP (OR = 4.41, 95% CI: [2.74, 7.11], P < .0001). Conclusion The results of the present systematic review suggest that EBV infection is statistically associated with increased risk of OLP. However, these results are preliminary, and high‐quality, large‐scale studies are warranted to further explore the potential role of EBV in the pathogenesis of OLP.

show abstract

“…By using PCR or ELISA some investigators detect antibodies against EBV in approximately 25% of LP patients ( 21 - 23 ) while others have found as high as 62% EBV positive tissue, 18% in saliva, 17% in exfoliated cells and 8% of plasma , using nested PCR ( 24 ). Still, no correlation between OLP and EBV was seen.…”

Section: Discussionmentioning

confidence: 99%

Epstein-Barr virus is not detected in mucosal lichen planus

Danielsson

Nylander²,

Sjöström³

et al. 2018

Med Oral

View full text Add to dashboard Cite

BackgroundLichen planus (LP) is a chronic inflammatory, immunological, mucocutaneous disease can affect skin, genital and oral mucosa. Oral lichen planus (OLP) is the most common noninfectious, chronic inflammatory oral disease affecting 1-2% of the general adult population. World Health Organization (WHO) classifies OLP as a potentially malignant disorder. Epstein Barr virus or human herpesvirus-4, is a member of the herpes virus family and one of the most ubiquitous viruses known to human, infecting approximately 90% of the world’s adult population. The virus often infects B lymphocytes resulting in a wide spectrum of mucocutaneous and systemic diseases, ranging from mild lesions to aggressive malignancies. The aim of this study was to investigate expression of the EBV encoded RNAs EBER1 and EBER2 in oral and genital lichen planus and compare results with normal tissues in situ hybridization which is considered the golden standard for detection of EBER.Material and MethodsA total of 68 biopsies, 25 oral LP, 26 genital LP, 10 oral controls and finally 7 genital controls were analysed using situ hybridization.ResultsAll samples had RNA as shown by the control slide, whereas no case contained neither EBER1 nor EBER2.ConclusionsBased on results from our study EBV is not involved in aetiology of lichen planus. Key words:Mucosal lichen planus, Epstein - Barr virus.

show abstract

Detection of Epstein–Barr virus in different sources of materials from patients with oral lichen planus: a case–control study

Abstract: No relationship between EBV and OLP was found. However, all sources tested in this study were considered suitable for the detection of viruses.

Cited by 10 publications

References 33 publications

The microbiology of oral lichen planus: Is microbial infection the cause of oral lichen planus?

The microbiology of oral lichen planus: Is microbial infection the cause of oral lichen planus?

The association between Epstein‐Barr virus and oral lichen planus: A systematic review and meta‐analysis

Epstein-Barr virus is not detected in mucosal lichen planus

Contact Info

Product

Resources

About