Detection of endogenous hydrogen peroxide in living cells with para-nitrophenyl oxoacetyl rhodamine as turn-on mitochondria-targeted fluorescent probe

Gu, Tianchu; Mo, Shanyan; Mu, Yingqi; Huang, Xin; Hu, Liming

doi:10.1016/j.snb.2020.127731

Cited by 41 publications

(14 citation statements)

References 53 publications

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“…Hu’s group reported a probe (example 5) based on rhodamine derivatives as fluorophores. 7 With 4-nitro-α-ketoamide as the recognition group, the probe underwent a process of donor excitation light-induced electron transfer. After adding H 2 O 2 , the recognition group was cleaved to release a new fluorophore, which had a significant fluorescence at 730 nm ( Figure 7 ).…”

Section: Types Of H 2 O 2 Detec...mentioning

confidence: 99%

Recent Progress in Organic Small-Molecule Fluorescent Probe Detection of Hydrogen Peroxide

Xiao

Chen

et al. 2022

ACS Omega

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The fluorescent probe has become an important method for accurate detection of H 2 O 2 , with advantages of simple operation, high sensitivity, good selectivity, and real-time dynamic monitoring. This paper reviews the research progress in organic small-molecule fluorescent probe H 2 O 2 detection methods that are based on different recognition reactions. In addition, the application prospect of fluorescent probes in the detection of trace H 2 O 2 is anticipated.

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Section: Types Of H 2 O 2 Detec...mentioning

confidence: 99%

Recent Progress in Organic Small-Molecule Fluorescent Probe Detection of Hydrogen Peroxide

Xiao

Chen

et al. 2022

ACS Omega

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“…Compound 2 was synthesized according to the method previously reported by our group [39]. Under ice bath conditions, 3 g of raw material 2-(4-diethylamino-2hydro-xybenzoyl) benzoic acid (9.6 mmol) and 1.98 mL 3).…”

Section: Synthesis and Characterization 321 Synthesis Of Compoundmentioning

confidence: 99%

A rhodamine derivative probe for highly selective detection of Cu(II)

Hu¹,

Lin²,

Wang³

et al. 2022

Front. Biosci. (Landmark Ed)

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Background: Abnormal Cu(II) ions levels may affect many biological functions, and it is of great importance to detect Cu(II) ions in organisms. Methods: Herein, we report a near-infrared (NIR) fluorescent probe EtRh-N-NH2 for the detection of Cu(II). In the probe structure, a rhodamine core was used, and a hydrazine group was employed as the responsive site. Results & Conlusions: EtRh-N-NH2 displayed sensitive, specific and fast response upon Cu(II) with excellent linear relationship between the concentration and fluorescence emission intensity in 0-1 µM range. The releasing EtRh-COOH exhibited 762 nm of emission wavelength with a 75 nm of Stokes shift.

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“…Cholesterol can be decomposed under the catalysis of cholesterol oxidase (ChOx) to produce H 2 O 2 , as shown in eq 1. Therefore, cholesterol levels can be determined by evaluating the content of H 2 O 2 . With the progress of science and technology, H 2 O 2 detection methods have been constantly upgraded, from fluorescence and colorimetric methods to the electrochemical method. − However, among them, the colorimetric method has the advantages of low cost, strong practicability, high efficiency, and simplicity in practical applications. Horseradish peroxidase (HRP), a kind of natural peroxidase, is known as a precise biocatalyst for H 2 O 2 colorimetric sensors.…”

Section: Introductionmentioning

confidence: 99%

Porphyrin-Modified NiS₂ Nanoparticles Anchored on Graphene for the Specific Determination of Cholesterol

Zhu

Xue

et al. 2021

ACS Appl. Nano Mater.

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Exploring peroxidase-like nanozymes with high catalytic activity is an urgent task to construct a fast, convenient, and selective colorimetric sensing platform. In this work, a nanozyme, 5,10,15,20-tetrakis(4-carboxyl phenyl)porphyrin-functionalized NiS 2 nanoparticles, anchored on the surface of graphene (Por-NiS 2 /GO) was designed. Compared with NiS 2 nanoparticles anchored on the surface of graphene (NiS 2 /GO), Por-NiS 2 /GO had a higher peroxidase-like activity due to the introduction of porphyrin. The size of NiS 2 nanoparticles was about 110−250 nm. The peroxidase-like behaviors of Por-NiS 2 /GO were evaluated using the chromogenic substrate 3,3′,5,5′-tetramethylbenzidine (TMB) with a fast-blue color change in less than 1 min. Electron spin resonance (ESR) data revealed that the excellent performance of Por-NiS 2 / GO was due to the active oxygen species produced, including hydroxyl radical ( • OH) and superoxide radical ( • O 2 − ), during the catalytic reaction, owing to the synergetic effect among different components including porphyrin, NiS 2 , and GO. Thus, based on the enhanced peroxidase-like activity of Por-NiS 2 /GO, a fast, sensitive, and selective colorimetric sensing platform of H 2 O 2 has been constructed, and furthermore, a sensing platform for cholesterol was also developed coupled with cholesterol oxidase (ChOx). The colorimetric sensing platform was validated by detecting cholesterol in serum samples.

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Detection of endogenous hydrogen peroxide in living cells with para-nitrophenyl oxoacetyl rhodamine as turn-on mitochondria-targeted fluorescent probe

Cited by 41 publications

References 53 publications

Recent Progress in Organic Small-Molecule Fluorescent Probe Detection of Hydrogen Peroxide

Recent Progress in Organic Small-Molecule Fluorescent Probe Detection of Hydrogen Peroxide

A rhodamine derivative probe for highly selective detection of Cu(II)

Porphyrin-Modified NiS₂ Nanoparticles Anchored on Graphene for the Specific Determination of Cholesterol

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Detection of endogenous hydrogen peroxide in living cells with para-nitrophenyl oxoacetyl rhodamine as turn-on mitochondria-targeted fluorescent probe

Cited by 41 publications

References 53 publications

Recent Progress in Organic Small-Molecule Fluorescent Probe Detection of Hydrogen Peroxide

Recent Progress in Organic Small-Molecule Fluorescent Probe Detection of Hydrogen Peroxide

A rhodamine derivative probe for highly selective detection of Cu(II)

Porphyrin-Modified NiS2 Nanoparticles Anchored on Graphene for the Specific Determination of Cholesterol

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Product

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Porphyrin-Modified NiS₂ Nanoparticles Anchored on Graphene for the Specific Determination of Cholesterol