Detection of early primary colorectal cancer with upconversion luminescent NP-based molecular probes

Liu, Chunyan; Qi, Yifei; Qiao, Ruirui; Hou, Yi; Chan, Ka-Ying; Li, Ziqian; Huang, Jiayi; Jing, Lihong; Du, Jie; Gao, Mingyuan

doi:10.1039/c5nr07858j

Cited by 35 publications

(15 citation statements)

References 30 publications

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“…This challenge was recently overcome through modification of folic acid via covalent coupling with two Jeffamine polyetheramines. This resulting modified folic acid is highly water soluble and favors a coupling reaction with nanoparticles in the aqueous phase through the remaining amino group on Jeffamine …”

Section: Semiconductor Quantum Dotsmentioning

confidence: 99%

Biocompatible Semiconductor Quantum Dots as Cancer Imaging Agents

et al. 2018

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Approximately 1.7 million new cases of cancer will be diagnosed this year in the United States leading to 600 000 deaths. Patient survival rates are highly correlated with the stage of cancer diagnosis, with localized and regional remission rates that are much higher than for metastatic cancer. The current standard of care for many solid tumors includes imaging and biopsy with histological assessment. In many cases, after tomographical imaging modalities have identified abnormal morphology consistent with cancer, surgery is performed to remove the primary tumor and evaluate the surrounding lymph nodes. Accurate identification of tumor margins and staging are critical for selecting optimal treatments to minimize recurrence. Visible, fluorescent, and radiolabeled small molecules have been used as contrast agents to improve detection during real-time intraoperative imaging. Unfortunately, current dyes lack the tissue specificity, stability, and signal penetration needed for optimal performance. Quantum dots (QDs) represent an exciting class of fluorescent probes for optical imaging with tunable optical properties, high stability, and the ability to target tumors or lymph nodes based on surface functionalization. Here, state-of-the-art biocompatible QDs are compared with current Food and Drug Administration approved fluorophores used in cancer imaging and a perspective on the pathway to clinical translation is provided.

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Section: Semiconductor Quantum Dotsmentioning

confidence: 99%

Biocompatible Semiconductor Quantum Dots as Cancer Imaging Agents

et al. 2018

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“…On the other hand, the cellular uptake of these dual conjugated VLNPs by the normal cells (3T3 and CCD-112) was much lower compared with the cancer cells. This can be explained by the fact that the FR is highly expressed in HeLa and HT29 cancer cells [ 29 , 30 ], but it is lowly expressed in normal cells [ 28 , 31 ]. In addition, cancer cells overexpress the α-FR which has a high affinity to the free R-carboxylic acid of the conjugated FA molecules, whereas, normal cells mostly express the β-FR which has a higher binding affinity for 5-methyltetrahydrofolate, the reduced form of FA [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

A Dual Bioconjugated Virus-Like Nanoparticle as a Drug Delivery System and Comparison with a pH-Responsive Delivery System

Biabanikhankahdani

Alitheen

et al. 2018

Nanomaterials

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Modifications of virus-like nanoparticles (VLNPs) using chemical conjugation techniques have brought the field of virology closer to nanotechnology. The huge surface area to volume ratio of VLNPs permits multiple copies of a targeting ligand and drugs to be attached per nanoparticle. By exploring the chemistry of truncated hepatitis B core antigen (tHBcAg) VLNPs, doxorubicin (DOX) was coupled covalently to the external surface of these nanoparticles via carboxylate groups. About 1600 DOX molecules were conjugated on each tHBcAg VLNP. Then, folic acid (FA) was conjugated to lysine residues of tHBcAg VLNPs to target the nanoparticles to cancer cells over-expressing folic acid receptor (FR). The result demonstrated that the dual bioconjugated tHBcAg VLNPs increased the accumulation and uptake of DOX in the human cervical and colorectal cancer cell lines compared with free DOX, resulting in enhanced cytotoxicity of DOX towards these cells. The fabrication of these dual bioconjugated nanoparticles is simple, and drugs can be easily conjugated with a high coupling efficacy to the VLNPs without any limitation with respect to the cargo’s size or charge, as compared with the pH-responsive system based on tHBcAg VLNPs. These dual bioconjugated nanoparticles also have the potential to be modified for other combinatorial drug deliveries.

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“…triggers sole UCNP uptake in folate receptor overexpressing cancer cell lines in vitro and in vivo. [56][57][58][59][60][61] Besides folic acid, conjugation of nanophosphors to various targeting units has been reported. Antibodies, functionalisable glycoproteins, are known for their outstandingly high affinity binding to certain targets ranging from metabolites to receptors.…”

Section: Lanthanide Conjugates In Diagnostics and Therapymentioning

confidence: 99%