Lanthanide conjugates as versatile instruments for therapy and diagnostics

Abstract

Lanthanides have demonstrated outstanding properties in many fields of research including biology and medicinal chemistry.

Prospects for the Use of Metal-Based Nanoparticles as Adjuvants for Local Cancer Immunotherapy

“…These metals, also known as lanthanides, include elements with atomic numbers ranging from 57 to 71 (e.g., europium, gadolinium, cerium, and yttrium) [ 232 ]. Their unique luminescence and magnetic properties make them the metals of choice for the next generation theranostics that efficiently combine the two central pillars of medicine—diagnostics and therapy [ 233 ]. A recent review explores the possibility of using such materials for combined immuno- and photo-therapies, including photodynamic therapy (PDT) and photothermal therapy (PTT) [ 234 ].…”

Investigation of Ln3+ complexation by a DOTA derivative substituted by an imidazothiadiazole: synthesis, solution structure, luminescence and relaxation properties

“…2 In the last decades, coordination compounds formed with Ln 3+ have attracted much attention due to their successful biomedical applications, in both diagnosis and therapy. [3][4][5][6][7][8][9][10] For example, several Gd 3+ complexes have been clinically approved as magnetic resonance imaging (MRI) contrast agents. 3 Furthermore, several paramagnetic Ln 3+ complexes are luminescent and can be used for optical imaging or as probes in bioassays.…”