Detection of early changes in the post-radiosurgery vestibular schwannoma microenvironment using multinuclear MRI

Lewis, Daniel; McHugh, Damien J.; Li, Ka‐Loh; Zhu, Xiaoping; McBain, Catherine; Lloyd, Simon; Jackson, Alan; Pathmanaban, Omar; King, Andrew; Coope, David

doi:10.1038/s41598-021-95022-6

Cited by 8 publications

(16 citation statements)

References 55 publications

(84 reference statements)

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“…This potential clinical implication has not been addressed so far. Lewis et al [ 40 ] investigated the changes of the vestibular schwannoma microenvironment in patients who underwent stereotactic radiosurgery using multinuclear MRI. They suggested that patients who showed a well response to stereotactic radiosurgery and tumor growth attenuation following stereotactic radiosurgery had a reduced vascular supply of the vestibular schwannoma and a reduced amount of pro-tumoral TAM infiltrates in the tumor microenvironment.…”

Section: Discussionmentioning

confidence: 99%

Elevated baseline C-reactive protein levels predict poor progression-free survival in sporadic vestibular schwannoma

et al. 2021

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Background Recent investigations showed emerging evidence of the role of inflammation in the growth of sporadic vestibular schwannoma (VS). The present retrospective study investigated the impact of systemic inflammation on tumor progression using serum C-reactive protein (CRP) levels in a series of 87 surgically treated sporadic VS patients. Methods The optimal cut-off value for CRP was defined as 3.14 mg/dl according to the receiver operating characteristic curve (AUC: 0.70, 95% CI 0.47–0.92). Patient cohort was dichotomized into normal (n = 66; < 3.14 mg/dl) and high baseline (n = 21; ≥ 3.14 mg/dl) CRP groups. Results No significant differences in age, sex, comorbidities influencing the systemic inflammatory state, Karnofsky performance status (KPS), tumor size, extent of resection, or MIB-1 index were identified between the two groups defined by the baseline CRP levels. Univariable analysis demonstrated that a high CRP level (≥ 3.14 mg/dl) is significantly associated with a shortened progression-free survival (PFS) (hazard ratio (HR): 6.05, 95% CI 1.15–31.95, p = 0.03). Multivariable Cox regression analysis considering age, extent of resection, KPS, tumor size, and baseline CRP confirmed that an elevated CRP level (≥ 3.14 mg/dl) is an independent predictor of shortened PFS (HR: 7.20, 95% CI 1.08–48.14, p = 0.04). Conclusions The baseline CRP level thus serves as an independent predictor of PFS. Further investigations of the role of inflammation and tumor inflammatory microenvironment in the prediction of prognosis in sporadic VS are needed. Graphical abstract

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Section: Discussionmentioning

confidence: 99%

Elevated baseline C-reactive protein levels predict poor progression-free survival in sporadic vestibular schwannoma

et al. 2021

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“…A study was conducted on five patients using 1.5 Tesla 1 H and 23 Na MRI. Sodium bioscales highlighted early changes in VS and an increase in tumor TSC as measured by 23 Na MRI, detectable at 2 weeks after radiotherapy [ 40 ]. Other studies have used 1 H/ 23 Na MRI 7 Tesla to detect intracellular and extracellular components of TSC in breast cancer in vitro and in vivo studies on patients.…”

Section: The Physical Phenomenon Of Magnetic Resonancementioning

confidence: 99%

Multinuclear MRI in Drug Discovery

et al. 2022

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The continuous development of magnetic resonance imaging broadens the range of applications to newer areas. Using MRI, we can not only visualize, but also track pharmaceutical substances and labeled cells in both in vivo and in vitro tests. 1H is widely used in the MRI method, which is determined by its high content in the human body. The potential of the MRI method makes it an excellent tool for imaging the morphology of the examined objects, and also enables registration of changes at the level of metabolism. There are several reports in the scientific publications on the use of clinical MRI for in vitro tracking. The use of multinuclear MRI has great potential for scientific research and clinical studies. Tuning MRI scanners to the Larmor frequency of a given nucleus, allows imaging without tissue background. Heavy nuclei are components of both drugs and contrast agents and molecular complexes. The implementation of hyperpolarization techniques allows for better MRI sensitivity. The aim of this review is to present the use of multinuclear MRI for investigations in drug delivery.

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“…Its signal intensity is related to factors such as proton density, longitudinal (T 1 ) and transversal (T 2 ) relaxivity times and the cellular microenvironment and can be enhanced by the use of CAs. [131][132][133] Common Gd complexes, such as Magnevist, are widely used as CAs due to their long electron spin relaxation time but have disadvantages such as short cycle time in the body, low longitudinal relaxation (R 1 ) and single function. Using plant polyphenols as organic ligands to synthesize Gd/ Fe-bimetallic-phenolic coordination polymer NPs can effectively enhance the R 1 , and the molar ratio of R 1 to Gd/Fe is positively correlated.…”

Section: Medical Imagingmentioning

confidence: 99%