Applications of metal–phenolic networks in nanomedicine: a review

Abstract

In this paper, the assembly process and the material properties of MPNs are discussed, and the application scope and prospect of MPNs are clarified. This paper provides new ideas for the construction of nanoplatforms for therapeutics and diagnostics.

Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine

“…These structures are complex and diverse, and widely distributed in vegetables, fruits, spices, herbs, tea, and grapes among other sources. 126 The demonstrated benefits of these compounds include anti-inflammatory, anti-tumor, anti-vascular, antioxidant, and antibacterial bioactivities. 127 The distinct properties of these molecules, including antioxidant activity, anti-aging effects, substrate adsorption, adhesion, enzyme inhibition, and biocompatibility, appear to depend on the positions of various functional groups such as carbon–carbon double bonds, phenolic hydroxyl moieties, and carbonyl groups.…”

Recent Advances of Fe(III)/Fe(II)-MPNs in Biomedical Applications

“…Since the strong coordination interactions between phenolic compounds (e.g., GA, EGCG) of the corresponding MPN and iron ions contribute to the formation of different charge transfer bands and the appearance of new absorption in the near-infrared region, making MPNs good photothermal nano-agents [ 14 , 119 , 120 ] as well as drug-carrying tools, Fe-TA has an excellent photothermal conversion rate and is used in various therapeutic systems. However, since PT, as a therapy, requires high levels of photothermal agents and photosensitizers, efficient photothermal agents are needed to enhance the efficacy of PT.…”

Synergistic Therapeutic Effects of D-Mannitol–Cerium–Quercetin (Rutin) Coordination Polymer Nanoparticles on Acute Lung Injury

“…The ease of preparation, outstanding characteristics, and promising medical applications of MPNs have attracted considerable attention. By coordinating phenolic ligands and metal ions, MPNs demonstrate their potential as multifunctional theranostic nanoplatforms, possessing unique attributes like a rapid preparation process, minimal cytotoxicity, and pH responsiveness [ 24 , 25 ]. The use of metal–organic frameworks and the formation of metal chelates, such as those involving cerium ions, can effectively tackle these challenges [ 26 ].…”